The role of imidazoline receptors in blood pressure regulation

The Effects of Antihypertensive Therapy on the Quality of Life

1986 • 1,344 citations

Central cardiovascular effects of alpha adrenergic drugs: differences between catecholamines and imidazolines.

1984 • 508 citations

Clonidine binds to imidazole binding sites as well as α2-adrenoceptors in the ventrolateral medulla

1987 • 444 citations

The alpha-2 adrenergic agonist guanfacine improves memory in aged monkeys without sedative or hypotensive side effects: evidence for alpha-2 receptor subtypes

1988 • 386 citations

Role of imidazole receptors in the vasodepressor response to clonidine analogs in the rostral ventrolateral medulla.

1990 • 322 citations

.alpha.2 Adrenoceptors: classification, localization, mechanisms and targets for drugs

1982 • 290 citations

Are there multiple imidazoline binding sites?

1989 • 250 citations

Characterization of α-adrenoceptors participating in the central hypotensive and sedative effects of clonidine using yohimbine, rauwolscine and corynanthine

1981 • 215 citations

Anatomical evidence for alpha-2 adrenoceptor heterogeneity: differential autoradiographic distributions of [3H]rauwolscine and [3H]idazoxan in rat brain.

1987 • 185 citations

[3H]idazoxan and some other alpha 2-adrenergic drugs also bind with high affinity to a nonadrenergic site.

1989 • 174 citations

The imidazoline preferring receptor: binding studies in bovine, rat and human brainstem

1989 • 167 citations

Comparison of the ?-adrenoceptor antagonist profiles of idazoxan (RX 781094), yohimbine, rauwolscine and corynanthine

1984 • 161 citations

Subcellular distribution of imidazoline-guanidinium-receptive sites in human and rabbit liver. Major localization to the mitochondrial outer membrane.

1991 • 156 citations

Isolation and partial purification of a clonidine‐displacing endogenous brain substance

1984 • 148 citations

An endogenous clonidine-displacing substance from bovine brain: receptor binding and hypotensive actions in the ventrolateral medulla

1986 • 140 citations

Pharmacological evidence for alpha-2 adrenoceptor heterogeneity: differential binding properties of [3H]rauwolscine and [3H]idazoxan in rat brain.

1987 • 139 citations

Characterization of an imidazoline/guanidinium receptive site distinct from the α2-adrenergic receptor

1989 • 119 citations

Evidence for imidazoline binding sites in basolateral membranes from rabbit kidney

1987 • 118 citations

An insulin-releasing property of imidazoline derivatives is not limited to compounds that block ?-adrenoceptors

1989 • 118 citations

α₂‐Adrenoceptor subtypes and imidazoline‐like binding sites in the rat brain

1990 • 114 citations

? 2-Adrenoceptors modulating insulin release from isolated pancreatic islets

1980 • 114 citations

An endogenous substance with clonidine-like properties: selective binding to imidazole sites in the ventrolateral medulla

1988 • 113 citations

[3H]Idazoxan binding at non-α2-adrenoceptors in rabbit adipocyte membranes

1989 • 109 citations

Further Characterization of the Guinea Pig Cerebral Cortex Idazoxan Receptor: Solubilization, Distinction from the Imidazole Site, and Demonstration of Cirazoline as an Idazoxan Receptor‐Selective Drug

1990 • 103 citations

Binding of [3H]p-aminoclonidine to two sites, α2-adrenoceptors and imidazoline binding sites: distribution of imidazoline binding sites in rat brain

1990 • 102 citations

Reduction in Focal Cerebral Ischemia by Agents Acting at Imidazole Receptors

1992 • 101 citations

Involvement of presynaptic imidazoline receptors in the ?2-adrenoceptor-independent inhibition of noradrenaline release by imidazoline derivatives

1991 • 100 citations

Lack of cross-desensitization between structurally dissimilar α-adrenoceptor agonists

1977 • 97 citations

Alpha 2 adrenergic agonists stimulate Na+-H+ antiport activity in the rabbit renal proximal tubule.

1987 • 96 citations

[3H]yohimbine and [3H]idazoxan bind to different sites on rabbit forebrain and kidney membranes

1988 • 94 citations

Effects of clonidine and BS 100–141 on the EEG sleep pattern in rats

1975 • 94 citations

Imidazoline receptors in rat liver cells: A novel receptor or a subtype of α2-adrenoceptors?

1990 • 92 citations

Imidazoline-guanidinium receptive site in renal proximal tubule: asymmetric distribution, regulation by cations and interaction with an endogenous clonidine displacing substance.

1990 • 91 citations

Postischemic Administration of Idazoxan, an α-2 Adrenergic Receptor Antagonist, Decreases Neuronal Damage in the Rat Brain

1989 • 91 citations

An endogenous, non-catecholamine clonidine antagonist increases mean arterial blood pressure

1986 • 83 citations

Medetomidine stereoisomers delineate two closely related subtypes of idazoxan (imidazoline) I-receptors in the guinea pig

1991 • 82 citations

The hypotensive activity and side effects of methyldopa, clonidine, and guanfacine.

