Structure and regulation of the glucocorticoid hormone receptor

Glucocorticoid receptors: Relations between steroid binding and biological effects

1972 • 554 citations

Common non-hormone binding component in non-transformed chick oviduct receptors of four steroid hormones

1984 • 442 citations

Glucocorticoid Hormone Action

1979 • 434 citations

RU 38486: Potent antiglucocorticoid activity correlated with strong binding to the cytosolic glucocorticoid receptor followed by an impaired activation

1984 • 372 citations

Evidence that the endogenous heat-stable glucocorticoid receptor-activating factor is thioredoxin.

1983 • 309 citations

Purification of the glucocorticoid receptor from rat liver cytosol.

1979 • 239 citations

Activation of the glucocorticoid-receptor complex

1982 • 224 citations

Glucocorticoid-receptor complexes and the earliest steps in the action of glucocorticoids on thymus cells

1972 • 206 citations

Direct demonstration of glucocorticoid receptor phosphorylation by intact L-cells.

1983 • 200 citations

Regulation of Glucocorticoid Receptors by Glucocorticoids in Cultured HeLa S₃Cells*

1981 • 191 citations

Diploid and haploid states of the glucocorticoid receptor gene of mouse lymphoid cell lines

1977 • 170 citations

Glucocorticoid receptors and glucocorticoid sensitivity of mitogen stimulated and unstimulated human lymphocytes

1977 • 166 citations

Characterization of nonactivated and activated glucocorticoid-receptor complexes from intact rat thymus cells.

1983 • 162 citations

Steroid-binding properties and stabilization of cytoplasmic glucocorticoid receptors from rat thymus cells

1973 • 155 citations

Activation of steroid hormone–receptor complexes in intact target cells in physiological conditions

1979 • 152 citations

The glucocorticoid receptor in GH1 cells. Evidence from dense amino acid labeling and whole cell studies for an equilibrium model explaining the influence of hormone on the intracellular distribution of receptor.

1983 • 150 citations

Regulation of the glucocorticoid receptor in human lymphocytes

1982 • 148 citations

Steroid hormone receptors and pharmacology

1980 • 139 citations

Photoaffinity labeling of glucocorticoid receptors.

1981 • 117 citations

Monoclonal antibodies to the rat liver glucocorticoid receptor.

1982 • 113 citations

Alteration in glucocorticoid binding site number during the cell cycle in HeLa cells

1977 • 107 citations

Inactivation of glucocorticoid-binding capacity by protein phosphatases in the presence of molybdate and complete reactivation of dithiothreitol.

1982 • 106 citations

Nature of steroid-glucocorticoid receptor interactions: thermodynamic analysis of the binding reaction

1978 • 105 citations

17α-Alkynyl-11β,17-dihydroxyandrostane derivatives : A new class of potent glucocorticoids.

1981 • 94 citations

The involvement of receptor sulphydryl groups in the binding of steroids to the cytoplasmic glucocorticoid receptor from rat thymus

1975 • 93 citations

Effects of RNA and ribonuclease on the binding of estrogen and glucocorticoid receptors from MCF-7 cells to DNA-cellulose.

1982 • 93 citations

Activation of covalent affinity labeled glucocorticoid receptor-steroid complexes.

1983 • 92 citations

Activation of liver and kidney glucocorticoid-receptor complexes occurs in vivo

1980 • 91 citations

Mode of entry of steroid and thyroid hormones into cells

1981 • 90 citations

Interaction of steroids with hepatoma cells: Molecular mechanisms of glucocorticoid hormone action

1975 • 89 citations

The Transport of Steroids into Animal Cells in Culture

1981 • 89 citations

Purification of Two Dexamethasone-Binding Proteins from Rat-Liver Cytosol

1978 • 88 citations

A kinetic analysis of the estrogen receptor transformation.

1975 • 86 citations

Glucocorticoid receptor activation and inactivation in cultured human lymphocytes.

1981 • 83 citations

Active domains in wild-type and mutant glucocorticoid receptors.

1982 • 78 citations

The Effects of Ribonuclease on Rat Liver Dexamethasone Receptor: Increased Affinity for Deoxyribonucleic Acid and Altered Sedimentation Profile*

1983 • 75 citations

Immunofluorescence microscopy of the intracellular translocation of glucocorticoid-receptor complexes in rat hepatoma (HTC) cells

1980 • 75 citations

Ontogeny of Rat Hepatic Glucocorticoid Receptors

1974 • 74 citations

Photoaffinity labeling and partial proteolysis of wild-type and variant glucocorticoid receptors

1983 • 74 citations

Chromosome assignment of a murine glucocorticoid receptor gene (Grl-1) using intraspecies somatic cell hybrids

1980 • 72 citations

Steroid flexibility and receptor specificity

1980 • 70 citations

Transformation of mammary cytoplasmic glucocorticoid receptor under cell-free conditions

1981 • 69 citations

Glucocorticoid Receptors: Evidence for a Second, Non-Glucocorticoid Binding Site

1976 • 68 citations

Characteristics of an endogenous glucocorticoid receptor stabilizing factor.

1982 • 62 citations

Molybdate permits resolution of untransformed glucocorticoid receptors from the transformed state.

