Spatial patterns of brain atrophy in MCI patients, identified via high-dimensional pattern classification, predict subsequent cognitive decline

Brain infarction and the clinical expression of Alzheimer disease. The Nun Study

1997 • 1,970 citations

Medical Image Computing and Computer-Assisted Intervention — MICCAI’98

1998 • 1,593 citations

Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment

1999 • 1,384 citations

Longitudinal Magnetic Resonance Imaging Studies of Older Adults: A Shrinking Brain

2003 • 1,383 citations

HAMMER: hierarchical attribute matching mechanism for elastic registration

2002 • 1,053 citations

Rates of hippocampal atrophy correlate with change in clinical status in aging and AD

2000 • 898 citations

Adaptive fuzzy segmentation of magnetic resonance images

1999 • 803 citations

Resampling-based false discovery rate controlling multiple test procedures for correlated test statistics

1999 • 735 citations

Classifying brain states and determining the discriminating activation patterns: Support Vector Machine on functional MRI data

2005 • 713 citations

Magnetic resonance imaging of the entorhinal cortex and hippocampus in mild cognitive impairment and Alzheimer's disease

2001 • 706 citations

Use of structural magnetic resonance imaging to predict who will get Alzheimer's disease

2000 • 642 citations

Diffusion tensor imaging and aging

2006 • 637 citations

Global and local gray matter loss in mild cognitive impairment and Alzheimer's disease

2004 • 585 citations

3D maps from multiple MRI illustrate changing atrophy patterns as subjects progress from mild cognitive impairment to Alzheimer's disease

2007 • 569 citations

White matter damage in Alzheimer's disease assessed in vivo using diffusion tensor magnetic resonance imaging

2002 • 561 citations

Hippocampal formation glucose metabolism and volume losses in MCI and AD

2001 • 555 citations

Mild cognitive impairment

2003 • 552 citations

Older adults with cognitive complaints show brain atrophy similar to that of amnestic MCI

2006 • 546 citations

One-year Age Changes in MRI Brain Volumes in Older Adults

2000 • 515 citations

Classifying spatial patterns of brain activity with machine learning methods: Application to lie detection

2005 • 479 citations

MRI-derived entorhinal and hippocampal atrophy in incipient and very mild Alzheimer’s disease ☆ ☆This research was supported by grants P01 AG09466 and P30 AG10161 from the National Institute on Aging, National Institutes of Health.

2001 • 472 citations

Cerebral White Matter Lesions and the Risk of Dementia

2004 • 471 citations

White matter changes in mild cognitive impairment and AD: A diffusion tensor imaging study

2005 • 444 citations

Cortical Change in Alzheimer's Disease Detected with a Disease-specific Population-based Brain Atlas

2001 • 441 citations

Early diagnosis of alzheimer’s disease: contribution of structural neuroimaging

2003 • 428 citations

Automatic Differentiation of Anatomical Patterns in the Human Brain: Validation with Studies of Degenerative Dementias

2002 • 423 citations

Cerebral infarctions and the likelihood of dementia from Alzheimer disease pathology

2004 • 423 citations

Specific Hippocampal Volume Reductions in Individuals at Risk for Alzheimer’s Disease

1997 • 412 citations

Voxel-Based Morphometry Using the RAVENS Maps: Methods and Validation Using Simulated Longitudinal Atrophy

2001 • 410 citations

Volume loss of the hippocampus and temporal lobe in healthy elderly persons destined to develop dementia

1997 • 403 citations

Detection of prodromal Alzheimer's disease via pattern classification of magnetic resonance imaging

2006 • 381 citations

Support vector machines for temporal classification of block design fMRI data

2005 • 380 citations

Computer-assisted imaging to assess brain structure in healthy and diseased brains

2003 • 371 citations

Mapping gray matter loss with voxel-based morphometry in mild cognitive impairment

2002 • 363 citations

COMPARE: Classification of Morphological Patterns Using Adaptive Regional Elements

2007 • 362 citations

Medial temporal lobe atrophy predicts Alzheimer's disease in patients with minor cognitive impairment.

2002 • 353 citations

Atrophy of the medial occipitotemporal, inferior, and middle temporal gyri in non-demented elderly predict decline to Alzheimer’s disease☆

2000 • 346 citations

Morphological classification of brains via high-dimensional shape transformations and machine learning methods

2003 • 339 citations

Usefulness of MRI measures of entorhinal cortex versus hippocampus in AD

2000 • 320 citations

PET amyloid ligand [ ¹¹ C]PIB uptake is increased in mild cognitive impairment

2007 • 320 citations

Preclinical detection of Alzheimer's disease: hippocampal shape and volume predict dementia onset in the elderly

2005 • 319 citations

Diffusion tensor imaging and aging – a review

2002 • 306 citations

Ultrastructural Hippocampal and White Matter Alterations in Mild Cognitive Impairment: A Diffusion Tensor Imaging Study

