Different receptors binding to distinct interfaces on herpes simplex virus gD can trigger events leading to cell fusion and viral entry

The Protein Data Bank

2000 • 35,287 citations

Herpes Simplex Virus-1 Entry into Cells Mediated by a Novel Member of the TNF/NGF Receptor Family

1996 • 1,068 citations

Entry of Alphaherpesviruses Mediated by Poliovirus Receptor-Related Protein 1 and Poliovirus Receptor

1998 • 905 citations

Herpesvirus Entry: an Update

2003 • 570 citations

Three Classes of Cell Surface Receptors for Alphaherpesvirus Entry

2000 • 510 citations

Herpesviruses and heparan sulfate: an intimate relationship in aid of viral entry

2001 • 501 citations

A Cell Surface Protein with Herpesvirus Entry Activity (HveB) Confers Susceptibility to Infection by Mutants of Herpes Simplex Virus Type 1, Herpes Simplex Virus Type 2, and Pseudorabies Virus

1998 • 497 citations

Herpesviruses and heparan sulfate: an intimate relationship in aid of viral entry

2001 • 429 citations

The Many Mechanisms of Viral Membrane Fusion Proteins

2004 • 384 citations

Herpes Simplex Virus Glycoprotein D Bound to the Human Receptor HveA

2001 • 381 citations

Article

2000 • 321 citations

Aujeszky's disease (pseudorabies) virus: the virus and molecular pathogenesis - State of the art, June 1999

2000 • 274 citations

An Analysis of the Biological Properties of Monoclonal Antibodies against Glycoprotein D of Herpes Simplex Virus and Identification of Amino Acid Substitutions that Confer Resistance to Neutralization

1986 • 182 citations

The soluble ectodomain of herpes simplex virus gD contains a membrane-proximal pro-fusion domain and suffices to mediate virus entry

2004 • 149 citations

Nectin2α (PRR2α or HveB) and Nectin2δ Are Low-Efficiency Mediators for Entry of Herpes Simplex Virus Mutants Carrying the Leu25Pro Substitution in Glycoprotein D

2000 • 136 citations

Mutations in the N Termini of Herpes Simplex Virus Type 1 and 2 gDs Alter Functional Interactions with the Entry/Fusion Receptors HVEM, Nectin-2, and 3- O -Sulfated Heparan Sulfate but Not with Nectin-1

2003 • 122 citations

Structure-Based Mutagenesis of Herpes Simplex Virus Glycoprotein D Defines Three Critical Regions at the gD-HveA/HVEM Binding Interface

2003 • 119 citations

The pro-fusion domain of herpes simplex virus glycoprotein D (gD) interacts with the gD N terminus and is displaced by soluble forms of viral receptors

2005 • 94 citations

Mutations in herpes simplex virus glycoprotein D that prevent cell entry via nectins and alter cell tropism

2004 • 92 citations

Single Amino Acid Substitutions in gD of Herpes Simplex Virus I Confer Resistance to gD-Mediated Interference and Cause Cell-Type-Dependent Alterations in Infectivity

1994 • 92 citations

The Major Neutralizing Antigenic Site on Herpes Simplex Virus Glycoprotein D Overlaps a Receptor-Binding Domain

1999 • 89 citations

Identification of functional regions of herpes simplex virus glycoprotein gD by using linker-insertion mutagenesis

1994 • 85 citations

Potential Nectin-1 Binding Site on Herpes Simplex Virus Glycoprotein D

2004 • 84 citations

Striking Similarity of Murine Nectin-1α to Human Nectin-1α (HveC) in Sequence and Activity as a Glycoprotein D Receptor for Alphaherpesvirus Entry

2000 • 83 citations

Porcine HveC, a Member of the Highly Conserved HveC/Nectin 1 Family, Is a Functional Alphaherpesvirus Receptor

2001 • 79 citations

Roles of nectins in cell adhesion, migration and polarization

2004 • 75 citations

Fusion activity of lipid-anchored envelope glycoproteins of herpes simplex virus type 1

2004 • 43 citations

Use of herpes simplex virus and pseudorabies virus chimeric glycoprotein D molecules to identify regions critical for membrane fusion

2004 • 43 citations

Random mutagenesis of the gene encoding a viral ligand for multiple cell entry receptors to obtain viral mutants altered for receptor usage

2004 • 40 citations

Mapping of herpes simplex virus 1 genes with mutations which overcome host restrictions to infection.

1994 • 39 citations

Differences in the N Termini of Herpes Simplex Virus Type 1 and 2 gDs That Influence Functional Interactions with the Human Entry Receptor Nectin-2 and an Entry Receptor Expressed in Chinese Hamster Ovary Cells

2003 • 33 citations

A New Class of Receptor for Herpes Simplex Virus Has Heptad Repeat Motifs That Are Common to Membrane Fusion Proteins

2005 • 31 citations