Transcriptional Activation of the cyclin D1 Gene Is Mediated by Multiple Cis-Elements, Including SP1 Sites and a cAMP-responsive Element in Vascular Endothelial Cells

The pathogenesis of atherosclerosis: a perspective for the 1990s

1993 • 10,730 citations

Transcriptional Regulation in Mammalian Cells by Sequence-Specific DNA Binding Proteins

1989 • 3,219 citations

G1 phase progression: Cycling on cue

1994 • 2,706 citations

Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain

1987 • 1,640 citations

Purification and Biochemical Characterization of the Promoter-Specific Transcription Factor, Sp1

1986 • 1,473 citations

NF-κB Controls Cell Growth and Differentiation through Transcriptional Regulation of Cyclin D1

1999 • 1,282 citations

Coupling of the RAS-MAPK Pathway to Gene Activation by RSK2, a Growth Factor-Regulated CREB Kinase

1996 • 1,253 citations

Integration of MAP Kinase Signal Transduction Pathways at the Serum Response Element

1995 • 935 citations

Efficient generation of recombinant adenoviruses using adenovirus DNA-terminal protein complex and a cosmid bearing the full-length virus genome.

1996 • 804 citations

Transforming p21 Mutants and c-Ets-2 Activate the Cyclin D1 Promoter through Distinguishable Regions

1995 • 803 citations

NF-κB Function in Growth Control: Regulation of Cyclin D1 Expression and G₀/G₁-to-S-Phase Transition

1999 • 777 citations

Sp1-mediated transcriptional activation is repressed by Sp3.

1994 • 692 citations

Cyclins and cyclin-dependent kinases: a biochemical view

1995 • 533 citations

Isolation and characterization of a newly identified endothelial cell mitogen produced by AtT-20 cells.

1989 • 497 citations

Ras Links Growth Factor Signaling to the Cell Cycle Machinery via Regulation of Cyclin D1 and the Cdk Inhibitor p27^KIP1

1997 • 409 citations

Estrogen induction of the cyclin D1 promoter: Involvement of a cAMP response-like element

1999 • 358 citations

Transcriptional regulation of the cyclin D1 promoter by STAT5: its involvement in cytokine-dependent growth of hematopoietic cells

1999 • 341 citations

p42/p44 MAP Kinase Module Plays a Key Role in the Transcriptional Regulation of the Vascular Endothelial Growth Factor Gene in Fibroblasts

1998 • 321 citations

Integration of Rac-dependent Regulation of Cyclin D1 Transcription through a Nuclear Factor-κB-dependent Pathway

1999 • 289 citations

Transforming Growth Factor β Activates the Promoter of Cyclin-dependent Kinase Inhibitor p15 through an Sp1 Consensus Site

1995 • 249 citations

Fos Family Members Induce Cell Cycle Entry by Activating Cyclin D1

1998 • 241 citations

pp60v- Induction of Cyclin D1 Requires Collaborative Interactions between the Extracellular Signal-regulated Kinase, p38, and Jun Kinase Pathways

1999 • 227 citations

Ikappa Balpha is a target for the mitogen-activated 90kDa ribosomal S6 kinase

1997 • 225 citations

Extracellular Signal-regulated Protein Kinase/Jun Kinase Cross-talk Underlies Vascular Endothelial Cell Growth Factor-induced Endothelial Cell Proliferation

1998 • 216 citations

Raf-1 protein kinase activates the NF-kappa B transcription factor by dissociating the cytoplasmic NF-kappa B-I kappa B complex.

1993 • 209 citations

The 90-kDa Ribosomal S6 Kinase (pp90rsk) Phosphorylates the N-terminal Regulatory Domain of IκBα and Stimulates Its Degradation in Vitro

1997 • 207 citations

Sp1 recognition sites in the proximal promoter of the human vascular endothelial growth factor gene are essential for platelet-derived growth factor-induced gene expression

1997 • 202 citations

Sp1 Phosphorylation by Erk 2 Stimulates DNA Binding

1999 • 201 citations

Sp1 Trans-Activation of Cell Cycle Regulated Promoters Is Selectively Repressed by Sp3

1995 • 193 citations

Kappa B site-dependent induction of gene expression by diverse inducers of nuclear factor kappa B requires Raf-1.

1993 • 189 citations

Ras Activity Late in G₁ Phase Required for p27^kip1 Downregulation, Passage through the Restriction Point, and Entry into S Phase in Growth Factor-Stimulated NIH 3T3 Fibroblasts

1997 • 169 citations

Identification of the cyclin D1 gene as a target of activating transcription factor 2 in chondrocytes

1999 • 159 citations

Nerve Growth Factor Induces Transcription of the p21 WAF1/CIP1 and Cyclin D1 Genes in PC12 Cells by Activating the Sp1 Transcription Factor

1997 • 156 citations

Endothelin stimulates phosphatidylinositol hydrolysis and DNA synthesis in brain capillary endothelial cells

1990 • 149 citations

Angiotensin II Activation of Cyclin D1-dependent Kinase Activity

1996 • 139 citations

Involvement of the Sp3 Transcription Factor in Induction of p21 in Keratinocyte Differentiation

1997 • 134 citations

Transcriptional Regulation of the Elastin Gene by Insulin-like Growth Factor-I Involves Disruption of Sp1 Binding

1995 • 86 citations

Epidermal Growth Factor Stimulation of the Human Gastrin Promoter Requires Sp1

1995 • 85 citations

Activation of nuclear factor-kappaB via T cell receptor requires a Raf kinase and Ca2+ influx. Functional synergy between Raf and calcineurin.

1996 • 76 citations

Reentry into the Cell Cycle of Contact-inhibited Vascular Endothelial Cells by a Phosphatase Inhibitor

2000 • 75 citations

Ras induces p21Cip1/Waf1 cyclin kinase inhibitor transcriptionally through Sp1-binding sites

1999 • 69 citations

Sp1 Binding Plays a Critical Role in Erb-B2- and v-ras-Mediated Downregulation of α₂-Integrin Expression in Human Mammary Epithelial Cells

1996 • 62 citations

Serum Induction of MEF2/RSRF Expression in Vascular Myocytes Is Mediated at the Level of Translation

1995 • 55 citations

Retinoblastoma protein associates with SP1 and activates the hamster dihydrofolate reductase promoter

1998 • 51 citations

Mpl Ligand Enhances the Transcription of the Cyclin D3 Gene: A Potential Role for Sp1 Transcription Factor

1999 • 49 citations

Molecular Mechanisms of Endothelin-1–Induced Cell-Cycle Progression

1999 • 41 citations