Modeling and E-M Estimation of Haplotype-Specific Relative Risks from Genotype Data for a Case-Control Study of Unrelated Individuals

Maximum Likelihood from Incomplete Data Via the EM Algorithm

1977 • 46,601 citations

The Future of Genetic Studies of Complex Human Diseases

1996 • 5,355 citations

Finding the Observed Information Matrix When Using the EM Algorithm

1982 • 2,055 citations

Maximum-likelihood estimation of molecular haplotype frequencies in a diploid population.

1995 • 1,977 citations

Score Tests for Association between Traits and Haplotypes when Linkage Phase Is Ambiguous

2002 • 1,798 citations

High-resolution haplotype structure in the human genome

2001 • 1,752 citations

Logistic disease incidence models and case-control studies

1979 • 1,064 citations

A Multiethnic Cohort in Hawaii and Los Angeles: Baseline Characteristics

2000 • 964 citations

Testing Association of Statistically Inferred Haplotypes with Discrete and Continuous Traits in Samples of Unrelated Individuals

2002 • 677 citations

Genetic Analysis of Case/Control Data Using Estimated Haplotype Frequencies: Application to APOE Locus Variation and Alzheimer's Disease

2001 • 432 citations

Model-Free Analysis and Permutation Tests for Allelic Associations

1999 • 423 citations

Choosing Haplotype-Tagging SNPS Based on Unphased Genotype Data Using a Preliminary Sample of Unrelated Subjects with an Example from the Multiethnic Cohort Study

2003 • 413 citations

Genome screening by searching for shared segments: mapping a gene for benign recurrent intrahepatic cholestasis

1994 • 325 citations

Correction of Logistic Regression Relative Risk Estimates and Confidence Intervals for Random Within-Person Measurement Error

1992 • 265 citations

Exposure stratified case-cohort designs.

2000 • 264 citations

A Method for the Assessment of Disease Associations with Single-Nucleotide Polymorphism Haplotypes and Environmental Variables in Case-Control Studies

2003 • 174 citations

A Course in Theortical Statistics.

1970 • 159 citations

Linkage Disequilibrium Analysis of Biallelic DNA Markers, Human Quantitative Trait Loci, and Threshold-Defined Case and Control Subjects

2000 • 88 citations

Head Injury as a Risk Factor for Brain Tumors in Children: Results from a Multicenter Case-Control Study

1996 • 80 citations

Haplotype sharing analysis in affected individuals from nuclear families with at least one affected offspring

1997 • 61 citations

Estimation of Multilocus Haplotype Effects Using Weighted Penalised Log‐Likelihood: Analysis of Five Sequence Variations at the Cholesteryl Ester Transfer Protein Gene Locus

2003 • 43 citations

Genomic sharing surrounding alleles identical by descent: Effects of genetic drift and population growth

1997 • 33 citations

Linkage disequilibrium mapping in populations of variable size using the decay of haplotype sharing and a stepwise-mutation model

2000 • 13 citations

An efficient, robust, and unified method for mapping complex traits (II): Multipoint linkage analysis

1998 • 8 citations