Advances in the Treatment of Acute Myelogenous Leukemia

Proposals for the Classification of the Acute Leukaemias F<scp>rench</scp>‐A<scp>merican</scp>‐B<scp>ritish</scp> (FAB) C<scp>o‐operative</scp> G<scp>roup</scp>

1976 • 5,620 citations

Quantitative Relationships Between Circulating Leukocytes and Infection in Patients with Acute Leukemia

1966 • 2,470 citations

Bone-Marrow Transplantation

1975 • 1,667 citations

The Importance of Beta, the Type II Error and Sample Size in the Design and Interpretation of the Randomized Control Trial

1978 • 1,634 citations

Terminal differentiation of human promyelocytic leukemia cells induced by dimethyl sulfoxide and other polar compounds.

1978 • 1,624 citations

One hundred patients with acute leukemia treated by chemotherapy, total body irradiation, and allogeneic marrow transplantation

1977 • 953 citations

Variation of the supercoils in closed circular DNA by binding of antibiotics and drugs: Evidence for molecular models involving intercalation

1970 • 780 citations

Control of normal cell differentiation and the phenotypic reversion of malignancy in myeloid leukaemia

1978 • 593 citations

Arabinosyl Cytosine: A Useful Agent in the Treatment of Acute Leukemia in Adults

1968 • 559 citations

Acute Myelogenous Leukemia: A Human Cell Line Responsive to Colony-Stimulating Activity

1978 • 537 citations

Acute Leukemia after Alkylating-Agent Therapy of Ovarian Cancer

1977 • 453 citations

Clinical and pharmacological studies with cis-diamminedichloroplatinum (II).

1973 • 430 citations

Effect of ethanol on liver 8-aminolaevulinate synthetase in rats.

1968 • 430 citations

Cis-diamminedichloroplatinum (II)

1977 • 424 citations

Clinical Evaluation of a New Antimetabolite, 6-Mercaptopurine, in the Treatment of Leukemia and Allied Diseases

1953 • 379 citations

Chromosomal banding patterns in acute nonlymphocytic leukemia

1976 • 351 citations

Successful Granulocyte Transfusion Therapy for Gram-Negative Septicemia

1977 • 328 citations

Infection Prevention in Acute Nonlymphocytic Leukemia

1975 • 327 citations

Protected Environments and Prophylactic Antibiotics

1973 • 323 citations

The Effectiveness of Combinations of Antileukemic Agents in Inducing and Maintaining Remission in Children with Acute Leukemia

1965 • 314 citations

Agar Culture Studies in 127 Cases of Untreated Acute Leukemia: The Prognostic Value of Reclassification of Leukemia According to In Vitro Growth Characteristics

1974 • 303 citations

A Randomized Clinical Trial of Granulocyte Transfusions for Infection in Acute Leukemia

1977 • 298 citations

Hematologic malignancies and other marrow failure states: progress in the management of complicating infections.

1974 • 296 citations

Classification of Acute Leukemia

1977 • 282 citations

Filtration Leukapheresis for Granulocyte Transfusion Therapy

1975 • 252 citations

Preleukemia

1973 • 243 citations

Treatment of acute leukemia in adults

1975 • 239 citations

Acute nonlymphocytic leukemia.A delayed complication of Hodgkin's disease therapy: Analysis of 109 cases

1977 • 227 citations

HIGH REMISSION-INDUCTION RATE IN ACUTE MYELOID LEUKÆMIA

1977 • 218 citations

Studies of Sequential and Combination Antimetabolite Therapy in Acute Leukemia: 6-Mercaptopurine and Methotrexate

1961 • 218 citations

Immunotherapy for Acute Myelogenous Leukaemia

1973 • 214 citations

Granulocyte Transfusions for the Prevention of Infection in Patients Receiving Bone-Marrow Transplants

1978 • 213 citations

Treatment of adult acute leukemia with arabinosylcytosine and thioguanine

1969 • 211 citations

Infections in cancer patients

1975 • 209 citations

The preleukemic syndrome (hemopoietic dysplasia)

1978 • 183 citations

Infectious Complications of Neoplastic Disease

1971 • 180 citations

A controlled study of the efficacy of granulocyte transfusions in patients with neutropenia

1977 • 179 citations

5-Azacytidine

1976 • 177 citations

CHEMOIMMUNOTHERAPY OF ADULT ACUTE LEUKÆMIA PROLONGATION OF REMISSION IN MYELOBLASTIC LEUKÆMIA WITH B.C.G.

