Interaction of mutant hepatitis B X protein with p53 tumor suppressor protein affects both transcription and cell survival

p53 Mutations in Human Cancers

1991 • 8,133 citations

Requirement for p53 and p21 to Sustain G ₂ Arrest After DNA Damage

1998 • 2,784 citations

Production of hepatitis B virus particles in Hep G2 cells transfected with cloned hepatitis B virus DNA.

1987 • 1,098 citations

Oncogenic BRAF Induces Senescence and Apoptosis through Pathways Mediated by the Secreted Protein IGFBP7

2008 • 846 citations

Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3.

1994 • 666 citations

Associations Between Hepatitis B Virus Genotype and Mutants and the Risk of Hepatocellular Carcinoma

2008 • 567 citations

Effects of a naturally occurring mutation in the hepatitis B virus basal core promoter on precore gene expression and viral replication

1996 • 474 citations

Human DNA-Activated Protein Kinase Phosphorylates Serines 15 and 37 in the Amino-Terminal Transactivation Domain of Human p53

1992 • 473 citations

Hepatocellular Carcinoma: The Need for Progress

2005 • 410 citations

Functional inactivation but not structural mutation of p53 causes liver cancer

1995 • 364 citations

Hepatitis B virus X protein and p53 tumor suppressor interactions in the modulation of apoptosis

1997 • 322 citations

Abrogation of p53-Induced Apoptosis by the Hepatitis B Virus X Gene

2003 • 318 citations

Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53.

1992 • 255 citations

Hepatitis B virus X mutants, present in hepatocellular carcinoma tissue abrogate both the antiproliferative and transactivation effects of HBx

1999 • 205 citations

Transcriptional activation of homologous and heterologous genes by the hepatitis B virus X gene product in cells permissive for viral replication

1989 • 204 citations

X-gene Product of Hepatitis B Virus Induces Apoptosis in Liver Cells

1998 • 194 citations

Intracellular localization of the hepatitis B virus HBx protein

2001 • 164 citations

Mutation of the serine 15 phosphorylation site of human p53 reduces the ability of p53 to inhibit cell cycle progression.

1993 • 140 citations

Transcriptional repression of the human p53 gene by hepatitis B viral X protein

2000 • 119 citations

HBV A₁₇₆₂T, G₁₇₆₄A Mutations Are a Valuable Biomarker for Identifying a Subset of Male HBsAg Carriers at Extremely High Risk of Hepatocellular Carcinoma: A Prospective Study

2008 • 108 citations

Effects of a frequent double-nucleotide basal core promoter mutation and its putative single-nucleotide precursor mutations on hepatitis B virus gene expression and replication.

1997 • 106 citations

Basal core promoter T1762/A1764 and precore A1896 gene mutations in hepatitis B surface antigen‐positive hepatocellular carcinoma: a comparison with chronic carriers

2007 • 97 citations

Regulation of Hepatitis B Virus Core Promoter by Transcription Factors HNF1 and HNF4 and the Viral X Protein

2004 • 94 citations

Activation of Focal Adhesion Kinase by Hepatitis B Virus HBx Protein: Multiple Functions in Viral Replication

2006 • 93 citations

The transactivation and p53-interacting functions of hepatitis B virus X protein are mutually interfering but distinct.

1997 • 87 citations

Cytoplasmic retention of the p53 tumor suppressor gene product is observed in the hepatitis B virus X gene-transfected cells

1997 • 83 citations

The Role of BRAF Mutation and p53 Inactivation during Transformation of a Subpopulation of Primary Human Melanocytes

2009 • 77 citations

Expression of cloned hepatitis B virus DNA in human cell cultures.

1980 • 77 citations

Hepatitis B Virus Promotes Angiopoietin-2 Expression in Liver Tissue

2006 • 72 citations

Prospective Evaluation of Hepatitis B 1762T/1764A Mutations on Hepatocellular Carcinoma Development in Shanghai, China

2009 • 62 citations

The Hepatitis B Virus X Protein Sensitizes HepG2 Cells to UV Light-induced DNA Damage

2005 • 60 citations

Hepatitis B 1762T/1764A Mutations, Hepatitis C Infection, and Codon 249 p53 Mutations in Hepatocellular Carcinomas from Thailand

2005 • 60 citations

Expression of hepatitis B virus X oncoprotein inhibits transcription-coupled nucleotide excision repair in human cells

2004 • 43 citations

Multiple alternate p21 transcripts are regulated by p53 in human cells

2005 • 43 citations

Cooperation of tumor‐derived HBx mutants and p53‐249^ser mutant in regulating cell proliferation, anchorage‐independent growth and aneuploidy in a telomerase‐immortalized normal human hepatocyte‐derived cell line

2009 • 41 citations

COX-2 mediates hepatitis B virus X protein abrogation of p53-induced apoptosis

2008 • 32 citations

HBV transcription repression in response to genotoxic stress is p53-dependent and abrogated by pX

1999 • 27 citations