DNA fragmentation and cytotoxicity from increased cellular deoxyuridylate

Reduction of Ribonucleotides

1979 • 1,170 citations

DNA Repair in Bacteria and Mammalian Cells

1979 • 854 citations

Enzymatic Synthesis of Deoxyribonucleic Acid

1969 • 543 citations

STUDIES ON UNBALANCED GROWTH IN ESCHERICHIA COLI

1954 • 406 citations

Methotrexate-induced misincorporation of uracil into DNA

1980 • 276 citations

A rapid and sensitive high pressure liquid chromatography assay for deoxyribonucleoside triphosphates in cell extracts

1979 • 272 citations

Transient accumulation of Okazaki fragments as a result of uracil incorporation into nascent DNA.

1977 • 265 citations

A rapid quantitative determination of deoxyribonucleoside triphosphates based on the enzymatic synthesis of DNA

1969 • 157 citations

Uracil incorporation: A source of pulse-labeled DNA fragments in the replication of the Escherichia coli chromosome

1978 • 151 citations

An Enzymatic Method for the Determination of dCTP and dGTP in Picomole Amounts

1970 • 140 citations

Accumulation of DNA strand breaks and methotrexate cytotoxicity.

1984 • 136 citations

Selective expansion of mitochondrial nucleoside triphosphate pools in antimetabolite-treated HeLa cells.

1982 • 132 citations

The effect of methotrexate on levels of dUTP in animal cells.

1980 • 128 citations

Synthesis and metabolism of uracil-containing deoxyribonucleic acid in Escherichia coli

1981 • 107 citations

Escherichia coli mutants deficient in deoxyuridine triphosphatase

1978 • 103 citations

Genetic and biochemical consequences of thymidylate stress

1982 • 101 citations

Antifolate-induced misincorporation of deoxyuridine monophosphate into DNA: inhibition of high molecular weight DNA synthesis in human lymphoblastoid cells.

1981 • 94 citations

The prevention of methotrexate toxicity by thymidine infusions in humans.

1977 • 91 citations

Accumulation of DNA strand breaks during thymineless death in thymidylate synthase-negative mutants of mouse FM3A cells.

1983 • 90 citations

Nucleotide levels and incorporation of 5-fluorouracil and uracil into DNA of cells treated with 5-fluorodeoxyuridine.

1982 • 86 citations

Asymmetric Okazaki piece synthesis during replication of simian virus 40 DNA in vivo

1977 • 74 citations

The incorporation of uracil into animal cell DNA in vitro

1978 • 71 citations

Fragile Sites in Chromosomes: Possible Model for the Study of Spontaneous Chromosome Breakage

1983 • 70 citations

Effects of 5-fluoro-2'-deoxyuridine on DNA metabolism in HeLa cells.

1983 • 63 citations

Studies on 1-?-D-arabinofuranosyl cytosine-resistant mutants of Chinese hamster fibroblasts: III. Joint resistance to arabinofuranosyl cytosine and to excess thymidine?A semidominant manifestation of deoxycytidine triphosphate pool expansion

1979 • 50 citations

Inhibition in the Joining of DNA Intermediates to Growing Simian Virus 40 Chains

1973 • 41 citations

Purine modulation of methotrexate cytotoxicity in mammalian cell lines.

1982 • 28 citations

Deoxyuridine triphosphatase: A potential site of interaction with pyrimidine nucleotide analogues

1982 • 20 citations

Effect of methotrexate and 1-beta-D-arabinofuranosylcytosine on pools of deoxyribonucleoside triphosphates in L1210 ascites cells.

1981 • 12 citations

An enzymatic method for distinguishing deoxyuridine and deoxythymidine nucleotide pools and its application for determining ribonucleotide reductase activity

1979 • 10 citations