Pharmacological and pharmacodynamic essentials of H2-receptor antagonists and proton pump inhibitors for the practising physician

Definition and Antagonism of Histamine H2-receptors

1972 • 2,284 citations

Progress in Clinical and Biological Research

1979 • 1,317 citations

Omeprazole Compared with Misoprostol for Ulcers Associated with Nonsteroidal Antiinflammatory Drugs

1998 • 874 citations

Speed of healing and symptom relief in grade II to IV gastroesophageal reflux disease: A meta-analysis

1997 • 853 citations

Substituted benzimidazoles inhibit gastric acid secretion by blocking (H+ + K+) ATPase

1981 • 619 citations

A nonelectrogenic H+ pump in plasma membranes of hog stomach.

1976 • 602 citations

Appropriate Acid Suppression for the Management of Gastro-Oesophageal Reflux Disease

1992 • 554 citations

European journal of gastroenterology and hepatology

1990 • 365 citations

Is there an optimal degree of acid suppression for healing of duodenal ulcers?

1990 • 351 citations

Pharmacokinetics, Metabolism and Interactions of Acid Pump Inhibitors

1996 • 332 citations

Nocturnal Recovery of Gastric Acid Secretion With Twice-Daily Dosing of Proton Pump Inhibitors

1998 • 314 citations

Esomeprazole provides improved acid control vs. omeprazole in patients with symptoms of gastro‐oesophageal reflux disease

2000 • 291 citations

Acid suppression in duodenal ulcer: a meta-analysis to define optimal dosing with antisecretory drugs.

1987 • 285 citations

Ranitidine controls nocturnal gastric acid breakthrough on omeprazole: A controlled study in normal subjects

1998 • 285 citations

Omeprazole

1991 • 279 citations

Pantoprazole

1996 • 213 citations

Proton Pump Inhibitors and Acid‐Related Diseases

1997 • 202 citations

Importance of pH Control in the Management of GERD

1999 • 190 citations

Omeprazole: A Study of Its Inhibition of Gastric pH and Oral Pharmacokinetics After Morning or Evening Dosage

1985 • 180 citations

A placebo‐controlled trial to assess the effects of 8 days of dosing with rabeprazole versus omeprazole on 24‐h intragastric acidity and plasma gastrin concentrations in young healthy male subjects

1998 • 179 citations

Effect of Repeated Injection and Continuous Infusion of Omeprazole and Ranitidine on Intragastric Ph Over 72 Hours Figure 1

1999 • 151 citations

Do continuous infusions of omeprazole and ranitidine retain their effect with prolonged dosing?

1994 • 147 citations

Single nocturnal dose of an H2 receptor antagonist for the treatment of duodenal ulcer.

1983 • 140 citations

Efficacy of primed infusions with high dose ranitidine and omeprazole to maintain high intragastric pH in patients with peptic ulcer bleeding: a prospective randomised controlled study.

1997 • 135 citations

Pharmacological aspects of acid secretion

1995 • 131 citations

The continuing development of proton pump inhibitors with particular reference to pantoprazole

1995 • 124 citations

Esomeprazole

2000 • 121 citations

The Effects of Oral Doses of Lansoprazole and Omeprazole on Gastric pH

1997 • 105 citations

Rabeprazole

1998 • 104 citations

Omeprazole

1994 • 102 citations

The relationship between suppression of acidity and gastric ulcer healing rates

1990 • 99 citations

Clinical Pharmacokinetics of Lansoprazole

1995 • 96 citations

Lansoprazole

1997 • 92 citations

Rebound nocturnal hypersecretion after four weeks treatment with an H2 receptor antagonist.

1989 • 86 citations

Comparison of lansoprazole with omeprazole on 24‐hour pH, acid secretion and serum gastrin in healthy volunteers

1994 • 86 citations

Optimizing acid suppression for treatment of acid-related diseases

1995 • 82 citations

Twenty-four-hour intragastric pH: tolerance within 5 days of continuous ranitidine administration

2000 • 81 citations

Pharmacokinetic properties of E3810, a new proton pump inhibitor, in healthy male volunteers.

1994 • 76 citations

Rebound intragastric hyperacidity after abrupt withdrawal of histamine H2 receptor blockade.

1991 • 70 citations

Relationship between Reduction of Gastric Acid Secretion and Plasma Gastrin Concentration during Omeprazole Treatment

1988 • 70 citations

INHIBITION OF NOCTURNAL ACID SECRETION IN DUODENAL ULCER BY ONE ORAL DOSE OF METIAMIDE

1974 • 62 citations

Omeprazole (20 mg) daily given in the morning or evening: a comparison of effects on gastric acidity, and plasma gastrin and omeprazole concentration

1992 • 61 citations

Nocturnal intragastric acidity during and after a period of dosing with either ranitidine or omeprazole

1991 • 60 citations

Effects of oral rabeprazole on oesophageal and gastric pH in patients with gastro‐oesophageal reflux disease

1997 • 57 citations

Effect of food on H2-receptor blockade in normal subjects and duodenal ulcer patients.

1990 • 55 citations

Lansoprazole versus omeprazole: influence on meal‐stimulated gastric acid secretion

1997 • 54 citations

Effect of omeprazole on the secretion of intrinsic factor, gastric acid and pepsin in man.

1985 • 50 citations

Intragastric pH and serum gastrin during administration of different doses of pantoprazole in healthy subjects.

1996 • 49 citations

Esomeprazole (E) 40 mg provides more effective acid control than pantoprazole (P) 40 mg

2000 • 48 citations

Time to maximum effect of lansoprazole on gastric pH in normal male volunteers

1996 • 48 citations

Marked rebound acid hypersecretion after treatment with ranitidine.

