Sex hormone-binding globulin, its membrane receptor, and breast cancer: a new approach to the modulation of estradiol action in neoplastic cells

Estrogen action via the cAMP signaling pathway: stimulation of adenylate cyclase and cAMP-regulated gene transcription.

1994 • 667 citations

A Prospective Study of Endogenous Estrogens and Breast Cancer in Postmenopausal Women

1995 • 635 citations

A prospective study of endogenous serum hormone concentrations and breast cancer risk in post-menopausal women on the island of Guernsey

1997 • 295 citations

Serum concentrations of total and non‐protein‐bound oestradiol in patients with breast cancer and in normal controls

1982 • 179 citations

Testosterone-estradiol-binding globulin binds to human prostatic cell membranes

1985 • 146 citations

A recognition system for sex-hormone-binding protein-estradiol complex in human decidual endometrium plasma membranes

1984 • 143 citations

Estradiol causes the rapid accumulation of cAMP in human prostate.

1994 • 136 citations

Biologically Active Steroids Activate Receptor-Bound Human Sex Hormone-Binding Globulin to Cause LNCaP Cells to Accumulate Adenosine 3′,5′-Monophosphate*

1990 • 129 citations

Sex steroid binding protein exerts a negative control on estradiol action in MCF-7 cells (human breast cancer) through cyclic adenosine 3',5'-monophosphate and protein kinase A

1996 • 123 citations

Immunocytochemical localization of the sex steroid-binding protein of plasma in tissues of the adult monkey Macaca nemestrina.

1980 • 120 citations

Differential effects of oral conjugated estrogens and transdermal estradiol on insulin-like growth factor 1, growth hormone and sex hormone binding globulin serum levels

1993 • 116 citations

Serum Steroid Hormone Levels, Sex Hormone-Binding Globulin, and Body Mass Index in the Etiology of Postmenopausal Breast Cancer

1996 • 98 citations

Estradiol Activates the Prostate Androgen Receptor and Prostate-specific Antigen Secretion through the Intermediacy of Sex Hormone-binding Globulin

1997 • 93 citations

Sex steroid binding protein exerts a negative control on estradiol action in MCF-7 cells (human breast cancer) through cyclic adenosine 3',5'-monophosphate and protein kinase A.

1996 • 77 citations

Human Variant Sex Hormone-Binding Globulin (SHBG) with an Additional Carbohydrate Chain Has a Reduced Clearance Rate in Rabbit¹

1998 • 72 citations

Non-protein bound oestradiol, sex hormone binding globulin, breast cancer and breast cancer risk

1985 • 68 citations

The receptor-mediated action of sex steroid binding protein (SBP, SHBG): Accumulation of cAMP in MCF-7 cells under SBP and estradiol treatment

1994 • 68 citations

Molecular analyses of a human sex hormone-binding globulin variant: evidence for an additional carbohydrate chain.

1992 • 56 citations

Human Variant Sex Hormone-Binding Globulin (SHBG) with an Additional Carbohydrate Chain Has a Reduced Clearance Rate in Rabbit

1998 • 53 citations

Serum Concentrations of Estrone, Androstenedione, Testosterone and Sex-hormone-binding Globulin in Postmenopausal Women with Breast Cancer and in Age-matched Controls

1979 • 51 citations

Biological relevance of the interaction between sex steroid binding protein and its specific receptor of MCF-7 cells: Effect on the estradiol-induced cell proliferation

1993 • 50 citations

Binding of an extracellular steroid-binding globulin to membranes and soluble receptors from human breast cancer cells (MCF-7 cells).

1992 • 49 citations

Endogenous estrogens and risk of breast cancer by estrogen receptor status: a prospective study in postmenopausal women.

1995 • 48 citations

Decrease of circulating level of SHBG in postmenopausal obese women as a risk factor in breast cancer: Reversible effect of weight loss

1986 • 48 citations

Immunohistochemical Localization of Sex Hormone-Binding Globulin in Normal and Neoplastic Breast Tissue

1990 • 45 citations

Estradiol induction of cAMP in breast cancer cells is mediated by foetal calf serum (FCS) and sex hormone-binding globulin (SHBG)

1999 • 40 citations

Bioavailability of estradiol as a marker for breast cancer risk assessment.

1987 • 40 citations

Androgenic progestogens oppose the decrease of insulin-like growth factor I serum level induced by conjugated oestrogens in postmenopausal women. Preliminary report

1994 • 36 citations

The additionally glycosylated variant of human sex hormone‐binding globulin (SHBG) is linked to estrogen‐dependence of breast cancer

1999 • 34 citations

Molecular analyses of a human sex hormone-binding globulin variant: evidence for an additional carbohydrate chain

1992 • 34 citations

Expression and Differential Glycosylation of Human Sex Hormone-Binding Globulin by Mammalian Cell Lines

1991 • 32 citations

Binding of an extracellular steroid-binding globulin to membranes and soluble receptors from human breast cancer cells (MCF-7 cells)

1992 • 29 citations

Sex hormone binding globulin mRNA in human breast cancer: Detection in cell lines and tumor samples

1996 • 28 citations

Post-menopausal breast cancer risk: oral estrogen treatment and abdominal obesity induce opposite changes in possibly important biological variables.

1992 • 28 citations

Sex Hormone Binding Globulin as a Reliable Indicator of Hormone Dependence in Human Breast Cancer

1979 • 27 citations

Sex steroid binding protein receptor (SBP-R) is related to a reduced proliferation rate in human breast cancer

1997 • 26 citations

Sex Hormone-Binding Globulin and Estrogen Receptor in Breast Cancer: Technique and Preliminary Clinical Results*

1978 • 26 citations

Regulation of SBP synthesis in human cancer cell lines by steroid and thyroid hormones

1989 • 25 citations

Genetic variation of human sex hormone-binding globulin: evidence for a worldwide bi-allelic gene.

1992 • 22 citations

Intracellular sex hormone-binding globulin (SHBG) in normal and neoplastic breast tissue — an additional marker for hormone dependency?

2009 • 17 citations

Molecular characterization of a genetic variant of the steroid hormone-binding globulin gene in heterozygous subjects.

1995 • 16 citations

Control of the Membrane Sex Hormone-Binding Globulin-Receptor (SHBG-R) in MCF-7 Cells: Effect of Locally Produced SHBG

1998 • 14 citations

Genetic variation of human sex hormone-binding globulin: evidence for a worldwide bi-allelic gene

1992 • 12 citations

Sex Hormone‐Binding Globulin and the Natural History of Breast Cancer

1988 • 8 citations

Molecular characterization of a genetic variant of the steroid hormone- binding globulin gene in heterozygous subjects

1995 • 8 citations

Relationship between sex hormone binding globulin and estrogen receptors in breast cancer.

1984 • 7 citations

Mechanisms of sex-steroid accumulation in the aetiology of human breast carcinoma: the role of intracellular sex hormone binding globulin.

1988 • 6 citations

[Hormone replacement therapy in menopause: therapeutic benefits and preventive risks].

1997 • 1 citations