(Diisopropylphosphoryl)serine proteinases. Proton and phosphorus-31 nuclear magnetic resonance-pH titration studies

Serine Proteases: Structure and Mechanism of Catalysis

1977 • 1,238 citations

p-Nitrophenyl-p′-guanidinobenzoate HCl: A new active site titrant for trypsin

1967 • 848 citations

Location of disulphide bridges by diagonal paper electrophoresis. The disulphide bridges of bovine chymotrypsinogen A.

1966 • 450 citations

Subtilisin. Stereochemical mechanism involving transition-state stabilization

1972 • 376 citations

Chymotrypsinogen: 2,5-Å crystal structure, comparison with α-chymotrypsin, and implications for zymogen activation

1970 • 345 citations

The structure of bovine trypsin : Electron density maps of the inhibited enzyme at 5 Å and at 2·7 Å resolution

1974 • 279 citations

Crystal structure of bovine trypsinogen at 1·8 Å resolution

1977 • 242 citations

Carbon nuclear magnetic resonance studies of the histidine residue in α-lytic protease. Implications for the catalytic mechanism of serine proteases

1973 • 239 citations

INHIBITION OF THE PROTEINASE AND ESTERASE ACTIVITIES OF TRYPSIN AND CHYMOTRYPSIN BY DIISOPROPYL FLUOROPHOSPHATE: CRYSTALLIZATION OF INHIBITED CHYMOTRYPSIN

1949 • 237 citations

[5] Chymotrypsinogens—chymotrypsins

1970 • 206 citations

Pulse methods for the simplification of protein NMR spectra

1975 • 191 citations

Structure of bovine trypsinogen at 1.9 Å resolution

1977 • 174 citations

SERINE PHOSPHORIC ACID FROM DIISOPROPYLPHOSPHORYL CHYMOTRYPSIN

1953 • 159 citations

The chemical basis of the “ageing process” of DFP-inhibited pseudocholinesterase

1959 • 150 citations

The kinetics of reactivation, by oximes, of cholinesterase inhibited by organophosphorus compounds

1956 • 124 citations

MODE OF INHIBITION OF CHYMOTRYPSIN BY DIISOPROPYL FLUOROPHOSPHATE

1949 • 120 citations

A generalized gauche NMR effect in carbon-13, fluorine-19, and phosphorus-31 chemical shifts and directly bonded coupling constants. Torsional angle and bond angle effects

1977 • 102 citations

Crystal structure of bovine trypsinogen at 1.8 Å resolution. I. Data collection, application of Patterson search techniques and preliminary structural interpretation

1976 • 98 citations

The mechanism of reaction between esterases and phosphorus-containing anti-esterases

1955 • 93 citations

The Autoactivation of Trypsinogen

1971 • 92 citations

Sur le trypsinogène et la trypsine de porc

1963 • 86 citations

Catalysis by chymotrypsinogen. Demonstration of an acyl-zymogen intermediate

1974 • 85 citations

Zymogen activation in serine proteinases. Proton magnetic resonance pH titration studies of the two histidines of bovine chymotrypsinogen A and chymotrypsin A.alpha.

1978 • 79 citations

Kernmagnetische Resonanzspektroskopie des Phosphors

1962 • 74 citations

Inactivation of Bovine Trypsinogen and Chymotrypsinogen by Diisopropylphosphorofluoridate

1972 • 73 citations

The charge-relay system of serine proteinases: Proton magnetic resonance titration studies of the four histidines of porcine trypsin

1976 • 69 citations

The study of α-chymotrypsin by x-ray diffraction. The Third CIBA Medal Lecture

1969 • 68 citations

Relation of the α-amino group of trypsin to enzyme function and zymogen activation

1973 • 64 citations

REACTIVATION OF DIETHYL p-NITROPHENYL PHOSPHATE-INHIBITED α-CHYMOTRYPSIN BY HYDROXYLAMINE

1954 • 57 citations

Studies on the Reactivation of Diethylphosphorylchymotrypsin¹

1960 • 55 citations

Coherent broad-band decoupling—An alternative to proton noise decoupling in carbon-13 nuclear magnetic resonance spectroscopy

1975 • 51 citations

The nature of the reaction between diisopropylfluorophosphate and chymotrypsin

1955 • 49 citations

Kinetics of the Reaction of α-Chymotrypsin with Diisopropyl Fluorophosphate, with Measurements of Hydrogen Ion Release, Enzyme Inhibition, and Spectral Changes of Enzyme at 290 mµ

1965 • 40 citations

The chemical structure of the reactive group of esterases

1955 • 37 citations

CONCERNING THE NATURE OF THE α- AND β-LYTIC PROTEASES OF SORANGIUM SP.

1967 • 30 citations

Phosphate and carbonate ester aging reactions with .alpha.-chymotrypsin. Kinetics and mechanism

1972 • 27 citations

31P NMR of diisopropyl phosphoryl α-chymotrypsin and catechol cyclic phosphate α-chymotrypsin. Direct observation of two conformational isomers

1976 • 22 citations

Active site in zymogens. Proton magnetic resonance pH titration curves of histidine-57 in porcine and bovine trypsinogens and in their complexes with bovine pancreatic trypsin inhibitor (Kunitz)

1978 • 22 citations

The reactivation of phosphorylated chymotrypsin

1959 • 20 citations

The Time Dependence of the Activity of δ‐Chymotrypsin at High pH

1973 • 17 citations

Comparisons of diisopropylfluorophosphate derivatives of chymotrypsin and chymotrypsinogen by phosphorus-31 nuclear magnetic resonance

1977 • 15 citations

Chymotrypsin-substrate complexes. Hydrogen ion equilibria in chymotrypsin and diisopropylphosphoryl-chymotrypsin

1964 • 14 citations

An ageing effect in inhibited esterases: Elimination of phenol from DPClP-inhibited chymotrypsin and trypsin

1961 • 13 citations

A broadband system for the observation of NMR spectra of any resonant nucleus

1976 • 9 citations

Reactivation of α-chymotrypsin inhibited by organic phosphates

1953 • 8 citations

Liberation of phenol from diphenylphosphoryl chymotrypsin

1958 • 8 citations

Total systematic noise reduction in Fourier transform nuclear magnetic resonance spectrometry

1976 • 3 citations