High Level Transcription of the Complement Regulatory Protein CD59 Requires an Enhancer Located in Intron 1

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Caspases: killer proteases

1997 • 2,440 citations

CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements

1987 • 1,792 citations

GPI-Anchored Cell-Surface Molecules Complexed to Protein Tyrosine Kinases

1991 • 848 citations

CD59, an LY-6-like protein expressed in human lymphoid cells, regulates the action of the complement membrane attack complex on homologous cells.

1989 • 640 citations

Human complement regulatory proteins protect swine-to-primate cardiac xenografts from humoral injury

1995 • 538 citations

Human protectin (CD59), an 18,000-20,000 MW complement lysis restricting factor, inhibits C5b-8 catalysed insertion of C9 into lipid bilayers.

1990 • 529 citations

The complement-inhibitory activity of CD59 resides in its capacity to block incorporation of C9 into membrane C5b-9.

1990 • 403 citations

The formation and function of DNase I hypersensitive sites in the process of gene activation.

1988 • 394 citations

In Vivo Transfer of GPI-Linked Complement Restriction Factors from Erythrocytes to the Endothelium

1995 • 254 citations

Status of the transcription factors database (TFD)

1993 • 125 citations

Apoptosis is associated with reduced expression of complement regulatory molecules, adhesion molecules and other receptors on polymorphonuclear leucocytes: functional relevance and role in inflammation.

1995 • 102 citations

Cross‐linking of CD59 and of other glycosyl phosphatidylinositol‐anchored molecules on neutrophils triggers cell activation via tyrosine kinase

1993 • 94 citations

[14] Analysis of hypersensitive sites in chromatin

1989 • 72 citations

Amplified gene expression in CD59-transfected Chinese hamster ovary cells confers protection against the membrane attack complex of human complement

1991 • 63 citations

Gene structure of human CD59 and demonstration that discrete mRNAs are generated by alternative polyadenylation

1992 • 51 citations

The CD59 antigen ‐ a multifunctional molecule

1992 • 39 citations

Transfection of human CD59 complementary DNA into rat cells confers resistance to human complement

1991 • 34 citations

Analysis of the gene that encodes the complement regulatory protein, membrane inhibitor of reactive lysis (CD59). Identification of an alternatively spliced exon and characterization of the transcriptional regulatory regions of the promoter.

1996 • 30 citations

Human CD59 expressed in transgenic mouse hearts inhibits the activation of complement

1995 • 26 citations