Identification in mammalian brain of an endogenous substance with Na+ channel blocking activities similar to those of tetrodotoxin

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

Regressive Events in Neurogenesis

1984 • 1,330 citations

Peptide Neurotoxins from Fish-Hunting Cone Snails

1985 • 742 citations

MOLECULAR PROPERTIES OF VOLTAGE-SENSITIVE SODIUM CHANNELS

1986 • 577 citations

Conus geographus toxins that discriminate between neuronal and muscle sodium channels.

1985 • 402 citations

The binding of saxitoxin and tetrodotoxin to excitable tissue

1977 • 369 citations

Principal glycopeptide of the tetrodotoxin/saxitoxin binding protein from Electrophorus electricus: isolation and partial chemical and physical characterization

1983 • 264 citations

The coexistence in rat muscle cells of two distinct classes of Ca2+-dependent K+ channels with different pharmacological properties and different physiological functions

1984 • 191 citations

Saxitoxin binding to synaptosomes, membranes, and solubilized binding sites from rat brain

1979 • 116 citations

Molecular properties of the action potential Na+ ionophore in neuroblastoma cells. Interactions with neurotoxins.

1978 • 109 citations

Characterization, solubilization, affinity labeling and purification of the cardiac Na+ channel using Tityus toxin gamma

1984 • 99 citations

Synthesis of New, Highly Radioactive Tetrodotoxin Derivatives and Their Binding Properties to the Sodium Channel

1980 • 93 citations

Electrophysiological characterization, solubilization and purification of the Tityus gamma toxin receptor associated with the gating component of the Na+ channel from rat brain.

1983 • 77 citations

Specific inhibition of [3H] saxitoxin binding to skeletal muscle sodium channels by geographutoxin II, a polypeptide channel blocker.

1986 • 69 citations

Occurrence and Origin of Tetrodotoxin

1984 • 66 citations

Polypeptide Toxins as Tools to Study Voltage‐Sensitive Na⁺ Channels^a

1986 • 63 citations

Na⁺ Channels with Binding Sites of High and Low Affinity for Tetrodotoxin in Different Excitable and Non‐excitable Cells

1982 • 62 citations

Immunoaffinity isolation of Na+ channels from rat skeletal muscle. Analysis of subunits.

1986 • 57 citations

The presence in pig brain of an endogenous equivalent of apamin, the bee venom peptide that specifically blocks Ca2+-dependent K+ channels.

1984 • 54 citations

A cardiac tetrodotoxin-binding component: biochemical identification, characterization, and properties

1981 • 52 citations

Differentiation of the fast Na+ channel in embryonic heart cells: interaction of the channel with neurotoxins.

1981 • 40 citations

A convenient bioassay for detecting nanomolar concentrations of tetrodotoxin

1973 • 29 citations

Historical Perspective on Paralytic Shellfish Poison

1984 • 24 citations

Affinity labelling of the tetrodotoxin-binding component of the Na+ channel

1983 • 17 citations

Pharmacology of Nerve Membrane Sodium Channels

1984 • 11 citations