Oxidized Lipid-Driven Chemokine Receptor Switch, CCR2 to CX3CR1, Mediates Adhesion of Human Macrophages to Coronary Artery Smooth Muscle Cells Through a Peroxisome Proliferator-Activated Receptor γ–Dependent Pathway

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

2001 • 156,143 citations

Atherosclerosis — An Inflammatory Disease

1999 • 21,494 citations

Blood Monocytes Consist of Two Principal Subsets with Distinct Migratory Properties

2003 • 3,265 citations

A new class of membrane-bound chemokine with a CX3C motif

1997 • 1,964 citations

Decreased lesion formation in CCR2−/− mice reveals a role for chemokines in the initiation of atherosclerosis

1998 • 1,943 citations

Oxidized LDL Regulates Macrophage Gene Expression through Ligand Activation of PPARγ

1998 • 1,819 citations

PPARγ Promotes Monocyte/Macrophage Differentiation and Uptake of Oxidized LDL

1998 • 1,771 citations

Identification and Molecular Characterization of Fractalkine Receptor CX3CR1, which Mediates Both Leukocyte Migration and Adhesion

1997 • 1,406 citations

CD36 is a receptor for oxidized low density lipoprotein

1993 • 1,271 citations

Structural Identification by Mass Spectrometry of Oxidized Phospholipids in Minimally Oxidized Low Density Lipoprotein That Induce Monocyte/Endothelial Interactions and Evidence for Their Presence in Vivo

1997 • 751 citations

A definition of initial, fatty streak, and intermediate lesions of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association.

1994 • 715 citations

The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion

2003 • 686 citations

Fractalkine and CX3CR1 Mediate a Novel Mechanism of Leukocyte Capture, Firm Adhesion, and Activation under Physiologic Flow

1998 • 679 citations

MCP-1 deficiency reduces susceptibility to atherosclerosis in mice that overexpress human apolipoprotein B

1999 • 665 citations

Tumor Necrosis Factor-α-converting Enzyme (ADAM17) Mediates the Cleavage and Shedding of Fractalkine (CX3CL1)

2001 • 623 citations

Fractalkine Preferentially Mediates Arrest and Migration of CD16+ Monocytes

2003 • 563 citations

A leukocyte homologue of the IL-8 receptor CXCR-2 mediates the accumulation of macrophages in atherosclerotic lesions of LDL receptor-deficient mice.

1998 • 525 citations

Decreased Atherosclerotic Lesion Formation in CX3CR1/Apolipoprotein E Double Knockout Mice

2003 • 465 citations

Decreased atherosclerosis in CX3CR1–/– mice reveals a role for fractalkine in atherogenesis

2003 • 460 citations

Polymorphism in the fractalkine receptor CX3CR1 as a genetic risk factor for coronary artery disease

2001 • 348 citations

STUDIES ON THE ROLE OF LIPOPEROXIDES IN HUMAN PATHOLOGY

1952 • 347 citations

CD14+CD16+ monocytes in coronary artery disease and their relationship to serum TNF-α levels

2004 • 287 citations

Chemokine receptor mutant CX3CR1-M280 has impaired adhesive function and correlates with protection from cardiovascular disease in humans

2003 • 267 citations

Peroxisome Proliferator-Activated Receptor-γ Calls for Activation in Moderation: Lessons from Genetics and Pharmacology

2004 • 255 citations

CX3C-Chemokine, Fractalkine-Enhanced Adhesion of THP-1 Cells to Endothelial Cells Through Integrin-Dependent and -Independent Mechanisms

2000 • 227 citations

Human Monocytes/Macrophages Release TNF-α in Response to Ox-LDL

1996 • 211 citations

Oxidized LDL reduces monocyte CCR2 expression through pathways involving peroxisome proliferator–activated receptor γ

2000 • 172 citations

Loss of CCR2 Expression and Functional Response to Monocyte Chemotactic Protein (MCP-1) During the Differentiation of Human Monocytes: Role of Secreted MCP-1 in the Regulation of the Chemotactic Response

1999 • 166 citations

Induction of interleukin 1 beta expression from human peripheral blood monocyte-derived macrophages by 9-hydroxyoctadecadienoic acid.

1992 • 158 citations

Smooth Muscle Cells in Human Atherosclerotic Plaques Express the Fractalkine Receptor CX ₃ CR1 and Undergo Chemotaxis to the CX ₃ C Chemokine Fractalkine (CX ₃ CL1)

2003 • 151 citations

Characterization of fractalkine (CX3CL1) and CX3CR1 in human coronary arteries with native atherosclerosis, diabetes mellitus, and transplant vascular disease

2002 • 151 citations

Fractalkine Is Expressed by Smooth Muscle Cells in Response to IFN-γ and TNF-α and Is Modulated by Metalloproteinase Activity

2002 • 146 citations

Peroxisome proliferator-activated receptor γ C161→T polymorphism and coronary artery disease

1999 • 130 citations

Strong increase in hydroxy fatty acids derived from linoleic acid in human low density lipoproteins of atherosclerotic patients

1998 • 128 citations

Expression of the monocyte chemoattractant protein-1 receptor CCR2 is increased in hypercholesterolemia: differential effects of plasma lipoproteins on monocyte function

1999 • 112 citations

Alanine for Proline Substitution in the Peroxisome Proliferator–Activated Receptor Gamma-2 (PPARG2) Gene and the Risk of Incident Myocardial Infarction

2003 • 103 citations

Lipids of human atheroma. 8. Oxidised derivatives of cholesteryl linoleate.

1973 • 95 citations

Lipids of human atheroma

1973 • 62 citations

OxLDL upregulates CXCR2 expression in monocytes via scavenger receptors and activation of p38 mitogen-activated protein kinase

2002 • 59 citations

CXC-chemokines in coronary artery disease: possible pathogenic role of interactions between oxidized low-density lipoprotein, platelets and peripheral blood mononuclear cells

2003 • 44 citations

Cloning and functional characterization of the human fractalkine receptor promoter regions

2002 • 32 citations

Genomic Organization and Evolution of the CX3CR1/CCR8 Chemokine Receptor Locus

2003 • 26 citations

The occurrence of peroxidized lipids in atheromatous human aortas

1951 • 21 citations