Internal perfusion of guinea‐pig hepatocytes with buffered Ca²⁺ or inositol 1,4,5‐trisphosphate mimics noradrenaline activation of K⁺ and Cl⁻ conductances

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures

1980 • 2,218 citations

Tight-Seal Whole-Cell Recording

1983 • 605 citations

The second messenger linking receptor activation to internal Ca release in liver

1984 • 557 citations

Changes in free cytosolic Ca2+ in hepatocytes following alpha 1-adrenergic stimulation. Studies on Quin-2-loaded hepatocytes.

1983 • 375 citations

Apamin blocks certain neurotransmitter-induced increases in potassium permeability

1979 • 356 citations

Effects of quinine and apamin on the calcium‐dependent potassium permeability of mammalian hepatocytes and red cells.

1981 • 298 citations

Agonist-induced oscillations in cytoplasmic free calcium concentration in single rat hepatocytes

1987 • 271 citations

Inositol 1,4,5-trisphosphate and inositol 1,3,4-trisphosphate formation in Ca2+-mobilizing-hormone-activated cells

1985 • 234 citations

Actions of inositol phosphates on Ca2+ pools in guinea-pig hepatocytes

1984 • 158 citations

Incorporation of calcium buffers into salamander retinal rods: a rejection of the calcium hypothesis of phototransduction.

1986 • 150 citations

Changes in intracellular calcium and in membrane currents evoked by injection of inositol trisphosphate into Xenopus oocytes

1986 • 123 citations

Effects of noradrenaline on potassium efflux, membrane potential and electrolyte levels in tissue slices prepared from guinea‐pig liver

1972 • 90 citations

Potentiation of muscarinic and alpha-adrenergic responses by an analogue of guanosine 5'-triphosphate.

1986 • 83 citations

Pharmacology of adrenoceptors

1985 • 68 citations

Solubilization of phospholipids by chaotropic ion solutions.

1983 • 26 citations