Intracellular polymerization of sickle hemoglobin. Effects of cell heterogeneity.

Separation of erythrocytes according to age on a simplified density gradient.

1974 • 252 citations

5-Azacytidine increases gamma-globin synthesis and reduces the proportion of dense cells in patients with sickle cell anemia

1983 • 248 citations

Kinetic studies on photolysis-induced gelation of sickle cell hemoglobin suggest a new mechanism

1980 • 234 citations

The intracellular polymerization of sickle hemoglobin and its relevance to sickle cell disease

1981 • 216 citations

Erythrocyte Hb-S Concentration AN IMPORTANT FACTOR IN THE LOW OXYGEN AFFINITY OF BLOOD IN SICKLE CELL ANEMIA

1973 • 182 citations

Deformability of oxygenated irreversibly sickled cells.

1980 • 170 citations

A new density gradient system for the separation of human red blood cells

1980 • 152 citations

Gelation of sickle cell hemoglobin in mixtures with normal adult and fetal hemoglobins

1979 • 141 citations

Oxygen binding by sickle cell hemoglobin polymers

1982 • 113 citations

Molecular and cellular pathogenesis of hemoglobin SC disease.

1982 • 109 citations

Kinetics of sickle haemoglobin polymerization in single red cells

1982 • 96 citations

Non-ideality and the thermodynamics of sickle-cell hemoglobin gelation

1977 • 94 citations

Determination of deoxyhemoglobin S polymer in sickle erythrocytes upon deoxygenation.

1980 • 91 citations

F-Cell Production in Sickle Cell Anemia: Regulation by Genes Linked to β-Hemoglobin Locus

1981 • 68 citations

Ligand binding and the gelation of sickle cell hemoglobin

1979 • 66 citations

SC erythrocytes have an abnormally high intracellular hemoglobin concentration. Pathophysiological consequences.

1982 • 64 citations

Minor hemoglobins in sickle cell anemia, β-thalassemia, and related conditions: A study of red cell fractions isolated by density gradient centrifugation

1975 • 60 citations

The effect of deoxygenation on red cell density: significance for the pathophysiology of sickle cell anemia

1982 • 57 citations

A simple laboratory alternative to irreversibly sickled cell (ISC) counts

1982 • 46 citations

Kinetics of hemoglobin S gelation followed by continuously sensitive low-shear viscosity

1977 • 46 citations

Polymerization of hemoglobin in sickle trait erythrocytes and lysates.

1981 • 41 citations

Ligand-linked phase equilibria of sickle cell hemoglobin

1980 • 32 citations

The effect of erythrocyte membrane preparations on the polymerization of sickle hemoglobin.

1981 • 31 citations

Carbon-13-proton nuclear magnetic double-resonance study of deoxyhemoglobin S gelation

1979 • 31 citations

Stabilization of the shape of sickled cells by calcium and A23187

1976 • 29 citations

Simultaneous determination of hemoglobin derivatives, oxygen content, oxygen capacity, and oxygen saturation in 10 microliters of whole blood.

1977 • 26 citations

The intracellular polymerization of sickle hemoglobin and its relevance to sickle cell disease

1981 • 14 citations

The effect of deoxygenation on red cell density: significance for the pathophysiology of sickle cell anemia

1982 • 9 citations

Relationship of Density Distribution and Pyruvate Kinase Electrophoretic Pattern of Erythrocytes in Sickle Cell Diseases and Other Disorders

1978 • 8 citations

Stabilization of the shape of sickled cells by calcium and A23187

1976 • 5 citations

A simple laboratory alternative to irreversibly sickled cell (ISC) counts

1982 • 4 citations

LIGAND BINDING AND THE GELATION OF SICKLE CELL HEMOGLOBIN

1978 • 3 citations