Pulmonary and anti-platelet effects of intravenous and inhaled prostacyclin in man

An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation

1976 • 3,613 citations

Arterial walls are protected against deposition of platelet thrombi by a substance (prostaglandin X) which they make from prostaglandin endoperoxides

1976 • 1,012 citations

A NEW METHOD FOR THE QUANTITATIVE DETECTION OF PLATELET AGGREGATES IN PATIENTS WITH ARTERIAL INSUFFICIENCY

1974 • 494 citations

Relationship of inhibition of prostaglandin biosynthesis by analgesics to asthma attacks in aspirin-sensitive patients.

1975 • 490 citations

Prostacyclin (PGX) is the endogeneous metabolite responsible for relaxation of coronary arteries induced by arachidonic acid

1977 • 412 citations

Prostacyclin is a circulating hormone

1978 • 380 citations

Generation of prostacyclin by lungs in vivo and its release into the arterial circulation

1978 • 374 citations

Clinical patterns of hypersensitivity to nonsteroidal anti-inflammatory drugs and their pathogenesis

1977 • 350 citations

The generation of prostacyclin by arteries and by the coronary vascular bed is reduced in experimental atherosclerosis in rabbits

1977 • 287 citations

COMPARISON OF THE VASODEPRESSOR EFFECTS OF PROSTACYCLIN AND 6‐OXO‐PROSTAGLANDIN F_1α WITH THOSE OF PROSTAGLANDIN E₂ IN RATS AND RABBITS

1978 • 277 citations

Sex and age differences in human platelet aggregation

1975 • 267 citations

Bronchial Hyperreactivity to Prostaglandin F2 and Histamine in Patients with Asthma

1973 • 217 citations

Release of novel prostaglandins and thromboxanes after immunological challenge of guinea pig lung

1976 • 192 citations

Circulatory and anti-platelet effects of intravenous prostacyclin in healthy men

1978 • 181 citations

Thromboxane Generation and Platelet Aggregation in Survivals of Myocardial Infarction

1978 • 125 citations

Aspirin-induced asthma

1976 • 112 citations

Effects of Inhaled Prostaglandins E1, E2 and F2α on the Airway Resistance of Healthy and Asthmatic Man

1975 • 106 citations

Aspects of Prostaglandin Function in the Lung

1977 • 92 citations

Aspects of Prostaglandin Function in the Lung

1977 • 79 citations

Effect of testosterone, sex and age on experimentally induced arterial thrombosis

1976 • 60 citations

Arachidonate-induced thrombosis in mice: effects of gender or testosterone and estradiol administration

1977 • 53 citations

Asthma relieved by aspirin and by other cyclo-oxygenase inhibitors.

1978 • 34 citations

Bronchial Reactivity to Prostaglandins F<sub>2α</sub>, E<sub>2</sub>, and Histamine in Different Types of Asthma

1977 • 26 citations