1984 • 81 citations

Clonidine-displacing substance (CDS) and its putative imidazoline receptor

1991 • 74 citations

Effect of imidazolines on Na+ transport and intracellular pH in renal proximal tubule cells

1990 • 70 citations

Nonadrenergic [3H]idazoxan binding sites are physically distinct from alpha 2-adrenergic receptors.

1990 • 70 citations

Evidence for the existence of a homogenous population of imidazoline receptors in the human brainstem

1988 • 67 citations

Isolation of an endogenous clonidine‐displacing substance from rat brain

1984 • 66 citations

A multicenter double-blind comparative study of rilmenidine and clonidine in 333 hypertensive patients

1988 • 64 citations

Differences in the applicability of the Easson-Stedman hypothesis to the α1- and α2-adrenergic effects of phenethylamines and imidazolines

1983 • 64 citations

Imidazoline-guanidinium and α2-adrenergic binding sites in basolateral membranes from human kidney

1991 • 61 citations

High Affinity Binding of Idazoxan to a Non‐Catecholaminergic Binding Site in the Central Nervous System: Description of a Putative Idazoxan‐Receptor

1989 • 55 citations

Clonidine displacing substance is biologically active on smooth muscle

1987 • 54 citations

Guanabenz, guanochlor, guanoxan and idazoxan bind with high affinity to non-adrenergic sites in pig kidney membranes

1989 • 53 citations

Effect of alpha2 agonists clonidine, guanfacine and B-HT 920 on gastric acid secretion and ulcers in rats.

1985 • 50 citations

An endogenous brain substance, CDS (clonidine-displacing-substance), inhibits the twitch response of rat vas deferens

1986 • 48 citations

Evidence for non-adrenergic binding sites for [3H]idazoxan in the smooth muscle of rabbit urethra

1988 • 46 citations

Cardiovascular and central nervous system effects of rilmenidine (S 3341) in rats

1988 • 46 citations

A low molecular weight brain substance interacts, similarly to clonidine, with α2-adrenoceptors of human platelets

1987 • 44 citations

Effects of α‐adrenoceptor antagonists on clonidine‐induced inhibition of insulin secretion by isolated pancreatic islets

1983 • 44 citations

Imidazole binding sites in rabbit kidney and forebrain membranes

1991 • 40 citations

Protective effect of a novel imidazole derivative against cerebral anoxia.

1978 • 27 citations

Effects of 4-chloro-2-(2-imidazolin-2-ylamino)-isoindoline Hydrochloride (BE 6143) at pre- and postsynaptic alpha-adrenoceptors in rabbit aorta and pulmonary artery.

1982 • 26 citations

Gastric Lesion-Preventing or -Potentiating Activity of Clonidine in Rats

1986 • 23 citations

Rilmenidine (S 3341) and the sympathoadrenal system: adrenoreceptors, plasma and adrenal catecholamines in dogs

1988 • 21 citations

Clonidine-Displacing Substance is Present in Peripheral Tissues of the Rat

1989 • 21 citations

Amiloride interacts with [3H]idazoxan and [3H]rauwolscine binding sites in rabbit urethra

1989 • 20 citations

Effects of continuous infusions (10 days) and cessation of infusions of clonidine and rilmenidine (S 3341) on cardiovascular and behavioral parameters of spontaneously hypertensive rats

1988 • 20 citations

Dual action of clonidine on ethanol-induced gastric lesions: is the imidazoline-preferring receptor involved?

1991 • 19 citations

Prolactin (PRL) release-inhibiting properties of the α2 adrenergic receptor antagonist Idazoxan: Comparison with yohimbine

1989 • 18 citations

CARDIOVASCULAR EFFECTS OF RILMENIDINE, A NEW α₂‐ADRENOCEPTOR AGONIST, AND CLONIDINE IN CONSCIOUS SPONTANEOUSLY HYPERTENSIVE RATS

1989 • 18 citations

Differences in the regulation of [3H]idazoxan and [3H]yohimbine binding sites in the rabbit

1990 • 16 citations

The paradox of α2 adrenergic regulation of prolactin (PRL) secretion. I. the PRL-releasing action of the α2 receptor agonists

1989 • 14 citations

Central Cardiovascular Effects of a Noncatecholamine Endogenous Ligand for Clonidine Receptors

1987 • 13 citations

Adrenergic and Nonadrenergic Effects of Imidazoline and Related Antihypertensive Drugs in the Brain and Periphery

1992 • 10 citations

The paradox of α2 adrenergic regulation of prolactin (PRL) secretion. II. PRL-releasing action of the α2 receptor antagonists

1989 • 9 citations

Proximal Tubular α2-Adrenoceptor Density in the Spontaneously Hypertensive Rat

1991 • 9 citations

Differential cardiovascular effects of central clonidine and B-HT 920 in conscious rats

1988 • 9 citations

Desensitization and down‐regulation of brain alpha 2‐adrenoceptors by centrally acting antihypertensive drugs.

1990 • 8 citations

α‐ADRENOCEPTOR PROPERTIES IN RAT STRAINS SENSITIVE OR RESISTANT TO SALT‐INDUCED HYPERTENSION

1989 • 8 citations

Rapid Eye Movement Sleep and the Associated Cardiovascular Changes During and After Continuous 10-Day Infusion of Clonidine in Normotensive Rats

1987 • 7 citations