1996 • 47 citations

Pharmacokinetics and absolute bioavailability of lansoprazole

1996 • 45 citations

Human gastric acid secretion following repeated doses of AG‐1749

1989 • 45 citations

Lansoprazole and omeprazole in the treatment of acid peptic disorders

1996 • 45 citations

Effect of no treatment, cimetidine 1 g/day, cimetidine 2 g/day and cimetidine combined with atropine on nocturnal gastric secretion in cimetidine non-responders.

1984 • 41 citations

Pantoprazole, a new proton-pump inhibitor, has a precise and predictable profile of activity

1996 • 39 citations

Effect of repeated injection and continuous infusion of omeprazole and ranitidine on intragastric pH over 72 hours

1999 • 39 citations

Lansoprazole: A Comprehensive Review

1997 • 38 citations

On‐demand treatment of gastro‐oesophageal reflux symptoms: a comparison of ranitidine 75 mg with cimetidine 200 mg or placebo

1998 • 38 citations

Dose–response relationship of lansoprazole to gastric acid antisecretory effects

1998 • 38 citations

Comparison of Ranitidine and Cimetidine Ulcer Maintenance Therapy

1987 • 38 citations

Rabeprazole produces rapid, potent, and long‐acting inhibition of gastric acid secretion in subjects with Helicobacter pylori infection

2000 • 38 citations

Rebound hypersecretion after H2-antagonist withdrawal-a comparative study with nizatidine, ranitidine and famotidine

1991 • 36 citations

Comparison of 24‐h control of gastric acidity by three different dosages of pantoprazole in patients with duodenal ulcer

1998 • 36 citations

Twenty-four-hour monitoring of intragastric acidity: comparison between lansoprazole 30mg and pantoprazole 40mg

1997 • 34 citations

Comparison of the Effect of Lansoprazole and Omeprazole on Intragastric Acidity and Gastroesophageal Reflux in Patients with Gastroesophageal Reflux Disease

1998 • 32 citations

Effect of Ranitidine on Meal-Induced Gastric Pepsin and Acid Secretion and the Influence of Adding Ethanol to the Meal

1986 • 32 citations

Specific proton pump inhibitors E3810 and lansoprazole affect the recovery process of gastric secretion in rats differently

1994 • 32 citations

Comparison of the effect of the antacid Rennie versus low‐dose H₂‐receptor antagonists (ranitidine, famotidine) on intragastric acidity

1998 • 31 citations

Effect of pantoprazole on 24‐h intragastric pH and serum gastrin in humans.

1994 • 31 citations

Treatment of reflux oesophagitis of moderate and severe grade with ranitidine or pantoprazole—comparison of 24‐hour intragastric and oesophageal pH

1997 • 30 citations

Morning and evening administration of pantoprazole: a study to compare the effect on 24-hour intragastric pH

1997 • 28 citations

Gastro-Oesophageal Reflux during 3 Months of Therapy with Ranitidine in Reflux Oesophagitis

1996 • 28 citations

Low‐dose ranitidine for the relief of heartburn

1999 • 27 citations

Comparison of the effects of over-the-counter famotidine and calcium carbonate antacid on postprandial gastric acid. A randomized controlled trial.

1996 • 27 citations

Effects of oral pantoprazole on 24‐hour intragastric acidity and plasma gastrin profiles

1992 • 27 citations

Effect of four lansoprazole dose levels and one dosage regimen of omeprazole on 24-hour intragastric pH in healthy subjects.

1995 • 24 citations

Antisecretory effect and oral pharmacokinetics following low dose omeprazole in man.

1985 • 23 citations

Influence of Lansoprazole on Intragastric 24-Hour pH, Meal-Stimulated Gastric Acid Secretion, and Concentrations of Gastrointestinal Hormones and Enzymes in Serum and Gastric Juice in Healthy Volunteers

1995 • 21 citations

Esomeprazole 40 mg provides more effective acid control than lansoprazole 30 mg

2000 • 21 citations

Up-regulation of H2 receptor and adenylate cyclase in rabbit parietal cells during prolonged treatment with H2-receptor antagonists.

1999 • 21 citations

The effects of oral rabeprazole on endocrine and gastric secretory function in healthy volunteers

1999 • 20 citations

Inhibition of intragastric acidity in healthy subjects dosed with ranitidine 75 mg: a comparative study with cimetidine and placebo

1997 • 17 citations

Comparison of the Effects of Over-the-counter Famotidine and Calcium Carbonate Antacid on Postprandial Gastric Acid

1996 • 16 citations

Inhibitory action of E3810 on H+, K+-ATPase and gastric acid secretion in vitro.

1993 • 15 citations

The effects of low doses of ranitidine on intragastric acidity in healthy men

1998 • 14 citations

Initial potency of lansoprazole and omeprazole tablets on pentagastrin‐stimulated gastric acid secretion—a placebo‐controlled study in healthy volunteers

2000 • 11 citations

Dose ranging study of lansoprazole, a new proton pump inhibitor, in patients with high gastric acid secretion

1992 • 10 citations

Nocturnal intragastric acidity after over‐the‐counter doses of famotidine, ranitidine or placebo

1997 • 10 citations

A double-blind randomized study comparing different dose regimens of H2-receptor antagonists on 24-hour gastric secretion in normal subjects and duodenal ulcer patients.

1987 • 10 citations

A double-blind randomized study comparing different dose regimens of H2-receptor antagonists on 24-hour gastric secretion in normal subjects and duodenal ulcer patients.

1987 • 7 citations

Impact of food intake on the antisecretory effect of low‐dose ranitidine and famotidine

1999 • 4 citations

The effect of H2-receptor antagonists on pepsin secretion in man.

1985 • 3 citations