Current St. John's wort research from mode of action to clinical efficacy

Placebo Response in Studies of Major Depression

2002 • 1,106 citations

St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor

2000 • 929 citations

St John's Wort induces intestinal P-glycoprotein/MDR1 and intestinal and hepatic CYP3A4

2000 • 587 citations

Effect of Hypericum perforatum (St John's Wort) in Major Depressive Disorder

2002 • 470 citations

Hyperforin as a possible antidepressant component of hypericum extracts

1998 • 445 citations

Inhibition of human cytochrome P450 enzymes by constituents of St. John's Wort, an herbal preparation used in the treatment of depression.

2000 • 400 citations

Effectiveness of St John's Wort in Major Depression

2001 • 380 citations

Flavonoids from Hypericum perforatum Show Antidepressant Activity in the Forced Swimming Test

2000 • 364 citations

St. John's wort (Hypericum perforatum): a review of the current pharmacological, toxicological, and clinical literature

2001 • 361 citations

St. John's Wort in Mild to Moderate Depression: The Relevance of Hyperforin for the Clinical Efficacy

1998 • 329 citations

St John's Wort for Depression

2000 • 323 citations

Effects of Hypericum Extract (LI 160) in Biochemical Models of Antidepressant Activity

1997 • 281 citations

Hyperforin Represents the Neurotransmitter Reuptake Inhibiting Constituent of Hypericum Extract

1998 • 269 citations

St John's wort: Prozac from the plant kingdom

2001 • 265 citations

Hyperforin, a major antidepressant constituent of St. John's Wort, inhibits serotonin uptake by elevating free intracellular Na+1.

1999 • 230 citations

St. John's wort and depression

2002 • 191 citations

Efficacy of St. John’s Wort Extract WS 5570 in Major Depression: A Double-Blind, Placebo-Controlled Trial

2002 • 190 citations

Saint John's wort: An in vitro analysis of P‐glycoprotein induction due to extended exposure

2001 • 174 citations

Hyperforin - Antidepressant Activity by a Novel Mechanism of Action

2001 • 128 citations

Inhibition of Synaptosomal Uptake of 3H-L-glutamate and 3H-GABA by Hyperforin, a Major Constituent of St. John's Wort The Role of Amiloride Sensitive Sodium Conductive Pathways

2000 • 118 citations

Predictive value of pharmacological activity for the relative efficacy of antidepressant drugs

2000 • 108 citations

Activity Profiles of Two Hyperforin-Containing Hypericum Extracts in Behavioral Models

1998 • 97 citations

The experimental and clinical pharmacology of St John's Wort (Hypericum perforatum L.)

1999 • 96 citations

Adhyperforin as a contributor to the effect of Hypericum perforatum L. in biochemical models of antidepressant activity

2001 • 94 citations

Serotonin, Norepinephrine and Dopamine Involvement in the Antidepressant Action of Hypericum Perforatum

2001 • 88 citations

St John's wort, hypericin, and imipramine: a comparative analysis of mRNA levels in brain areas involved in HPA axis control following short-term and long-term administration in normal and stressed rats

2001 • 85 citations

Serum dopamine β-hydroxylase as an index of sympathetic function

1974 • 81 citations

Hypericum perforatum L. extract does not inhibit 5-HT transporter in rat brain cortex

1999 • 80 citations

Hypericum perforatum - a Review of Clinical Studies

2001 • 74 citations

Evaluation of Synaptosomal Uptake Inhibition of most Relevant Constituents of St. John's Wort

2001 • 69 citations

Hypericum Extract and Hyperforin: Memory-Enhancing Properties in Rodents

2001 • 66 citations

Evidence That Total Extract of Hypericum perforatum Affects Exploratory Behavior and Exerts Anxiolytic Effects in Rats

2000 • 59 citations

In Vitro Binding Studies with Two Hypericum Perforatum Extracts - Hyperforin, Hypericin and Biapigenin - on 5-HT6, 5-HT7, GABAA/Benzodiazepine, Sigma, NPY-Y1 /Y2 Receptors and Dopamine Transporters

2001 • 56 citations

A Study of the Antidepressant Activity of HypericumPerforatum on AnimalModels

2001 • 50 citations

Pharmacological and Endocrine Effects of Hypericum Perforatum and Hypericin After Repeated Treatment

2001 • 45 citations

Cluster analysis of symptoms during antidepressant treatment with Hypericum extract in mildly to moderately depressed out-patients. A meta-analysis of data from three randomized, placebo-controlled trials

2002 • 45 citations

Plasma pharmacokinetics and cerebrospinal fluid penetration of hypericin in nonhuman primates

2000 • 40 citations

Researching the Antidepressant Actions of Hypericum Perforatum (St. John’s wort) in Animals and Man

2001 • 34 citations

Acute and Chronic Actions of a dry methanolic extract of Hypericum Perforatum and a Hyperforin-Rich Extract on Dopaminergic and Serotonergic Neurones in Rat Nucleus Accumbens

2001 • 23 citations

Effects of Hypericum perforatum (St. John’s wort) on Passive Avoidance in the Rat: Evaluation of Potential Neurochemical Mechanisms Underlying its Antidepressant Activity

2001 • 23 citations

Efficacy and Tolerability of Ze 117 St. John's Wort Extract in Comparison with Placebo, Imipramine and Fluoxetine for the Treatment of Mild to Moderate Depression according to ICD-10. An Overview

2001 • 17 citations

In Vivo Neurotransmitter Release in the Locus Coeruleus - Effects of Hyperforin, Inescapable Shock and Fear

2001 • 15 citations

The Effects of Extracts from St. John's Wort and Kava Kava on Brain Neurotransmitter Levels in the Mouse

2001 • 13 citations

Mechanismen der Interaktionen mit Johanniskrautextrakten

2000 • 6 citations