Disturbances in Leptin Metabolism Are Related to Energy Imbalance during Acute Exacerbations of Chronic Obstructive Pulmonary Disease

New methods for calculating metabolic rate with special reference to protein metabolism

1949 • 5,356 citations

Standards for the Diagnosis and Care of Patients with Chronic Obstructive Pulmonary Disease

1995 • 3,549 citations

Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.

1995 • 3,454 citations

Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression

1998 • 2,143 citations

Outcomes following acute exacerbation of severe chronic obstructive lung disease. The SUPPORT investigators (Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatments)

1996 • 1,390 citations

Weight Loss Is a Reversible Factor in the Prognosis of Chronic Obstructive Pulmonary Disease

1998 • 1,085 citations

Effect of Systemic Glucocorticoids on Exacerbations of Chronic Obstructive Pulmonary Disease

1999 • 864 citations

Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters.

1996 • 864 citations

Multiple Cytokines and Acute Inflammation Raise Mouse Leptin Levels: Potential Role in Inflammatory Anorexia

1997 • 798 citations

The expression of TNF alpha by human muscle. Relationship to insulin resistance.

1996 • 727 citations

Statistical guidelines for contributors to medical journals.

1983 • 648 citations

Effects of inhaled and oral glucocorticoids on inflammatory indices in asthma and COPD.

1997 • 564 citations

Airway eosinophilia in chronic bronchitis during exacerbations.

1994 • 537 citations

Predictive Factors of Hospitalization for Acute Exacerbation in a Series of 64 Patients with Chronic Obstructive Pulmonary Disease

1999 • 526 citations

Evidence for a relation between metabolic derangements and increased levels of inflammatory mediators in a subgroup of patients with chronic obstructive pulmonary disease.

1996 • 526 citations

The OB Protein (Leptin) Pathway - A Link Between Adipose Tissue Mass and Central Neural Networks

1996 • 517 citations

Tumor necrosis factor-alpha levels and weight loss in chronic obstructive pulmonary disease.

1994 • 487 citations

Leptin Prevents Respiratory Depression in Obesity

1999 • 393 citations

Plasma Leptin Levels Are Increased in Survivors of Acute Sepsis: Associated Loss of Diurnal Rhythm in Cortisol and Leptin Secretion

1998 • 393 citations

Elevated TNF-alpha production by peripheral blood monocytes of weight-losing COPD patients.

1996 • 342 citations

The Maastricht Protocol for the Measurement of Body Composition and Energy Expenditure with Labeled Water

1995 • 322 citations

IL-1β mediates leptin induction during inflammation

1998 • 301 citations

Leptin Concentrations in Relation to Body Mass Index and the Tumor Necrosis Factor-α System in Humans¹

1997 • 278 citations

Cachectin/TNF or IL-1 alpha induces cachexia with redistribution of body proteins

1989 • 261 citations

Intraventricular Leptin Reduces Food Intake and Body Weight of Lean Rats but Not Obese Zucker Rats

1996 • 257 citations

Tumor Necrosis Factor Increases Serum Leptin Levels in Humans

1997 • 256 citations

Body composition by bioelectrical-impedance analysis compared with deuterium dilution and skinfold anthropometry in patients with chronic obstructive pulmonary disease

1991 • 251 citations

Plasma Leptin Is Related to Proinflammatory Status and Dietary Intake in Patients with Chronic Obstructive Pulmonary Disease

1999 • 214 citations

Interleukin 1α Increases Serum Leptin Concentrations in Humans

1997 • 203 citations

Characterization of Nonresponse to High Caloric Oral Nutritional Therapy in Depleted Patients with Chronic Obstructive Pulmonary Disease

2000 • 192 citations

Effects of an acute exacerbation on nutritional and metabolic profile of patients with COPD

1997 • 182 citations

Total free living energy expenditure in patients with severe chronic obstructive pulmonary disease.

1997 • 167 citations

Value of C-reactive protein measurements in exacerbations of chronic obstructive pulmonary disease

1998 • 161 citations

Slow release of soluble TNF receptors by monocytes in vitro.

1994 • 150 citations

Robust Leptin Secretory Responses to Dexamethasone in Obese Subjects*

1997 • 142 citations

Prevalence of an elevated resting energy expenditure in patients with chronic obstructive pulmonary disease in relation to body composition and lung function

1998 • 130 citations

Intracerebroventricular Injection of Leptin Increases Thermogenesis and Mobilizes Fat Metabolism inob/obMice

1996 • 124 citations

Leptin and Interleukin-6 in Sepsis

1998 • 113 citations

Plasma Leptin Levels Are Increased in Survivors of Acute Sepsis: Associated Loss of Diurnal Rhythm in Cortisol and Leptin Secretion

1998 • 103 citations

Leptin Concentrations in Relation to Body Mass Index and the Tumor Necrosis Factor- System in Humans

1997 • 94 citations

Tumor Necrosis Factor Increases Serum Leptin Levels in Humans

1997 • 89 citations

Effect of isoprenaline on plasma leptin and lipolysis in humans

1998 • 84 citations

Acute exacerbations in patients with COPD: predictors of need for mechanical ventilation

1996 • 82 citations

Increased plasma concentrations of soluble tumor necrosis factor receptors in sepsis syndrome

1994 • 81 citations

Robust Leptin Secretory Responses to Dexamethasone in Obese Subjects

1997 • 79 citations

Interleukin 1 Increases Serum Leptin Concentrations in Humans

1997 • 68 citations

Effects of Nutritional Status and Aging on Leptin Gene Expression in Mice: Importance of Glucose

1996 • 65 citations

Hyperleptinemia: Relationship to Adiposity and Insulin Resistance in the Spontaneously Obese Rhesus Monkey

1996 • 59 citations

Increased concentrations of cytokines and adhesion molecules in patients after repair of abdominal aortic aneurysm.

1996 • 56 citations

Role of adenosine in insulin-stimulated release of leptin from isolated white adipocytes of Wistar rats.

2000 • 44 citations

Acute and prolonged administration of glucocorticoids (methylprednisolone) does not affect plasma leptin concentration in humans

1997 • 42 citations

Body-water compartments measured by bio-electrical impedance spectroscopy in patients with chronic obstructive pulmonary disease

1998 • 42 citations

Regulation of OB Gene Expression in Rodents and Humans

1996 • 33 citations

The effect of nutritional status on the cytokine and acute phase protein responses to elective surgery

1995 • 32 citations

Insulin receptor/IRS-1/PI 3-kinase signaling system in corticosteroid-induced insulin resistance

1996 • 27 citations