Degradation of Endogenous and Exogenous Gastric Inhibitory Polypeptide in Healthy and in Type 2 Diabetic Subjects as Revealed Using a New Assay for the Intact Peptide1

Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus.

1993 • 1,579 citations

Dipeptidyl‐peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon‐like peptide‐1(7–36)amide, peptide histidine methionine and is responsible for their degradation in human serum

1993 • 1,119 citations

Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV.

1995 • 1,064 citations

Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo.

1995 • 741 citations

Both subcutaneously and intravenously administered glucagon-like peptide I are rapidly degraded from the NH2-terminus in type II diabetic patients and in healthy subjects

1995 • 705 citations

Additive insulinotropic effects of exogenous synthetic human gastric inhibitory polypeptide and glucagon-like peptide-1-(7-36) amide infused at near-physiological insulinotropic hormone and glucose concentrations.

1993 • 467 citations

The insulinotropic actions of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (7–37) in normal and diabetic subjects

1994 • 309 citations

Glucagon-like peptide 1 undergoes differential tissue-specific metabolism in the anesthetized pig

1996 • 291 citations

Dipeptidyl peptidase IV resistant analogues of glucagon-like peptide-1 which have extended metabolic stability and improved biological activity

1998 • 279 citations

New developments in the incretin concept

1985 • 275 citations

Structure-activity studies of glucagon-like peptide-1.

1994 • 272 citations

Secretion of the Incretin Hormones Glucagon-Like Peptide-1 and Gastric Inhibitory Polypeptide Correlates with Insulin Secretion in Normal Man Throughout the Day

1996 • 255 citations

Characterisation of the processing by human neutral endopeptidase 24.11 of GLP-1(7–36) amide and comparison of the substrate specificity of the enzyme for other glucagon-like peptides

1995 • 221 citations

Inhibition of dipeptidyl peptidase IV with NVP-DPP728 increases plasma GLP-1 (7-36 amide) concentrations and improves oral glucose tolerance in obese Zucker rats

1999 • 212 citations

Pancreatic and intestinal processing of proglucagon in man

1987 • 203 citations

Amino acid sequence and heterogeneity of gastric inhibitory polypeptide (GIP)

1981 • 164 citations

Diminished Immunoreactive Gastric Inhibitory Polypeptide Response to a Meal in Newly Diagnosed Type I (Insulin-Dependent) Diabetics*

1983 • 156 citations

Investigation of Glucose-dependent Insulinotropic Polypeptide(1-42) and Glucagon-like Peptide-1-(7-36) Degradation by Dipeptidyl Peptidase IV Using Matrix-assisted Laser Desorption/Ionization-Time of Flight Mass Spectrometry

1996 • 153 citations

The heterogeneity of gastric inhibitory polypeptide in porcine and human gastrointestinal mucosa evaluated with five different antisera

1984 • 110 citations

Glucagon-Like Peptide-I Analogs: Effects on Insulin Secretion and Adenosine 3′,5′-Monophosphate Formation*

1990 • 106 citations

Insulinotropic Properties of Synthetic Human Gastric Inhibitory Polypeptide in Man: Interactions with Glucose, Phenylalanine, and Cholecystokinin-8

1989 • 103 citations

Current concepts of renal hemodynamics in diabetes

1995 • 74 citations

Glomerular hyperfiltration in microalbuminuric NIDDM patients

1996 • 67 citations

Responses and molecular heterogeneity of IR-GIP after intraduodenal glucose and fat

1985 • 56 citations

Chronic renal failure: Effect of hemodialysis on gastrointestinal hormones

1984 • 55 citations

The enteroinsular axis in dipeptidyl peptidase IV-negative rats

1996 • 52 citations

Actions of GIP

1981 • 45 citations

Renal effects on serum gastric inhibitory polypeptide (GIP)

1977 • 39 citations

The Hepatic Extraction of Gastric Inhibitory Polypeptide and Insulin*

1984 • 34 citations

Glomerular filtration rate and kidney size in type 2 (non-insulin-dependent) diabetes mellitus.

1995 • 23 citations

The pharmacokinetics of porcine glucose‐dependent insulinotropic polypeptide (GIP) in man

1982 • 14 citations

Removal of IR-GIP by the Kidneys in Man, and the Effect of Acute Nephrectomy on Plasma GIP in Rats

1981 • 12 citations

Absence of hepatic extraction of gastric inhibitory polypeptide in conscious dogs

1987 • 10 citations

Synthetic peptides as antigen

1986 • 6 citations

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