Arginine-free diet suppresses nitric oxide production in wounds☆

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

Vascular endothelial cells synthesize nitric oxide from L-arginine

1988 • 4,800 citations

Nitric oxide as a secretory product of mammalian cells

1992 • 4,437 citations

Glutamate, nitric oxide and cell-cell signalling in the nervous system

1991 • 2,406 citations

Polyamine metabolism and function

1982 • 1,649 citations

Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate

1988 • 1,622 citations

Mammalian nitrate biosynthesis: mouse macrophages produce nitrite and nitrate in response to Escherichia coli lipopolysaccharide.

1985 • 1,146 citations

Nanogram nitrite and nitrate determination in environmental and biological materials by vanadium(III) reduction with chemiluminescence detection

1989 • 867 citations

Induction of nitrite/nitrate synthesis in murine macrophages by BCG infection, lymphokines, or interferon-gamma.

1987 • 722 citations

Induction of nitric oxide synthase by cytokines in vascular smooth muscle cells

1990 • 700 citations

Activated macrophages destroy intracellular Leishmania major amastigotes by an L-arginine-dependent killing mechanism.

1990 • 690 citations

Microbiostatic effect of murine-activated macrophages for Toxoplasma gondii. Role for synthesis of inorganic nitrogen oxides from L-arginine.

1990 • 573 citations

Nitrate Synthesis in the Germfree and Conventional Rat

1981 • 551 citations

Arginine enhances wound healing and lymphocyte immune responses in humans.

1990 • 446 citations

Immune and Metabolic Effects of Arginine in the Surgical Patient

1988 • 436 citations

Nitric oxide: biosynthesis and biological significance

1989 • 421 citations

Endogenously synthesized nitric oxide prevents endotoxin-induced glomerular thrombosis.

1992 • 324 citations

Epidermal growth factor suppresses nitric oxide and hydrogen peroxide production by keratinocytes. Potential role for nitric oxide in the regulation of wound healing.

1992 • 279 citations

Constitutive nitric oxide synthase from cerebellum is reversibly inhibited by nitric oxide formed from L-arginine

1992 • 254 citations

Arginine: an essential amino acid for injured rats.

1978 • 240 citations

Metabolic and Immune Effects of Dietary Arginine Supplementation After Burn

1987 • 198 citations

Arginine metabolism in wounds

1988 • 196 citations

Calmodulin-independent nitric oxide synthase from rat polymorphonuclear neutrophils

1991 • 195 citations

Macrophage arginine metabolism and the inhibition or stimulation of cancer.

1992 • 192 citations

Nitric oxide synthesis serves to reduce hepatic damage during acute murine endotoxemia

1992 • 172 citations

Urinary nitrate excretion in relation to murine macrophage activation. Influence of dietary L-arginine and oral NG-monomethyl-L-arginine.

1991 • 146 citations

Wound healing and thymotropic effects of arginine: a pituitary mechanism of action

1983 • 137 citations

L-Arginine is a precursor for nitrate biosynthesis in humans

1989 • 133 citations

Intravenous hyperalimentation with high arginine levels improves wound healing and immune function

1985 • 122 citations

Macrophages: Current Views on Their Differentiation, Structure, and Function

1989 • 116 citations

Immune Aspects of Wound Repair

1990 • 112 citations

Improvement of Nitrogen Retention by Arginine and Glycine Supplementation and Its Relation to Collagen Synthesis in Traumatized Mature and Aged Rats

1984 • 92 citations

Stimulation of T cell immunity by arginine enhances survival in peritonitis

1988 • 87 citations

Arginine Supplementation and Its Effect on Established Peritonitis in Guinea Pigs

1990 • 84 citations

Effect of dietary arginine restriction upon ornithine and polyamine metabolism during two-stage epidermal carcinogenesis in the mouse.

1991 • 72 citations

Depletion of Dietary Arginine Inhibits Growth of Metastatic Tumor

1991 • 71 citations

Macrophage-derived Growth Factors in Wound Healing: Regulation of Growth Factor Production by the Oxygen Microenvironment

1989 • 46 citations

Evidence that activation of Kupffer cells results in production of L-arginine metabolites that release cell-associated iron and inhibit hepatocyte protein synthesis.

1989 • 41 citations

Arginine Supplementation Improves Histone and Acute‐Phase Protein Synthesis During Gram‐Negative Sepsis in the Rat

1991 • 31 citations

Arginine-Deficient Diets Alter Plasma and Tissue Amino Acids in Young and Aged Rats

1991 • 26 citations

Animal models of wound contraction.

1991 • 26 citations

Enhancement of Interleukin-2 Immunotherapy with L-Arginine

1992 • 23 citations

Mediation of post-surgical wound healing by macrophages.

1988 • 12 citations

Alteration of Physiological Activity of Activated Macrophages through L‐Arginine Metabolism

1991 • 9 citations

Concomitant macrophage activation and fibroblast/lymphocyte inhibition by wound fluid: the "arginine-deficiency of inflammation" is a partial explanation.

1991 • 3 citations