Charge-modified single chain antibody constructs of monoclonal antibody CC49: generation, characterization, pharmacokinetics, and biodistribution analysis

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

[21] Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction

1987 • 5,745 citations

Human colonic adenocarcinoma cells

1976 • 375 citations

Construction, binding properties, metabolism, and tumor targeting of a single-chain Fv derived from the pancarcinoma monoclonal antibody CC49.

1991 • 342 citations

In Vivo Tumor Targeting of a Recombinant Single-Chain Antigen-Binding Protein

1990 • 304 citations

THE ROLE OF THE KIDNEY IN THE CATABOLISM OF BENCE JONES PROTEINS AND IMMUNOGLOBULIN FRAGMENTS

1967 • 295 citations

Generation and characterization of B72.3 second generation monoclonal antibodies reactive with the tumor-associated glycoprotein 72 antigen.

1988 • 210 citations

Radiolocalization of human mammary tumors in athymic mice by a monoclonal antibody.

1983 • 208 citations

The rapid determination of binding constants for antiviral antibodies by a radioimmunoassay. An analysis of the interaction between hybridoma proteins and influenza virus

1979 • 187 citations

Reduction of the renal uptake of radiolabeled monoclonal antibody fragments by cationic amino acids and their derivatives.

1995 • 158 citations

Conformational stability, folding, and ligand-binding affinity of single-chain Fv immunoglobulin fragments expressed in Escherichia coli

1991 • 145 citations

Radioimmunolocalization of human carcinoma xenografts with B72.3 second generation monoclonal antibodies.

1988 • 140 citations

Microautoradiographic analysis of the normal organ distribution of radioiodinated single-chain Fv and other immunoglobulin forms.

1993 • 111 citations

Enhanced tumor binding using immunohistochemical analyses by second generation anti-tumor-associated glycoprotein 72 monoclonal antibodies versus monoclonal antibody B72.3 in human tissue.

1990 • 100 citations

Anti-murine antibody response to mouse monoclonal antibodies: Clinical findings and implications

1989 • 89 citations

Gamma imaging with negatively charge-modified monoclonal antibody: modification with synthetic polymers.

1991 • 71 citations

L-lysine effectively blocks renal uptake of 125I- or 99mTc-labeled anti-Tac disulfide-stabilized Fv fragment.

1996 • 66 citations

Differential metabolic patterns of iodinated versus radiometal chelated anticarcinoma single-chain Fv molecules.

1992 • 58 citations

Prevention of renal tubule re-absorption of radiometal (indium-111) labelled Fab fragment of a monoclonal antibody in mice by systemic administration of lysine

1994 • 46 citations

Biodistribution of 18F- and 125I-labeled anti-Tac disulfide-stabilized Fv fragments in nude mice with interleukin 2 alpha receptor-positive tumor xenografts.

1995 • 43 citations

Lysine reduces renal accumulation of radioactivity associated with injection of the [177Lu]alpha-[2-(4-aminophenyl) ethyl]-1,4,7,10-tetraaza-cyclodecane-1,4,7,10-tetraacetic acid-CC49 Fab radioimmunoconjugate.

1995 • 36 citations

Construction of penP delta 1, Bacillus licheniformis 749/C beta-lactamase lacking site for lipoprotein modification. Expression in Escherichia coli and Bacillus subtilis.

1983 • 35 citations

Site-specific photobiotinylation of immunoglobulins, fragments and light chain dimers

1997 • 22 citations

Altered pharmacokinetic and tumour localization properties of Fab' fragments of a murine monoclonal anti-CEA antibody by covalent modification with low molecular weight dextran

1995 • 19 citations

Preferential use of a H chain V region in antitumor-associated glycoprotein-72 monoclonal antibodies.

1993 • 16 citations

Effect of acetylation on monoclonal antibody ZCE-025 Fab': distribution in normal and tumor-bearing mice.

1990 • 9 citations

Does the in vitro testing of the immunoreactivity of an antibody reflect its in vivo behavior?

1988 • 8 citations