Characteristics of methotrexate polyglutamate formation in cultured hepatic cells

Isolation and biochemical characterization of folate deficient mutants of chinese hamster cells

1974 • 277 citations

Enzymatic synthesis of folylpolyglutamates. Characterization of the reaction and its products.

1980 • 215 citations

Polygammaglutamyl metabolites of methotrexate

1973 • 171 citations

Evidence for the cytotoxic activity of polyglutamate derivatives of methotrexate.

1980 • 147 citations

Correlates of folate analog transport, pharmacokinetics and selective antitumor action

1980 • 135 citations

Folate-dependent enzymes in cultured Chinese hamster cells: Folylpolyglutamate synthetase and its absence in mutants auxotrophic for glycine + adenosine + thymidine

1977 • 133 citations

Identification of folic acid compounds in rat liver

1972 • 123 citations

Transport and metabolism of methotrexate in normal and resistant cultured rat hepatoma cells.

1979 • 118 citations

The identification of pteroylpentaglutamate as the major folate derivative in rat liver and the demonstration of its biosynthesis from exogenous [3H] pteroylglutamate

1972 • 102 citations

Efflux of methotrexate and its polyglutamate derivatives from hepatic cells in vitro.

1981 • 89 citations

Synthesis of methotrexate polyglutamates in L1210 murine leukemia cells.

1977 • 86 citations

Stoichiometric inhibition of mammalian dihydrofolate reductase by the γ-glutamyl metabolite of methotrexate, 4-amino-4-deoxy-N10-methylpteroylglutamyl-γ-glutamate

1975 • 81 citations

Prolonged inhibition of DNA synthesis associated with the accumulation of methotrexate polyglutamates by cultured human cells.

1978 • 78 citations

Transport of 5-methyltetrahydrofolic acid and folic acid in freshly isolated hepatocytes.

1978 • 61 citations

Formation of methotrexate polyglutamates in rat hepatocytes.

1979 • 58 citations

Hepatic Folate in Man

1966 • 55 citations

Synthesis of methotrexate polyglutamates in cultured human cells.

1978 • 54 citations

Uptake of pteroyl[¹⁴C]glutamic acid into rat liver and its incorporation into the natural pteroyl poly-γ-glutamates of that organ

1974 • 54 citations

Transport, binding, and polyglutamation of methotrexate in freshly isolated rat hepatocytes.

1980 • 53 citations

A functional, active transport system for methotrexate in freshly isolated hepatocytes

1976 • 49 citations

Characterization of a chinese hamster cell with a temperature-sensitive mutation in folate metabolism

1974 • 40 citations

Enzymic preparations of radiolabeled (+)-l-5-methyltetrahydrofolate and (+)-l-5-formyltetrahydrofolate

1971 • 39 citations

5-Methyltetrahydrofolate transport by hepatoma cells and methotrexate-resistant sublines in culture.

1981 • 38 citations

Extracellular recovery of methotrexate-polyglutamates following efflux from L1210 leukemia cells

1980 • 35 citations

Membrane characteristics of adult rat liver parenchymal cells in primary monolayer culture

1980 • 32 citations

Growth inhibitory, transport and biochemical properties of the γ-glutamyl and γ-aspartyl peptides of methotrexate inL1210 leukemia cells in vitro

1978 • 29 citations

An inverse relationship of rat liver folate polyglutamate chain length to nutritional folate sufficiency

1980 • 28 citations

Potent bile salt and organic anion inhibition of methotrexate uptake and accumulation in the freshly isolated rat hepatocyte.

1980 • 25 citations

Folates of rat tissue

1979 • 24 citations

The assay of folic-acid activity of liver

1964 • 22 citations

Transport of methotrexate by primary cultures of rat hepatocytes: Stimulation of uptake in vitro by the presence of hormones in the medium

1981 • 18 citations

Inhibition of methotrexate polyglutamate accumulation in cultured human cells.

1981 • 17 citations

MEMBRANE CHARACTERISTICS OF PRIMARY HEPATOCYTE CULTURES AND A STABLE HEPATOCARCINOMA CELL LINE*

1980 • 14 citations