NMR and molecular modeling study of the conformations of taxol and of its side chain methylester in aqueous and non-aqueous solution.

Plant antitumor agents. VI. Isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia

1971 • 3,891 citations

Macromodel—an integrated software system for modeling organic and bioorganic molecules using molecular mechanics

1990 • 3,683 citations

Semianalytical treatment of solvation for molecular mechanics and dynamics

1990 • 3,585 citations

Promotion of microtubule assembly in vitro by taxol

1979 • 3,521 citations

Conformational analysis. 130. MM2. A hydrocarbon force field utilizing V1 and V2 torsional terms

1977 • 3,502 citations

Taxol stabilizes microtubules in mouse fibroblast cells.

1980 • 1,942 citations

Taxol: A Unique Antineoplastic Agent with Significant Activity in Advanced Ovarian Epithelial Neoplasms

1989 • 1,111 citations

Taxol: A Novel Investigational Antimicrotubule Agent

1990 • 1,084 citations

Phase II Trial of Taxol, an Active Drug in the Treatment of Metastatic Breast Cancer

1991 • 730 citations

Conformations of cycloheptadecane. A comparison of methods for conformational searching

1990 • 501 citations

Taxol: an antimitotic agent with a new mechanism of action

1984 • 483 citations

Experimental antitumor activity of taxotere (RP 56976, NSC 628503), a taxol analogue.

1991 • 480 citations

Taxol: Mechanisms of Action and Resistancea

1986 • 415 citations

A practical, highly enantioselective synthesis of the taxol side chain via asymmetric catalysis.

1992 • 298 citations

The MMP2 calculational method

1987 • 221 citations

The Reactions of Aliphatic Acid Chlorides.

1953 • 217 citations

Biologically active taxol analogs with deleted A-ring side chain substituents and variable C-2' configurations

1991 • 181 citations

An improved synthesis of the taxol side chain and of RP 56976

1990 • 178 citations

An efficient, enantioselective synthesis of the taxol side chain

1986 • 173 citations

Efficient and practical asymmetric synthesis of the taxol C-13 side chain, N-benzoyl-(2R,3S)-3-phenylisoserine, and its analogs via chiral 3-hydroxy-4-aryl-.beta.-lactams through chiral ester enolate-imine cyclocondensation

1991 • 171 citations

Direct Photoaffinity Labeling of Tubulin With Taxol

1992 • 156 citations

Antileukemic alkaloids from Taxus wallichiana Zucc

1981 • 148 citations

Direct, highly efficient synthesis from (S)-(+)-phenylglycine of the taxol and taxotere side chains

1991 • 110 citations

¹H- and ¹³C-nmr Assignments for Taxol, 7-epi-Taxol, and Cephalomannine

1992 • 107 citations

Characterization of taxol in methylene chloride by nmr spectroscopy

1992 • 45 citations

On the out-of-plane deformation of aromatic rings, and its representation by molecular mechanics

1987 • 43 citations

Taxol: Quantitative Internuclear Proton-Proton Distances in CDCl₃ Solution from nOe Data: 2D NMR Roesy Buildup Rates at 500 MHz

1992 • 33 citations

Nuclear Overhauser Effect Spectroscopy (NOESY) and Dihedral Angle Measurements in the Determination of the Conformation of Taxol in Solution

1992 • 26 citations

X-ray structure and crystal lattice interactions of the taxol side-chain methyl ester.

1991 • 11 citations

Communications- The Reaction of Aminomethyltrimethylsilane with Nitrous Acid.

1961 • 7 citations