Differential effects of insulin resistance on leucine and glucose kinetics in obesity

Glucose clamp technique: a method for quantifying insulin secretion and resistance.

1979 • 7,240 citations

Classification and Diagnosis of Diabetes Mellitus and Other Categories of Glucose Intolerance

1979 • 4,730 citations

Relation of Body Fat Distribution to Metabolic Complications of Obesity*

1982 • 1,919 citations

INFLUENCES OF GLUCOSE LOADING AND OF INJECTED INSULIN ON HEPATIC GLUCOSE OUTPUT*

1959 • 1,674 citations

The determination of tryptophan in plasma, liver, and urine.

1967 • 826 citations

Plasma Amino Acid Levels and Insulin Secretion in Obesity

1969 • 772 citations

Effects of arterial versus venous sampling on analysis of glucose kinetics in man

1976 • 720 citations

Mechanisms of insulin resistance in human obesity: evidence for receptor and postreceptor defects.

1980 • 665 citations

Excessive Insulin Response to Glucose in Obese Subjects as Measured by Immunochemical Assay

1963 • 573 citations

Measurement of leucine metabolism in man from a primed, continuous infusion of L-[1-3C]leucine

1980 • 505 citations

Muscle Protein Synthesis Measured by Stable Isotope Techniques in Man: The Effects of Feeding and Fasting

1982 • 446 citations

Amino acid balance across tissues of the forearm in postabsorptive man. Effects of insulin at two dose levels

1969 • 438 citations

Amino acid metabolism in exercising man

1971 • 431 citations

Insulin-mediated reduction of whole body protein breakdown. Dose-response effects on leucine metabolism in postabsorptive men.

1985 • 365 citations

Effect of insulin and plasma amino acid concentrations on leucine metabolism in man. Role of substrate availability on estimates of whole body protein synthesis.

1987 • 349 citations

Splanchnic and peripheral glucose and amino acid metabolism in diabetes mellitus

1972 • 312 citations

Hyperinsulinemia, upper body adiposity, and cardiovascular risk factors in non-diabetics

1988 • 262 citations

Stimulation of amino acid transport by insulin in the isolated rat diaphragm

1958 • 262 citations

Use of reciprocal pool specific activities to model leucine metabolism in humans

1985 • 245 citations

Splanchnic glucose and amino acid metabolism in obesity.

1974 • 206 citations

Differential effects of hyperinsulinemia and hyperaminoacidemia on leucine-carbon metabolism in vivo. Evidence for distinct mechanisms in regulation of net amino acid deposition.

1987 • 197 citations

Effect of poor diabetic control and obesity on whole body protein metabolism in man

1983 • 194 citations

Substrate and Energy Metabolism in Man

1985 • 180 citations

Evidence that insulin resistance is responsible for the decreased thermic effect of glucose in human obesity.

1985 • 152 citations

Non-steady state: error analysis of Steele's model and developments for glucose kinetics

1987 • 150 citations

Metabolic effects of very low calorie weight reduction diets.

1984 • 135 citations

Analysis of (1-13C)leucine and (13C)KIC in plasma by capillary gas chromatography/mass spectrometry in protein turnover studies

1985 • 126 citations

Insulin dose-dependent reductions in plasma amino acids in man

1986 • 122 citations

Insulin secretion, insulin resistance, and obesity.

1982 • 117 citations

Serum tryptophan level after carbohydrate ingestion: Selective decline in non-albumin-bound tryptophan coincident with reduction in serum free fatty acids

1973 • 109 citations

Plasma amino acids and insulin levels in obesity: Response to carbohydrate intake and tryptophan supplements

1988 • 89 citations

Underestimation of hepatic glucose production by radioactive and stable tracers

1987 • 74 citations

Protein Degradation in Human Skeletal Muscle Tissue: The Effect of Insulin, Leucine, Amino Acids and Ions

1981 • 70 citations

Leucine Metabolism in Type II Diabetes Mellitus

1986 • 70 citations

Whole body protein turnover, studied with 15N-glycine, and muscle protein breakdown in mildly obese subjects during a protein-sparing diet and a brief total fast

1980 • 58 citations

Insulin-dependent metabolism of branched-chain amino acids in obesity

1984 • 56 citations

Glucose and amino acid metabolism in aging man: Differential effects of insulin

1988 • 53 citations

Hyperaminoacidaemia reduces insulin-mediated glucose disposal in healthy man

1985 • 53 citations

Evidence for diminished brain 5-hydroxytryptamine biosynthesis in obese diabetic and non-diabetic humans

1985 • 40 citations

Whole Body Protein Breakdown Rates and Hormonal Adaptation in Fasted Obese Subjects*

1983 • 38 citations

Leucine metabolism in type II diabetes mellitus

1986 • 35 citations

Influence of insulin on blood levels of branched chain keto and amino acids in man

1983 • 31 citations

Modulation of leucine oxidation and turnover by graded amounts of carbohydrate intake in obese subjects

1982 • 26 citations

Normal valine disposal in obese subjects with impaired glucose disposal: Evidence for selective insulin resistance

1981 • 24 citations

The treatment of obesity by carbohydrate deprivation suppresses plasma tryptophan and its ratio to other large neutral amino acids

1983 • 19 citations

Failure of carbohydrate to spare leucine oxidation in obese subjects.

1987 • 19 citations

Effects of physical training and lean body mass of plasma amino acids in man

1978 • 13 citations

Relation between obesity, insulinemia, and serum amino acid concentrations in a sample of Italian adults.

1982 • 13 citations

Relation between obesity, insulinemia, and serum amino acid concentrations in a sample of Italian adults.

1982 • 11 citations

Somatostatin infusion enhances hepatic glucose production during hyperglucagonemia

1988 • 6 citations