Benzothiazepinone Binding Domain of Purified L-Type Calcium Channels: Direct Labeling Using a Novel Fluorescent Diltiazem Analog

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1973 • 12,522 citations

Energy transfer: a spectroscopic ruler.

1967 • 1,865 citations

Mechanism of calcium channel blockade by verapamil, D600, diltiazem and nitrendipine in single dialysed heart cells

1983 • 869 citations

Interaction of tetrandrine with slowly inactivating calcium channels. Characterization of calcium channel modulation by an alkaloid of Chinese medicinal herb origin.

1988 • 153 citations

Dihydropyridine receptor of L-type Ca2+ channels: identification of binding domains for [3H](+)-PN200-110 and [3H]azidopine within the alpha 1 subunit.

1991 • 144 citations

Purification of a functional receptor for calcium‐channel blockers from rabbit skeletal‐muscle microsomes

1986 • 107 citations

Binding of Ca2+ entry blockers to cardiac sarcolemmal membrane vesicles. Characterization of diltiazem-binding sites and their interaction with dihydropyridine and aralkylamine receptors.

1986 • 102 citations

Temperature‐dependent regulation of d‐cis‐[³H]diltiazem binding to Ca²⁺ channels by 1,4‐dihydropyridine channel agonists and antagonists

1983 • 96 citations

(-)-[3H] desmethoxyverapamil labels multiple calcium channel modulator receptors in brain and skeletal muscle membranes: differentiation by temperature and dihydropyridines.

1986 • 92 citations

In vivo labeling of L-type Ca2+ channels by fluorescent dihydropyridines: evidence for a functional, extracellular heparin-binding site.

1992 • 89 citations

Purified calcium channels have three allosterically coupled drug receptors

1986 • 75 citations

Calcium channels from Cyprinus carpio skeletal muscle.

1991 • 70 citations

Benzazepinone calcium channel blockers. 2. Structure activity and drug metabolism studies leading to potent antihypertensive agents. Comparison with benzothiazepinones

1992 • 68 citations

Target size analysis and molecular properties of Ca²⁺ channels labelled with [³H]verapamil

1984 • 62 citations

Extracellular localization of the benzothiazepine binding domain of L-type Ca2+ channels.

1993 • 48 citations

A unique fluorescent phenylalkylamine probe for L-type Ca2+ channels. Coupling of phenylalkylamine receptors to Ca2+ and dihydropyridine binding sites.

1992 • 45 citations

Benzazepinone calcium channel blockers. 4. Structure-activity overview and intracellular binding site

1992 • 44 citations

Identification of the benzothiazepine-binding polypeptide of skeletal muscle calcium channels with (+)-cis-azidodiltiazem and anti-ligand antibodies.

1990 • 43 citations

Photoaffinity labeling of the purified skeletal muscle calcium antagonist receptor by a novel benzothiazepine, [3H]azidobutyryl diltiazem

1989 • 41 citations

Ligand-induced accelerated dissociation of (+)-cis-diltiazem from L-type Ca2+ channels is simply explained by competition for individual attachment points.

1993 • 36 citations

A light stabilizer (Tinuvin 770) that elutes from polypropylene plastic tubes is a potent L-type Ca(2+)-channel blocker.

1993 • 35 citations

Complex Molecular Mechanism for Dihydropyridine Binding to L-Type Ca2+-Channels As Revealed by Fluorescence Resonance Energy Transfer

1994 • 31 citations

The devapamil‐binding site of the purified skeletal muscle receptor for organic‐calcium channel blockers is modulated by micromolar and millimolar concentrations of Ca²⁺

1991 • 17 citations

Purification of L-Type Calcium Channel Drug Receptors

1991 • 16 citations

Structure of Calcium Channels^a

1989 • 12 citations