Virus or a hapten‐carrier complex can activate autoreactive B cells by providing linked T help

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Rheumatoid Arthritis

1990 • 1,565 citations

Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice

1988 • 1,562 citations

Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes

1989 • 1,015 citations

Therapy with monoclonal antibodies by elimination of T-cell subsets in vivo

1984 • 884 citations

Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens

1991 • 694 citations

The Biology and Detection of Immune Complexes

1980 • 463 citations

Chemically synthesized peptides predicted from the nucleotide sequence of the hepatitis B virus genome elicit antibodies reactive with the native envelope protein of Dane particles.

1981 • 412 citations

Peripheral deletion of self-reactive B cells

1991 • 353 citations

Specificities of antibodies to acetylcholine receptors in sera from myasthenia gravis patients measured by monoclonal antibodies.

1982 • 342 citations

Origin of Thy-1+ dendritic epidermal cells of adult mice from fetal thymic precursors

1990 • 306 citations

Immunological Unresponsiveness

1973 • 278 citations

Somatic mutations in the variable regions of a human IgG anti-double-stranded DNA autoantibody suggest a role for antigen in the induction of systemic lupus erythematosus.

1991 • 246 citations

Induction of Self-Rolerance in T Cells But Not B Cells of Transgenic Mice Expressing Little Self Antigen

1991 • 211 citations

THE IMMUNE RESPONSE OF RABBITS TOLERANT TO BOVINE SERUM ALBUMIN TO THE INJECTION OF OTHER HETEROLOGOUS SERUM ALBUMINS

1961 • 144 citations

Reconstitution into liposomes of the glycoprotein of vesicular stomatitis virus by detergent dialysis.

1979 • 138 citations

Virus-induced autoantibody response to a transgenic viral antigen

1990 • 130 citations

Regulatory Mechanisms in the Immune Response to Cell-surface Antigens

1977 • 118 citations

A natural model of immunologic tolerance. Tolerance to murine C5 is mediated by T cells, and antigen is required to maintain unresponsiveness.

1982 • 74 citations

Collagen autoimmunity and arthritis

1988 • 62 citations

Primary antibody responses to a well-defined and unique hapten are not enhanced by preimmunization with carrier: analysis in a viral model.

1986 • 50 citations

Monoclonal ant-idiotypic antibodies reactive with a highly conserved determinant on A/J serum anti-para-azophenylarsonate antibodies.

1981 • 35 citations

T cell immunity or tolerance as a consequence of self antigen presentation

1989 • 33 citations

Immunology of reaginic allergy: in vitro studies.

1970 • 25 citations