Blocking naloxone-precipitated withdrawal in rats and hamsters

Tolerance of locus coeruleus neurones to morphine and suppression of withdrawal response by clonidine

1978 • 794 citations

CLONIDINE BLOCKS ACUTE OPIATE-WITHDRAWAL SYMPTOMS

1978 • 705 citations

Goodman and Gilman's The Pharmacological Basis of Therapeutics.

1981 • 339 citations

Effects of divalent cations, cation chelators and an ionophore on morphine analgesia and tolerance.

1975 • 194 citations

Effects of clonidine on morphine withdrawal signs in the rat

1975 • 177 citations

Calcium channel inhibitors suppress the morphine‐withdrawal syndrome in rats

1986 • 146 citations

Effects of acute and chronic morphine treatments on calcium localization and binding in brain.

1978 • 141 citations

Clonidine infusions into the locus coeruleus attenuate behavioral and neurochemical changes associated with naloxone-precipitated withdrawal

1988 • 132 citations

Calcium channel antagonists increase morphine-induced analgesia and antagonize morphine tolerance

1988 • 130 citations

The combined use of clonidine and naltrexone as a rapid, safe, and effective treatment of abrupt withdrawal from methadone

1986 • 122 citations

Metal Ion Interactions with Opiates

1980 • 121 citations

Prolonged morphine treatment increases rat brain dihydropyridine binding sites: possible involvement in development of morphine dependence

1988 • 107 citations

Effect of morphine on synaptosomal Ca++ uptake.

1979 • 105 citations

Species differences in the concentrations and distributions of opioid binding sites

1985 • 99 citations

Discrete changes in brain calcium with morphine analgesia, tolerance-dependence, and abstinence

1977 • 98 citations

Calcium agonists and antagonists of the dihydropyridine type: Antinociceptive effects, interference with opiate-?-receptor agonists and neuropharmacological actions in rodents

1986 • 98 citations

Effects of peripheral and central administration of calcium channel blocker in the naloxone-precipitated abstinence syndrome in morphine-dependent rats

1987 • 90 citations

Potentiation of thermoregulatory and analygesic effects of morphine by calcium antagonists

1984 • 87 citations

Increase in [3H]nitrendipine binding sites in the brain in morphine-tolerant mice

1984 • 81 citations

Clonidine reverses the increased norepinephrine turnover during morphine withdrawal in rats

1980 • 76 citations

A comparison of the inhibitory effects of clonidine and guanfacine on the behavioral and autonomic components of morphine withdrawal in rats

1984 • 52 citations

Stimulatory influences of calcium channel antagonists on stress-induced opioid analgesia and locomotor activity

1987 • 45 citations

Reproducible Withdrawal Contractions of Isolated Guinea-pig Ileum after Brief Morphine Exposure: Effects of Clonidine and Nifedipine

1990 • 44 citations

Social, motor, and autonomic signs of morphine withdrawal: differential sensitivities to catecholaminergic drugs in mice

1988 • 44 citations

Clonidine suppression of noradrenergic hyperactivity during morphine withdrawal by clonidine: biochemical studies in rodents and primates.

1982 • 37 citations

Differential effects of L-type calcium channel blockers and stimulants on naloxone-precipitated withdrawal in mice acutely dependent on morphine

1991 • 37 citations

Participation of different brain regions in the anti-narcotic withdrawal action of clonidine in the dependent rat

1990 • 34 citations

Differential effects of calcium channel blockers and stimulants on morphine withdrawal in vitro

1988 • 30 citations

Interaction of κ receptor agonists with Ca2+ channel antagonists in the modulation of hypothermia

1986 • 27 citations

Enhancement of morphine-withdrawal and apomorphine-induced aggression by clonidine.

1976 • 26 citations

Suppression of small intestinal motility and morphine withdrawal diarrhoea by clonidine: peripheral site of action

1989 • 26 citations

Changes in locomotor-activity patterns as a measure of spontaneous morphine withdrawal: no effect of clonidine

1988 • 24 citations

Dose-dependent and stereoselective antagonism by diltiazem of naloxone-precipitated morphine abstinence after acute morphine-dependence and

1988 • 24 citations

Effect of clonidine, nimodipine and diltiazem on the in vitro opioid withdrawal response in the guinea‐pig ileum

1990 • 20 citations

Morphine dependent rats: Blockade of precipitated abstinence by calcium

1976 • 18 citations

Acute morphine dependence in the hamster

1991 • 17 citations

Conditioned morphine withdrawal in the hamster

1992 • 17 citations

[Characterization of opioid receptors in the golden hamster brain].

1986 • 3 citations