Requirements for self-splicing of a group I intron fromPhysarum polycephalum

[19] Rapid and efficient site-specific mutagenesis without phenotypic selection

1987 • 5,413 citations

SELF-SPLICING OF GROUP I INTRONS

1990 • 852 citations

Enzyme Structure and Mechanism

1978 • 573 citations

Site specific enzymatic cleavage of RNA

1979 • 400 citations

Autocatalytic cyclization of an excised intervening sequence RNA is a cleavage–ligation reaction

1983 • 287 citations

Specific interaction between the self-splicing RNA of Tetrahymena and its guanosine substrate: implications for biological catalysis by RNA

1984 • 263 citations

Sequence-specific endoribonuclease activity of the Tetrahymena ribozyme: enhanced cleavage of certain oligonucleotide substrates that form mismatched ribozyme-substrate complexes

1988 • 251 citations

An independently folding domain of RNA tertiary structure within the Tetrahymena ribozyme

1993 • 214 citations

One binding site determines sequence specificity of Tetrahymena pre-rRNA self-splicing, trans-splicing, and RNA enzyme activity

1986 • 211 citations

RNA splicing in neurospora mitochondria: Self-splicing of a mitochondrial intron in vitro

1984 • 187 citations

Reverse self-splicing of the tetrahymena group I intron: Implication for the directionality of splicing and for intron transposition

1989 • 178 citations

A Labile Phosphodiester Bond at the Ligation Junction in a Circular Intervening Sequence RNA

1984 • 171 citations

A mobile group I intron in the nuclear rDNA of physarum polycephalum

1989 • 158 citations

Intermolecular exon ligation of the rRNA precursor of tetrahymena: Oligonucleotides can function as 5′ exons

1985 • 114 citations

The effect of actinomycin D on the timing of mitosis in Physarum polycephalum

1965 • 109 citations

RNA catalysis by a group I ribozyme. Developing a model for transition state stabilization.

1992 • 108 citations

Ribozyme inhibitors. Deoxyguanosine and dideoxyguanosine are competitive inhibitors of self-splicing of the Tetrahymena ribosomal ribonucleic acid precursor

1986 • 101 citations

Characterization of I-Ppo, an Intron-Encoded Endonuclease That Mediates Homing of a Group I Intron in the Ribosomal DNA of Physarum polycephalum

1990 • 99 citations

A compilation of large subunit (23S-like) ribosomal RNA sequences presented in a secondary structure format

1990 • 86 citations

Alternative secondary structures in the 5' exon affect both forward and reverse self-splicing of the Tetrahymena intervening sequence RNA

1991 • 83 citations

Complete nucleotide sequence of the 26S rRNA gene of Physarum polycephalum: its significance in gene evolution.

1983 • 77 citations

The self-splicing RNA of Tetrahymena is trapped in a less active conformation by gel purification

1990 • 76 citations

A self-splicing group I intron in the nuclear pre-rRNA of the green alga,Ankistrodesmus stipitatus

1991 • 54 citations

Self-splicing of the group I intron from Anabaena pre-tRNA: Requirement for base-pairing of the exons in the anticodon stem

1993 • 53 citations

Self-splicing of the Tetrahymena pre-rRNA is decreased by misfolding during transcription

1993 • 52 citations

Binding of the CBP2 protein to a yeast mitochondrial group I intron requires the catalytic core of the RNA.

1991 • 45 citations

Bacteriophage introns: parasites within parasites?

1989 • 39 citations

Miniribozymes, small derivatives of the sunY intron, are catalytically active.

1989 • 39 citations

Site-directed mutagenesis of core sequence elements 9R', 9L, 9R, and 2 in self-splicing Tetrahymena pre-rRNA.

1987 • 39 citations

An alternative helix in the 26S rRNA promotes excision and integration of the Tetrahymena intervening sequence.

1993 • 36 citations

Exon sequence distant from the splic junction are required fo0r efficient self-splicing of theTetrahymena IVA

1992 • 35 citations

Stereoselective arginine binding is a phylogenetically conserved property of group I self-splicing RNAs.

1989 • 35 citations

Characterization of the self-splicing products of a mobile intron from the nuclear rDNA ofPhysarum polycephalum

1992 • 30 citations

An Alternative Helix in the 26S rRNA Promotes Excision and Integration of the Tetrahymena Intervening Sequence

1993 • 17 citations

The catalytic core of the sunY intron of bacteriophage T4

1989 • 14 citations