A long-acting silicone delivery system for morphine and naloxone administration

A simplified method of evaluating dose-effect experiments.

1948 • 7,047 citations

Synthetic analgesics. II. Dithienylbutenyl- and dithienylbutylamines.

1953 • 1,702 citations

Simultaneous quantitative assessment of morphine tolerance and physical dependence.

1969 • 681 citations

Development of physical dependence on morphine in respect to time and dosage and quantification of the precipitated withdrawal syndrome in rats

1973 • 523 citations

Morphine Tolerance, Physical Dependence, and Synthesis of Brain 5-Hydroxytryptamine

1968 • 259 citations

Formulation of a Morphine Implantation Pellet Suitable for Tolerance-Physical Dependence Studies in Mice

1970 • 223 citations

Inhibition of morphine tolerance and physical dependence development and brain serotonin synthesis by cycloheximide

1969 • 116 citations

Long-acting delivery systems for narcotic antagonists. 1

1973 • 95 citations

An implanted reservoir of morphine solution for rapid induction of physical dependence in rats

1971 • 82 citations

Production of Hypertension with Desoxycorticosterone Acetate-Impregnated Silicone Rubber Implants

1973 • 80 citations

Relationship of brain morphine levels to analgesic activity in acutely treated mice and rats and in pellet implanted mice.

1975 • 71 citations

Pharmacological Aspects of Drug Dependence

1964 • 62 citations

Administration of pellets of morphine to mice; abstinence syndrome.

1961 • 59 citations

A comparison of withdrawal in rats implanted with different types of morphine pellets

1976 • 23 citations

Reduced threshold to pain induced aggression specifically related to morphine dependence

1974 • 17 citations

Establishment of physical dependence mice by oral ingestion of morphine.

1974 • 6 citations

Insoluble salts and salt complexes of cyclazocine and naloxone.

1973 • 3 citations

Design consideration for long-acting antagonists.

1973 • 2 citations