RNA tectonics: towards RNA design

Systematic Evolution of Ligands by Exponential Enrichment: RNA Ligands to Bacteriophage T4 DNA Polymerase

1990 • 9,690 citations

In vitro selection of RNA molecules that bind specific ligands

1990 • 9,093 citations

Principles of Nucleic Acid Structure

2008 • 4,570 citations

The structure of proteins: Two hydrogen-bonded helical configurations of the polypeptide chain

1951 • 2,750 citations

The RNA world

1986 • 1,961 citations

Principles of Nucleic Acid Structure

1985 • 1,497 citations

Are there pathways for protein folding?

1968 • 1,496 citations

Selection in vitro of an RNA enzyme that specifically cleaves single-stranded DNA

1990 • 1,270 citations

Modelling of the three-dimensional architecture of group I catalytic introns based on comparative sequence analysis

1990 • 1,239 citations

Three-dimensional structure of a hammerhead ribozyme

1994 • 944 citations

Crystal structure at 1.92 Å resolution of the RNA-binding domain of the U1A spliceosomal protein complexed with an RNA hairpin

1994 • 827 citations

Nucleic Acids and Molecular Biology

1994 • 777 citations

THE CATALYTIC MECHANISM AND STRUCTURE OF THYMIDYLATE SYNTHASE

1995 • 723 citations

Probing the structure of RNAs in solution

1987 • 721 citations

RNA Chaperones and the RNA Folding Problem

1995 • 702 citations

The crystal structure of an AII-RNAhammerhead ribozyme: A proposed mechanism for RNA catalytic cleavage

1995 • 675 citations

POSTTRANSCRIPTIONAL REGULATORY MECHANISMS IN ESCHERICHIA COLI

1988 • 670 citations

Dissecting the catalytic triad of a serine protease

1988 • 621 citations

Comparison of fungal mitochondrial introns reveals extensive homologies in RNA secondary structure

1982 • 501 citations

Crystallographic refinement of yeast aspartic acid transfer RNA

1985 • 498 citations

Levinthal's paradox.

1992 • 495 citations

Coaxial stacking of helixes enhances binding of oligoribonucleotides and improves predictions of RNA folding.

1994 • 474 citations

SMALL CATALYTIC RNAs

1992 • 455 citations

Context-dependent secondary structure formation of a designed protein sequence

1996 • 395 citations

CUUCGG hairpins: extraordinarily stable RNA secondary structures associated with various biochemical processes.

1988 • 357 citations

Frequent use of the same tertiary motif by self-folding RNAs.

1995 • 354 citations

A pseudoknot-like structure required for efficient self-cleavage of hepatitis delta virus RNA

1991 • 339 citations

Kinetic Intermediates in RNA Folding

1994 • 306 citations

Representation of the secondary and tertiary structure of group I introns

1994 • 293 citations

Interactions of a small RNA with antibiotic and RNA ligands of the 30S subunit

1994 • 286 citations

Molecular Recognition of Amino Acids by RNA-Aptamers: An L-Citrulline Binding RNA Motif and Its Evolution into an L-Arginine Binder

1994 • 280 citations

Model for an RNA tertiary interaction from the structure of an intermolecular complex between a GAAA tetraloop and an RNA helix

1994 • 276 citations

Progress in Biophysics and Molecular Biology

1978 • 275 citations

GAAA Tetraloop and Conserved Bulge Stabilize Tertiary Structure of a Group I Intron Domain

1994 • 246 citations

Specificity of ribonucleoprotein interaction determined by RNA folding during complex formation

1996 • 245 citations

Involvement of a GNRA tetraloop in long-range RNA tertiary interactions

1994 • 241 citations

A novel RNA structural motif in the selenocysteine insertion element of eukaryotic selenoprotein mRNAs.

1996 • 230 citations

The conformation of loop E of eukaryotic 5S ribosomal RNA

1993 • 229 citations

Isolation of RNA Aptamers for Biological Cofactors by In Vitro Selection

1994 • 221 citations

Molecular Recognition in the FMN – RNA Aptamer Complex

1996 • 217 citations

An independently folding domain of RNA tertiary structure within the Tetrahymena ribozyme

1993 • 214 citations

The secondary structure of ribonuclease P RNA, the catalytic element of a ribonucleoprotein enzyme

1988 • 213 citations

The Structure of an RNA Pseudoknot that Causes Efficient Frameshifting in Mouse Mammary Tumor Virus

1995 • 196 citations

Prion Protein Peptides Induce .alpha.-Helix to .beta.-Sheet Conformational Transitions

1995 • 192 citations

NMR studies of amyloid .beta.-peptides: proton assignments, secondary structure, and mechanism of an .alpha.-helix .fwdarw. .beta.-sheet conversion for a homologous, 28-residue, N-terminal fragment

1992 • 184 citations

Structural and functional aspects of RNA pseudoknots

1992 • 184 citations

Structural Basis of Ligand Discrimination by Two Related RNA Aptamers Resolved by NMR Spectroscopy

1996 • 179 citations

RNA bulges and the helical periodicity of double-stranded RNA

1990 • 163 citations

4 Probing RNA Structure, Function, and History by Comparative Analysis

1993 • 160 citations

A three-dimensional model of hepatitis delta virus ribozyme based on biochemical and mutational analyses

1994 • 145 citations

Assembly of a Ribonucleoprotein Catalyst by Tertiary Structure Capture

1996 • 142 citations

Computer modeling from solution data of spinach chloroplast and of Xenopus laevis somatic and oocyte 5 S rRNAs

1989 • 136 citations

Higher order folding and domain analysis of the ribozyme from Bacillus subtilis ribonuclease P

1995 • 131 citations

Pseudoknots: a new motif in the RNA game

1990 • 131 citations

Transcription attenuation.