2004 • 305 citations

An Image-Processing System for Qualitative and Quantitative Volumetric Analysis of Brain Images

1998 • 297 citations

Relation of cerebral infarctions to dementia and cognitive function in older persons

2003 • 290 citations

Whole-Brain Morphometric Study of Schizophrenia Revealing a Spatially Complex Set of Focal Abnormalities

2005 • 268 citations

Color-coded diffusion-tensor-imaging of posterior cingulate fiber tracts in mild cognitive impairment

2005 • 265 citations

Longitudinal CSF and MRI biomarkers improve the diagnosis of mild cognitive impairment

2005 • 257 citations

A voxel based morphometry study on mild cognitive impairment

2004 • 221 citations

Diffusion tensor imaging in early Alzheimer's disease

2006 • 212 citations

Voxel-based detection of white matter abnormalities in mild Alzheimer disease

2006 • 208 citations

MRI predictors of risk of incident Alzheimer disease

2005 • 184 citations

Past adult lead exposure is linked to neurodegeneration measured by brain MRI

2006 • 183 citations

The contribution of voxel-based morphometry in staging patients with mild cognitive impairment

2006 • 175 citations

Very High-Resolution Morphometry Using Mass-Preserving Deformations and HAMMER Elastic Registration

2002 • 165 citations

3D Anatomical Atlas of the Human Brain

1998 • 163 citations

Diffusion Tensor Imaging of Frontal White Matter Microstructure in Early Alzheimer’s Disease: A Preliminary Study

2005 • 159 citations

Classification of Structural Images via High-Dimensional Image Warping, Robust Feature Extraction, and SVM

2005 • 149 citations

Brain MRI hippocampal volume and prediction of clinical status in a mild cognitive impairment trial

2002 • 149 citations

Hippocampus Volume Loss Due to Chronic Heavy Drinking

2006 • 149 citations

Hypoperfusion induces overexpression of β-amyloid precursor protein mRNA in a focal ischemic rodent model

2000 • 143 citations

Measuring Size and Shape of the Hippocampus in MR Images Using a Deformable Shape Model

2002 • 130 citations

Evolution of Alzheimer’s disease related cortical lesions

1998 • 129 citations

Hippocampal Shape Analysis of Alzheimer Disease Based on Machine Learning Methods

2007 • 123 citations

Unaffected Family Members and Schizophrenia Patients Share Brain Structure Patterns: A High-Dimensional Pattern Classification Study

2007 • 119 citations

Predicting conversion to dementia in mild cognitive impairment by volumetric and diffusivity measurements of the hippocampus

2006 • 118 citations

Alzheimer's disease and models of computation: Imaging, classification, and neural models

2005 • 117 citations

Expression and Distribution of Beta Amyloid Precursor Protein and Beta Amyloid Peptide in Reactive Astrocytes After Transient Middle Cerebral Artery Occlusion

2001 • 109 citations

Cleavage of amyloid precursor protein elicited by chronic cerebral hypoperfusion

2000 • 105 citations

Diffusion Tensor Imaging of Normal Appearing White Matter and Its Correlation with Cognitive Functioning in Mild Cognitive Impairment and Alzheimer's Disease

2007 • 101 citations

Discriminative MR Image Feature Analysis for Automatic Schizophrenia and Alzheimer’s Disease Classification

2004 • 98 citations

Mild Cognitive Impairment: Apparent Diffusion Coefficient in Regional Gray Matter and White Matter Structures

2006 • 64 citations

Cognitive decline in AD and mild cognitive impairment is associated with global brain damage

2002 • 61 citations

Progressive parenchymal deposition of β-amyloid precursor protein in rat brain following global cerebral ischemia

1999 • 51 citations

Post-ischemic changes in the expression of Alzheimerʼs APP isoforms in rat cerebral cortex

1998 • 46 citations

Neural networks for longitudinal studies in Alzheimer’s disease

2006 • 44 citations

Hypercortisolism in Alcohol Dependence and Its Relation to Hippocampal Volume Loss

2006 • 38 citations

The International Society for Magnetic Resonance in Medicine (ISMRM)

2012 • 33 citations

IEEE Computer Society Workshop on Mathematical Methods in Biomedical Image Analysis

2006 • 11 citations

On Characterizing and Analyzing Diffusion Tensor Images by Learning their Underlying Manifold Structure

2006 • 10 citations

Longitudinal changes in MRI volumes in older adults

2000 • 9 citations

SVM Based Feature Screening Applied To Hierarchical Cervical Cancer Detection

2003 • 8 citations

Manifold Based Analysis of Diffusion Tensor Images Using Isomaps

2006 • 7 citations

Abnormal White Matter Organization in Huntington's Disease Evaluated with Diffusion Tensor MRI

2003 • 5 citations

IC–P–035: Complex patterns of structural brain abnormality identified in MCI via high–dimensional pattern classification of MR images may be early markers of Alzheimer's disease

2006 • 2 citations