Molecular Analysis of Putative Pneumococcal Virulence Proteins

Many pulmonary pathogenic bacteria bind specifically to the carbohydrate sequence GalNAc beta 1-4Gal found in some glycolipids.

1988 • 396 citations

Contribution of autolysin to virulence of Streptococcus pneumoniae

1989 • 261 citations

Sequence heterogeneity of PsaA, a 37-kilodalton putative adhesin essential for virulence of Streptococcus pneumoniae

1996 • 261 citations

MOLECULAR ANALYSIS OF THE PATHOGENICITY OF STREPTOCOCCUS PNEUMONIAE: The Role of Pneumococcal Proteins

1993 • 259 citations

Pyruvate oxidase, as a determinant of virulence in Streptococcus pneumoniae

1996 • 258 citations

A binding protein-dependent transport system in Streptococcus mutans responsible for multiple sugar metabolism.

1992 • 240 citations

Use of insertional inactivation to facilitate studies of biological properties of pneumococcal surface protein A (PspA).

1987 • 214 citations

Effect of immunization with pneumolysin on survival time of mice challenged with Streptococcus pneumoniae

1983 • 205 citations

Conserved sequences in bacterial and viral sialidases

1989 • 181 citations

Cloning and nucleotide sequence analysis of psaA, the Streptococcus pneumoniae gene encoding a 37-kilodalton protein homologous to previously reported Streptococcus sp. adhesins

1994 • 148 citations

A neuraminidase from Streptococcus pneumoniae has the features of a surface protein

1994 • 142 citations

Protection of mice against fatal pneumococcal challenge by immunization with pneumococcal surface adhesin A (PsaA)

1996 • 136 citations

The contribution of pneumolysin to the pathogenicity of Streptococcus pneumoniae

1996 • 136 citations

Structure and function of pneumolysin, the multifunctional, thiol‐activated toxin of Streptococcus pneumoniae

1991 • 126 citations

Peptide permeases from Streptococcus pneumoniae affect adherence to eucaryotic cells

1995 • 121 citations

Truncated forms of PspA that are secreted from Streptococcus pneumoniae and their use in functional studies and cloning of the pspA gene

1992 • 116 citations

Cloning and nucleotide sequence of the Streptococcus pneumoniae hyaluronidase gene and purification of the enzyme from recombinant Escherichia coli

1994 • 113 citations

Comparative efficacy of pneumococcal neuraminidase and pneumolysin as immunogens protective against Streptococcus pneumoniae

1988 • 110 citations

Nucleotide sequence of the Streptococcus gordonii PK488 coaggregation adhesin gene, scaA, and ATP-binding cassette

1994 • 108 citations

ThefimAlocus ofStreptococcus parasanguisencodes an ATP‐binding membrane transport system

1995 • 102 citations

Cloning and characterization of nanB, a second Streptococcus pneumoniae neuraminidase gene, and purification of the NanB enzyme from recombinant Escherichia coli

1996 • 92 citations

Nucleotide sequence of a gene coding for a saliva-binding protein (SsaB) from Streptococcus sanguis 12 and possible role of the protein in coaggregation with actinomyces

1991 • 88 citations

Comparative efficacy of autolysin and pneumolysin as immunogens protecting mice against infection by Streptococcus pneumoniae

1992 • 86 citations

Effect of insertional inactivation of the genes encoding pneumolysin and autolysin on the virulence of Streptococcus pneumoniae type 3

1992 • 83 citations

Nucleotide sequence analysis of a type 1 fimbrial gene of Streptococcus sanguis FW213

1989 • 79 citations

Monoclonal antibody recognizing a species-specific protein from Streptococcus pneumoniae

1990 • 76 citations

Neuraminidase activity in bacterial meningitis

1971 • 72 citations

A 43-kilodalton pneumococcal surface protein, PspA: isolation, protective abilities, and structural analysis of the amino-terminal sequence

1991 • 56 citations

Purification and immunological characterization of neuraminidase produced by Streptococcus pneumoniae

1988 • 55 citations

Roles of autolysin and pneumolysin in middle ear inflammation caused by a type 3 Streptococcus pneumoniae strain in the chinchilla otitis media model

1996 • 47 citations