1974 • 172 citations

Correlation of Clinical Findings with Quinacrine-Banded Chromosomes in 90 Adults with Acute Nonlymphocytic Leukemia

1978 • 170 citations

A controlled study of isolation and endogenous microbial suppression in acute myelocytic leukemia patients

1973 • 169 citations

Further evidence for a non‐random chromosomal abnormality in acute promyelocytic leukemia

1977 • 165 citations

ORAL NON-ABSORBED ANTIBIOTICS PREVENT INFECTION IN ACUTE NON-LYMPHOBLASTIC LEUKqMIA

1977 • 156 citations

The incidence of central nervous system leukemia in adults with acute leukemia

1974 • 154 citations

Management of Adult Acute Myelogenous Leukaemia

1973 • 151 citations

Frozen Autologous Platelet Transfusion for Patients with Leukemia

1978 • 137 citations

Prophylactic heparin therapy in acute promyelocytic leukemia

1978 • 134 citations

GRANULOCYTE TRANSFUSIONS IN TREATMENT OF INFECTIONS IN PATIENTS WITH ACUTE LEUKÆMIA AND APLASTIC ANÆMIA

1975 • 132 citations

RANDOMIZED TRIAL OF PROTECTED ENVIRONMENT — PROPHYLACTIC ANTIBIOTICS IN 145 ADULTS WITH ACUTE LEUKEMIA

1978 • 130 citations

Prognosis of Acute Myeloblastic Leukemia: Chromosomal Correlation

1973 • 127 citations

Clinical results of treatment with E. coli L-asparaginase in adults with leukemia, lymphoma, and solid tumors

1970 • 126 citations

THE NATURAL HISTORY OF UNTREATED ACUTE LEUKEMIA

1954 • 121 citations

PROLONGING REMISSION IN MYELOBLASTIC LEUKÆMIA BY TICE-STRAIN BACILLUS CALMETTE-GUÉRIN

1974 • 118 citations

The Clinical Pharmacology of Antineoplastic Agents

1975 • 117 citations

BONE-MARROW TRANSPLANTATION IN ACUTE LEUKÆMIA

1977 • 116 citations

Prognostic significance of pretreatment proliferative activity in adult acute leukemia

1977 • 115 citations

Daunorubicin in the therapy of acute granulocytic leukemia.

1973 • 108 citations

Prophylactic heparin therapy in acute promyelocytic leukemia

1978 • 104 citations

A simplified in vitro classification for prognosis in adult acute leukemia: the application of in vitro results in remission-predictive models

1976 • 103 citations

Acute nonlymphocytic leukemia in adults: correlations with Q-banded chromosomes

1976 • 102 citations

Bone-Marrow Transplantation for Hematologic Neoplasia in 16 Patients with Identical Twins

1974 • 102 citations

Immunotherapy for acute myelogenous leukaemia: a controlled clinical study 2 1/2 years after entry of the last patient

1977 • 101 citations

CO-TRIMOXAZOLE FOR PREVENTION OF INFECTION IN ACUTE LEUKÆMIA

1978 • 98 citations

L-Asparaginase

1970 • 96 citations

Therapy of acute myelogenous leukemia

1978 • 93 citations

THE ROYAL COMMISSION

1968 • 90 citations

Remission maintenance therapy in acute myelogenous leukemia.

1977 • 89 citations

5-Azacytidine (NSC 102816): a new drug for the treatment of myeloblastic leukemia

1976 • 89 citations

Epipodophyllotoxin VP 16213 in Treatment of Acute Leukaemia--Haematosarcoma and Solid Tumours

1973 • 88 citations

Neurological Complications of Acute Leukemia in Adults: Changing Rate

1973 • 88 citations

Human Preleukemia

1973 • 87 citations

Comparative study of cytosine arabinoside therapy alone and combined with thioguanine, mercaptopurine, or daunorubicin in acute myelocytic leukemia

1975 • 85 citations

POMP combination chemotherapy of adult acute leukemia

1973 • 83 citations

Non‐random chromosome changes in acute myeloid leukemia. Chromosome banding examination of 30 cases at diagnosis

1976 • 82 citations

Immunotherapy of cancer : present status of trials in man

1978 • 82 citations

A simplified in vitro classification for prognosis in adult acute leukemia: the application of in vitro results in remission-predictive models

1976 • 80 citations

Acute Myelocytic Leukemia

1976 • 79 citations

Marrow culture studies in adult acute leukemia at presentation and during remission

1977 • 78 citations

The preleukemic syndrome.

1974 • 75 citations

QUALITY AND QUANTITY OF SURVIVAL IN ACUTE MYELOID LEUKÆMIA

1975 • 72 citations

The role of vincristine in the treatment of childhood acute leukemia

1966 • 72 citations

Late Intensification Therapy for Acute Leukemia in Remission

1976 • 70 citations

Predinsome therapy of acute childhood leukemia: Prognosis and duration of response in 330 treated patients

1967 • 69 citations

Chemotherapy of Acute Leukemia

1974 • 67 citations

Prolonged infusion of arabinosyl cytosine in childhood leukemia

1970 • 65 citations

A randomized clinical trial of daunorubicin and a combination of prednisone, vincristine, 6-mercaptopurine, and methotrexate in adult acute nonlymphocytic leukemia.

