To combine or not to combine? A literature review of antidepressant combination therapy

Sequenced treatment alternatives to relieve depression (STAR*D): rationale and design

2004 • 1,017 citations

Residual symptoms after partial remission: an important outcome in depression

1995 • 801 citations

DEFINITION AND EPIDEMIOLOGY OF TREATMENT-RESISTANT DEPRESSION

1996 • 764 citations

The definition and meaning of treatment-resistant depression.

2001 • 751 citations

When at first you don't succeed: sequential strategies for antidepressant nonresponders.

1997 • 712 citations

Background and rationale for the Sequenced Treatment Alternatives to Relieve Depression (STAR∗D) study

2003 • 525 citations

Residual Symptoms in Depressed Patients Who Respond Acutely to Fluoxetine

1999 • 463 citations

The role and clinical significance of subsyndromal depressive symptoms (SSD) in unipolar major depressive disorder

1997 • 446 citations

Treatment resistant depression: methodological overview and operational criteria

1999 • 425 citations

The Maudsley Prescribing Guidelines

2007 • 377 citations

Essential Psychopharmacology: Neuroscientific Basis and Practical Applications

1996 • 374 citations

The Increasing Use of Polypharmacotherapy for Refractory Mood Disorders

2000 • 319 citations

Texas Medication Algorithm Project

1998 • 261 citations

Essential Psychopharmacology: Neuroscientific Basis and Practical Applications

2001 • 251 citations

A double-blind, placebo-controlled study of antidepressant augementation with mirtazapine

2002 • 244 citations

Lithium and tricyclic augmentation of fluoxetine treatment for resistant major depression: a double-blind, controlled study

1994 • 230 citations

The Burden of Major Depression Avoidable by Longer-term Treatment Strategies

2004 • 215 citations

Combining norepinephrine and serotonin reuptake inhibition mechanisms for treatment of depression: a double-blind, randomized study

2004 • 182 citations

Augmentation and combination strategies in treatment-resistant depression.

2001 • 144 citations

Pindolol and Mianserin Augment the Antidepressant Activity of Fluoxetine in Hospitalized Major Depressed Patients, Including Those With Treatment Resistance

1999 • 140 citations

Partial Response, Nonresponse, and Relapse With Selective Serotonin Reuptake Inhibitors in Major Depression

2000 • 138 citations

Mirtazapine Augmentation in the Treatment of Refractory Depression

1999 • 134 citations

Combining Bupropion SR With Venlafaxine, Paroxetine, or Fluoxetine

2002 • 132 citations

Medication Treatment for the Severely and Persistently Mentally Ill

1999 • 131 citations

Double-Blind Study of High-Dose Fluoxetine Versus Lithium or Desipramine Augmentation of Fluoxetine in Partial Responders and Nonresponders to Fluoxetine

2002 • 129 citations

Dopamine antagonists in tic-related and psychotic spectrum obsessive compulsive disorder.

1994 • 123 citations

Treatment strategies in patients with major depression not responding to first-line sertraline treatment

2002 • 112 citations

Benefits from mianserin augmentation of fluoxetine in patients with major depression non‐responders to fluoxetine alone

2001 • 97 citations

A Comparison of Electroconvulsive Therapy and Combined Phenelzine-Amitriptyline in Refractory Depression

1978 • 96 citations

A Prospective Trial of Bupropion SR Augmentation of Partial and Non-Responders to Serotonergic Antidepressants

2003 • 89 citations

Citalopram and Bupropion-SR

2004 • 87 citations

Augmentation strategies in depression 2000.

2000 • 69 citations

Non-response to citalopram in depressive patients: pharmacokinetic and clinical consequences of a fluvoxamine augmentation

1996 • 67 citations

Algorithm for the treatment of chronic depression.

2001 • 62 citations

Benefits from mianserin augmentation of fluoxetine in patients with major depression non-responders to fluoxetine alone

2001 • 60 citations

Enhancing outcomes in the management of treatment resistant depression: a focus on atypical antipsychotics

2003 • 57 citations

Use of bupropion with SRIs and venlafaxine

1998 • 54 citations

A 3-year follow-up

1992 • 50 citations

Predictors of Response to Lithium and Triiodothyronine Augmentation of Antidepressants in Tricyclic Non-responders

1993 • 48 citations

The efficacy of fluoxetine combined with a heterocyclic antidepressant in treatment-resistant depression: a retrospective analysis.

1995 • 44 citations

American Psychiatric Association -- 157th Annual Meeting.

2004 • 42 citations

Suicide attempts, age and duration of illness in recurrent affective disorders

1995 • 42 citations

Reboxetine adjunct for partial or nonresponders to antidepressant treatment

2003 • 39 citations

The Maudsley 2003 Prescribing Guidelines

2003 • 39 citations

Using treatment algorithms for the effective management of treatment-resistant depression.

2001 • 38 citations

A 3-year follow-up of a group of treatment-resistant depressed patients with a MAOI/tricyclic combination

1995 • 36 citations

Difficult-to-treat depression: the role of contexts and comorbidities

2003 • 36 citations

Safety and tolerability of combined treatment with moclobemide and SSRIs

1996 • 35 citations

Clomipramine augmentation in treatment-resistant depression

1997 • 33 citations

Do Depressed Subjects Who Have Failed Both Fluoxetine and a Tricyclic Antidepressant Respond to the Combination?

1999 • 32 citations

Treatment-resistant depression: new therapies on the horizon.

2003 • 31 citations

Treatment-Resistant Depression: New Therapies on the Horizon

2003 • 27 citations

What to do if an initial antidepressant fails?

2003 • 23 citations

Effect of Medical Comorbidity on Response to Fluoxetine Augmentation or Dose Increase in Outpatients With Treatment-Resistant Depression

2004 • 23 citations

Moclobemide and specific serotonin re‐uptake inhibitor combination treatment of resistant anxiety and depressive disorders

1995 • 22 citations

Combination Therapy Using Moclobemide with Tricyclic and Tetracyclic Antidepressants to Treat Therapy-resistant Depression

1997 • 21 citations

Effect of reboxetine augmentation in SSRI resistant patients

2000 • 19 citations

Combined treatment with venlafaxine and tricyclic antidepressants in depressed patients who had partial response to clomipramine or imipramine: initial findings.

2000 • 17 citations

Pathological laughter and obsessive-compulsive disorder in patients with affective illnesses.

2000 • 16 citations

Coadministration therapy with reboxetine and serotonin specific reuptake inhibitors in twenty-four patients with major depression

2000 • 13 citations

[Combination therapy with reboxetine for major depression patients who are partial or nonresponders to serotonin selective reuptake inhibitors].

2003 • 11 citations

Pharmacotherapeutic approaches to treatment-resistant depression.

2003 • 1 citations