1988 • 128 citations

Bent Helix Formation Between RNA Hairpins with Complementary Loops

1995 • 127 citations

Reconstitution of a group I intron self-splicing reaction with an activator RNA.

1991 • 123 citations

Recognition of the high affinity binding site in rev-response element RNA by the Human Immunodeficiency Virus type-1 rev protein

1992 • 119 citations

Comparative analysis of ribonuclease P RNA using gene sequences from natural microbial populations reveals tertiary structural elements.

1996 • 116 citations

Inventing and improving ribozyme function: Rational design versus iterative selection methods

1994 • 114 citations

Conformational switching in designed peptides: the helix/sheet transition

1996 • 111 citations

A Tyrosyl-tRNA Synthetase Protein Induces Tertiary Folding of the Group I Intron Catalytic Core

1996 • 110 citations

The kinetic folding pathway of the Tetrahymena ribozyme reveals possible similarities between RNA and protein folding

1996 • 109 citations

Control of colE1 plasmid replication

1990 • 107 citations

The neurospora CYT-18 protein suppresses defects in the phage T4 td intron by stabilizing the catalytically active structure of the intron core

1992 • 106 citations

An Analysis of the Structure of tRNA

1975 • 102 citations

Monitoring of the Cooperative Unfolding of the sunY Group I Intron of Bacteriophage T4

1993 • 101 citations

Three-dimensional model of the active site of the self-splicing rRNA precursor of Tetrahymena.

1987 • 99 citations

Control of replication of plasmid R1: structures and sequences of the antisense RNA, CopA, required for its binding to the target RNA, CopT.

1990 • 98 citations

[17] A guide for probing native small nuclear RNA and ribonucleoprotein structures

1989 • 98 citations

A tyrosyl-tRNA synthetase binds specifically to the group I intron catalytic core.

1992 • 97 citations

Activity and thermostability of the small self-splicing group I intron in the pre-tRNA(lle) of the purple bacterium Azoarcus.

1996 • 96 citations

Crystallization of ribozymes and small RNA motifs by a sparse matrix approach.

1993 • 96 citations

Movement of the Guide Sequence During RNA Catalysis by a Group I Ribozyme

1993 • 95 citations

Three-dimensional model of Escherichia coli ribosomal 5 S RNA as deduced from structure probing in solution and computer modeling

1991 • 93 citations

Pre‐mRNA secondary structure and the regulation of splicing

1993 • 89 citations

Solution Structure of the 3′-End of Brome Mosaic Virus Genomic RNAs

1994 • 86 citations

Self-assembly of a group I intron active site from its component tertiary structural domains.

1995 • 86 citations

Determinants of RNA Hairpin Loop-Loop Complex Stability

1995 • 81 citations

Solution structure of mRNA hairpins promoting selenocysteine incorporation in Escherichia coli and their base-specific interaction with special elongation factor SELB.

1996 • 76 citations

RNA pseudoknots

1992 • 72 citations

The global folding of four-way helical junctions in RNA, including that in U1 snRNA

1995 • 70 citations

Mapping in Three Dimensions of Regions in a Catalytic RNA Protected from Attack by an Fe(II)-EDTA Reagent

1996 • 70 citations

Solution structure of human U1 snRNA. Derivation of a possible three-dimensional model

1990 • 68 citations

Coaxially Stacked RNA Helices in the Catalytic Center of the Tetrahymena Ribozyme

1994 • 61 citations

A central pseudoknotted three-way junction imposes tRNA-like mimicry and the orientation of three 5' upstream pseudoknots in the 3' terminus of tobacco mosaic virus RNA.

1996 • 61 citations

Selection and characterization of randomly produced mutants in the gene coding for M1 RNA

1988 • 59 citations

Minimum secondary structure requirements for catalytic activity of a self-splicing group I intron

1990 • 57 citations

Function of P11, a tertiary base pairing in self-splicing introns of subgroup IA

1991 • 56 citations

Peptide antibiotics of the tuberactinomycin family as inhibitors of group I intron RNA splicing

1994 • 56 citations

The structure of transfer RNA

1971 • 55 citations

Molecular dissection of the pseudoknot governing the translational regulation ofEscherichia coilribosomal protein S15

1995 • 50 citations

The Structure of Group I Ribozymes

1996 • 44 citations

Minimal 16S rRNA binding site and role of conserved nucleotides in Escherichia coli ribosomal protein S8 recognition

1993 • 42 citations

Visualization of a Tertiary Structural Domain of the Tetrahymena Group I Intron by Electron Microscopy

1994 • 40 citations

The Influence of Symmetric Internal Loops on the Flexibility of RNA

1996 • 35 citations

A Tyrosyl-tRNA Synthetase Suppresses Structural Defects in the Two Major Helical Domains of the Group I Intron Catalytic Core

1996 • 35 citations

tRNA—A Treasury of Stereochemical Information

1984 • 17 citations