Perils and Pitfalls in the Interpretation of Clinical Trials: A Reflection on the Recent Experience in Multiple Sclerosis

New diagnostic criteria for multiple sclerosis: Guidelines for research protocols

1983 • 7,404 citations

More powerful procedures for multiple significance testing

1990 • 2,572 citations

Intramuscular interferon beta‐1a for disease progression in relapsing multiple sclerosis

1996 • 2,410 citations

Interferon beta‐1b is effective in relapsing‐remitting multiple sclerosis

1993 • 1,908 citations

A Randomized, Controlled Trial of Corticosteroids in the Treatment of Acute Optic Neuritis

1992 • 1,254 citations

Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. I. Clinical results of a multicenter, randomized, double-blind, placebo-controlled trial. The IFNB Multiple Sclerosis Study Group.

1993 • 1,227 citations

Procedures for Comparing Samples with Multiple Endpoints

1984 • 1,166 citations

The Effect of Corticosteroids for Acute Optic Neuritis on the Subsequent Development of Multiple Sclerosis

1993 • 572 citations

p Values, Hypothesis Tests, and Likelihood: Implications for Epidemiology of a Neglected Historical Debate

1993 • 291 citations

Cladribine in treatment of chronic progressive multiple sclerosis

1994 • 284 citations

Baseline Visual Field Profile of Optic Neuritis

1993 • 194 citations

THE PROBLEM OF MULTIPLE INFERENCE IN STUDIES DESIGNED TO GENERATE HYPOTHESES

1985 • 194 citations

Side Effects of Glucocorticoid Treatment

1993 • 154 citations

Fellow Eye Abnormalities in Acute Unilateral Optic Neuritis

1993 • 91 citations

Design, methods, and conduct of the optic neuritis treatment trial

1993 • 86 citations

Cooperative study in the evaluation of therapy in multiple sclerosis; ACTH vs placebo in acute exacerbations

1968 • 82 citations

Quality control functions of the Visual Field Reading Center (VFRC) for the Optic Neuritis Treatment Trial (ONTT)

1993 • 57 citations

Single-leg strut fractures in explanted Björk-Shiley valves

1994 • 55 citations

A possible harmful late effect of methylprednisolone therapy on a time cluster of optic neuritis

1989 • 22 citations

Invited Commentary: p Values, Hypothesis Tests, and Likelihood

1993 • 13 citations