Future of ToxicologyMetabolic Activation and Drug Design: Challenges and Opportunities in Chemical Toxicology

Can the pharmaceutical industry reduce attrition rates?

2004 • 3,946 citations

Idiosyncratic drug hepatotoxicity

2005 • 999 citations

Drug−Protein Adducts: An Industry Perspective on Minimizing the Potential for Drug Bioactivation in Drug Discovery and Development

2003 • 697 citations

Role of Metabolism in Drug-Induced Idiosyncratic Hepatotoxicity

2005 • 322 citations

Elucidating mechanisms of drug-induced toxicity

2005 • 303 citations

Subcellular binding and effects on calcium homeostasis produced by acetaminophen and a nonhepatotoxic regioisomer, 3′-hydroxyacetanilide, in mouse liver

1989 • 289 citations

Minimising the potential for metabolic activation in drug discovery

2005 • 219 citations

Cytosolic and Nuclear Protein Targets of Thiol-Reactive Electrophiles

2005 • 147 citations

Animal models of idiosyncratic drug reactions

2004 • 100 citations

In Vitro Bioactivation of Dihydrobenzoxathiin Selective Estrogen Receptor Modulators by Cytochrome P450 3A4 in Human Liver Microsomes: Formation of Reactive Iminium and Quinone Type Metabolites

2005 • 59 citations

Metabolic Activation of a Pyrazinone-Containing Thrombin Inhibitor. Evidence for Novel Biotransformation Involving Pyrazinone Ring Oxidation, Rearrangement, and Covalent Binding to Proteins

2003 • 43 citations

Covalent binding of acetaminophen to mouse hemoglobin. Identification of major and minor adducts formed in vivo and implications for the nature of the arylating metabolites

1988 • 43 citations

Bioactivation of 2,3-Diaminopyridine-Containing Bradykinin B₁ Receptor Antagonists: Irreversible Binding to Liver Microsomal Proteins and Formation of Glutathione Conjugates

2005 • 29 citations

Conversion of the 2,2,6,6-Tetramethylpiperidine Moiety to a 2,2-Dimethylpyrrolidine by Cytochrome P450: Evidence for a Mechanism Involving Nitroxide Radicals and Heme Iron

2004 • 25 citations