Hypoxia-Selective Agents Derived from Quinoxaline 1,4-Di-N-oxides

The Histological Structure of Some Human Lung Cancers and the Possible Implications for Radiotherapy

1955 • 2,174 citations

Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy

1988 • 811 citations

Bioactivation as a Model for Drug Design Bioreductive Alkylation

1977 • 432 citations

Definitive evidence for hypoxic cells influencing cure in cancer therapy.

1978 • 422 citations

SR 4233 (Tirapazamine): a new anticancer drug exploiting hypoxia in solid tumours

1993 • 354 citations

The hypoxic tumor cell: A target for selective cancer chemotherapy

1980 • 291 citations

Primary radiotherapy of larynx and pharynx carcinoma—An analysis of some factors influencing local control and survival

1986 • 241 citations

Resistance to adriamycin in multicellular spheroids

1979 • 227 citations

Increased cell killing by metronidazole and nitrofurazone of hypoxic compared to aerobic mammalian cells.

1976 • 183 citations

Response of Chinese hamster ovary cells to anticancer drugs under aerobic and hypoxic conditions

1981 • 110 citations

RSU 1069, a nitroimidazole containing an aziridine group

1986 • 104 citations

Hypoxic cells as specific drug targets for chemotherapy.

1987 • 87 citations

Evaluation of bioreductive drugs in multicell spheroids

1992 • 53 citations

Cyclic voltammetry of phenazines and quinoxalines including mono- and di-N-oxides. Relation to structure and antimicrobial activity

1986 • 49 citations

Phase I clinical and pharmacological study of chloroquinoxaline sulfonamide.

1992 • 31 citations

Cytogenetic effects of quinoxaline-1,4-dioxide-type growth-promoting agents III. Transplacental micronucleus test in mice

1985 • 31 citations

Reaction of benzofurazan oxide with unsymmetrical 1,3-diketones; steric and polar effects

1976 • 19 citations

Redox Activation of Benzotriazine N-Oxides: Mechanisms and Potential as Anticancer Drugs

1990 • 9 citations