Orthotopic and ectopic organ environments differentially influence the sensitivity of murine colon carcinoma cells to doxorubicin and 5‐fluorouracil

Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review.

1989 • 3,308 citations

Acid pH in tumors and its potential for therapeutic exploitation.

1989 • 1,633 citations

Critical factors in the biology of human cancer metastasis: twenty-eighth G.H.A. Clowes memorial award lecture.

1990 • 1,147 citations

Multiple-Drug Resistance in Human Cancer

1987 • 703 citations

Tumor induction relationships in development of transplantable cancers of the colon in mice for chemotherapy assays, with a note on carcinogen structure.

1975 • 573 citations

Delivery of Novel Therapeutic Agents in Tumors: Physiological Barriers and Strategies

1989 • 571 citations

Influence of organ environment on the growth, selection, and metastasis of human colon carcinoma cells in nude mice.

1988 • 462 citations

Promoting effect of bile acids in colon carcinogenesis in germ-free and conventional F344 rats.

1977 • 436 citations

Clinical perspective of human colorectal cancer metastasis

1984 • 384 citations

Therapeutic attack of hypoxic cells of solid tumors: presidential address.

1988 • 258 citations

MECHANISMS OF MULTIDRUG RESISTANCE AND IMPLICATIONS FOR THERAPY

1988 • 230 citations

Pharmacokinetics and metabolism of adriamycin in man

1973 • 213 citations

Multifactorial resistance to adriamycin: relationship of DNA repair, glutathione transferase activity, drug efflux, and P-glycoprotein in cloned cell lines of adriamycin-sensitive and -resistant P388 leukemia.

1988 • 196 citations

P-glycoprotein and multidrug resistance in cancer chemotherapy.

1989 • 139 citations

The cellular heterogeneity of malignant neoplasms: implications for adjuvant chemotherapy.

1985 • 121 citations

Biology of the protein kinase C family

1989 • 120 citations

Assessment of P-glycoprotein, glutathione-based detoxifying enzymes and O6-alkylguanine-DNA alkyltransferase as potential indicators of constitutive drug resistance in human colorectal tumors.

1991 • 88 citations

Role of chemotherapy in the treatment of colorectal carcinoma

1987 • 72 citations

The influence of site of metastasis on tumour growth and response to chemotherapy

1975 • 65 citations

Development of an animal model to study the biology of recurrent colorectal cancer originating from mesenteric lymph system metastases

1989 • 56 citations

Mechanisms of combined effects of gamma-interferon and 5-fluorouracil on human colon cancers implanted into nude mice.

1989 • 40 citations

Site-dependent differences in response of the UV-2237 murine fibrosarcoma to systemic therapy with adriamycin.

1990 • 38 citations

Pharmacokinetics of 5-fluorouracil infusions in the rat: Comparison with man and other species

1985 • 25 citations

Differential efficacy of flavone acetic acid against liver versus lung metastases in a human tumour xenograft

1991 • 24 citations

Differences in chemosensitivity between subcutaneous and pulmonary tumours

1985 • 21 citations

Pharmacologic assessment of regimen chemosensitivity in the soft-agar assay: Effect of oxygen on human tumors

1985 • 4 citations