1981 • 60 citations

Chemical Probes of Amino Acid Residues Affect the Active Sites of the Glucocorticoid Receptor*

1980 • 55 citations

Progesterone Enhances Glucocorticoid Dissociation from the AtT-20 Cell Glucocorticoid Receptor*

1980 • 54 citations

Progress in Research and Clinical Applications of Corticosteroids

1982 • 52 citations

Limited proteolysis of the mouse liver glucocorticoid receptor

1983 • 51 citations

17β- Carboxamide steroids are a new class of glucocorticoid antagonists

1979 • 51 citations

Modulation of glucocorticoid effects and steroid receptor binding in butyrate-treated HeLa S3 cells

1980 • 50 citations

Changes in Specific Dexamethasone Binding during Aging in WI-38 Cells*

1981 • 49 citations

Activated and non-activated glucocorticoid-receptor complexes in rat thymus cells: Kinetics of formation and relation to steroid structure

1980 • 48 citations

Endocrinology: New model for steroid hormone receptors?

1984 • 45 citations

Changes in the intracellular levels of pyridoxal 5′-phosphate affect the induction of tyrosine aminotransferase by glucocorticoids

1981 • 44 citations

Hepatic glucocorticoid receptors and the H–2 locus

1978 • 38 citations

Binding of glucocorticoid 21-OIC acids and esters to molybdate-stabilized hepatic receptors

1981 • 38 citations

Absence in glucocorticoid-resistant mouse lymphoma P1798 of a glucocorticoid receptor domain responsible for biological effects.

1983 • 38 citations

Heterogeneity of the in vitro responses to glucocorticoids in acute leukemia.

1980 • 37 citations

The Activated Glucocorticoid Receptor of Rat Liver

1980 • 37 citations

Glucocorticoid-receptor interactions. Studies of the negative co-operativity induced by steroid interactions with a secondary, hydrophobic, binding site

1980 • 37 citations

Thermodynamics of steroid binding to the human glucocorticoid receptor

1984 • 36 citations

Diphenylhydantoin: An Alternative Ligand of a Glucocorticoid Receptor Affecting Prostaglandin Generation in A/J Mice

1982 • 36 citations

MONOCLONAL ANTIBODIES TO THE GLUCOCORTICOID RECEPTOR

1982 • 35 citations

Purification of rat liver glucocorticoid receptor by affinity chromatography: Design of a suitable adsorbent

1981 • 33 citations

Deacylcortivazol acts through glucocorticoid receptors

1981 • 32 citations

Ontogeny of the glucocorticoid receptor and its relationship to tyrosine aminotransferase induction in cultured foetal hepatocytes

1981 • 31 citations

Development of glucocorticoid antagonists

1983 • 27 citations

Progesterone as a partial glucocorticoid agonist in L929 mouse fibroblasts: Effects on cell growth, glutamine synthetase induction and glucocorticoid receptors

1981 • 26 citations

Physiochemical characterization of rat liver glucocorticoid receptor during development.

1982 • 25 citations

The proviral DNA of mouse mammary tumor virus: Its use in the study of the molecular details of steroid hormone action

1983 • 25 citations

Modulation of cortisol receptors in embryonic retina cells by changes in cell-cell contacts: Correlations with induction of glutamine synthetase

1981 • 24 citations

DISSOCIATION BETWEEN THE MAGNITUDE OF NUCLEAR BINDING AND THE BIOPOTENCY OF GLUCOCORTICOIDS*

1982 • 23 citations

Calmodulin antagonists competitively inhibit dexamethasone binding to the glucocorticoid receptor

1982 • 22 citations

Characterization of the molybdate-stabilized glucocorticoid receptor from rat thymus

1982 • 21 citations

Interrelations between glucocorticoid and progestin receptors

1981 • 20 citations

Concanavalin A-induced glucocorticoid resistance in rat thymus cells: Decreased cytoplasmic and nuclear receptor binding of dexamethasone

1976 • 20 citations

Dissociation kinetics of the estrogen receptor immobilized by hydroxylapatite

1981 • 20 citations

Competitive inhibition of dexamethasone binding to the glucocorticoid receptor in HTC cells by tryptophan methyl ester

1980 • 19 citations

An H-2 linked difference in the binding of dexamethasone to murine hepatic cytosol receptor a possible role of endogenous modifier(s)

1981 • 18 citations

Submicromolar free calcium modulates dexamethasone binding to the glucocorticoid receptor

1982 • 16 citations

Glucocorticoid agonist and antagonist activity of 17,21-acetonide steroids

1983 • 14 citations

The endogenous heat-stable glucocorticoid receptor stabilizing factor and the H-2 locus

1982 • 13 citations

Nonactivated and activated glucocorticoid-receptor complexes in WEHI-7 and rat thymus cells

1984 • 11 citations

Nuclear localization of a glucocorticoid antagonist in cultured hepatoma cells

1983 • 10 citations

Steroid derivatives for electrophilic affinity labelling of glucocorticoid binding sites: Interaction with the glucocorticoid receptor and biological activity

1983 • 9 citations

Effects of membrane-active compounds on dexamethasone binding to the glucocorticoid receptor in intact cells

1984 • 7 citations

Purification and structure of a new nucleotide from Proteus mirabilis that amplifies induction of tyrosine aminotransferase by glucocorticoid

1979 • 7 citations

Binding of some non-steroidal anti-inflammatory drugs to glucocorticoid receptors in vitro

1978 • 5 citations

5′-Deoxypyridoxal inhibition of glucocorticoid receptor binding in HeLa S3 cells and rat thymocytes

1980 • 5 citations