1972 • 65 citations

Progress in the Treatment of Adults With Acute Leukemia

1976 • 64 citations

PROLONGED MAINTAINED REMISSIONS OF ADULT ACUTE NON-LYMPHOCYTIC LEUKAEMIA

1977 • 63 citations

Treatment of Acute Myeloid Leukaemia with Daunorubicin, Cytosine Arabinoside, Mercaptopurine, L‐Asparaginase, Prednisone and Thioguanine: Results of Treatment with Five Multiple‐Drug Schedules

1974 • 60 citations

AUTOLOGOUS BONE MARROW TRANSPLANTATION IN PATIENTS WITH ADULT ACUTE LEUKEMIA IN RELAPSE

1978 • 60 citations

Pretreatment cytokinetic studies in 94 children with acute leukemia. Relationship to other variables at diagnosis and to outcome of standard treatment

1977 • 58 citations

Clinical study of rubidazone (22 050 R.P.), a new daunorubicin-derived compound, in 170 patients with acute leukemias and other malignancies

1976 • 56 citations

VP 16-213 in acute myelogenous leukaemia

1976 • 55 citations

Immunobiology of bone marrow transplantation.

1978 • 52 citations

Adult acute leukemia.Frequency of central nervous system involvement in long term survivors

1977 • 51 citations

Cell Kinetics and Practical Consequences for Therapy of Acute Leukemia

1975 • 51 citations

A comparative clinical trial of 5-azacytidine and guanazole in previously treated adults with acute nonlymphocytic leukemia

1976 • 49 citations

Cellular maturation in human preleukemia

1978 • 47 citations

Manipulation of the Mitotic Cycle in the Treatment of Acute Myelogenous Leukaemia

1976 • 47 citations

Combination chemotherapy with cytosine arabinoside and rubidomycin in 30 cases of acute granulocytic leukemia

1973 • 46 citations

Treatment of Acute Leukemia

1968 • 44 citations

Cytarabine for Acute Leukemia in Adults

1974 • 44 citations

Relevance of the Cytogenetic Status in Acute Leukemia in Adults2

1973 • 43 citations

Acute Promyelocytic Leukemia

1978 • 43 citations

Cellular maturation in human preleukemia

1978 • 42 citations

"Preleukemia"

1973 • 40 citations

Reverse Transcriptase in Leukocytes of Leukemic Patients in Remission

1976 • 40 citations

MAINTENANCE OF REMISSION IN ACUTE MYELOGENOUS LEUKÆMIA BY A MIXTURE OF B.C.G. AND IRRADIATED LEUKÆMIA CELLS

1977 • 38 citations

The Immunotherapy of Acute Myelogenous Leukaemia using Intravenous BCG

1977 • 38 citations

VINCRISTINE IN THE TREATMENT OF ACUTE LEUKEMIA IN CHILDREN

1966 • 38 citations

Prolonged remission maintenance in acute myeloid leukaemia.

1977 • 37 citations

Immunotherapy of Cancer

1977 • 37 citations

Divergent patterns of marrow cell suspension culture growth in the myeloid leukemias: correlation of in vitro findings with clinical features

1977 • 36 citations

A new observation in the clinical spectrums of erythroleukemia

1978 • 35 citations

A phase 1 and 2 trial of rubidazone in patients with acute leukemia.

1977 • 32 citations

Intensive Multiunit Plateletpheresis of Normal Donors

1974 • 31 citations

Randomized clinical trial of cystosine arabinoside and 6-thioguanine in remission induction and consolidation of adult nonlymphocytic acute leukemia

1977 • 29 citations

Comparison of methotrexate with 6-mercaptopurine–prednisone in treatment of acute leukemia in adults

1967 • 26 citations

SOME ASPECTS OF RECENT ADVANCES IN THE USE OF BLOOD CELL COMPONENTS

1978 • 24 citations

Treatment of Acute Leukaemia in Adults: Comparison of Steroid and Mercaptopurine Therapy, Alone and in Conjunction

1966 • 23 citations

IMMUNOTHERAPY IN THE MANAGEMENT OF ACUTE LEUKAEMIA

1976 • 23 citations

Treatment of Acute Myeloid Leukaemia with Cytosine Arabinoside and Daunomycin in Combination

1972 • 18 citations

Cost analysis of leukemia treatment. A problem-oriented approach

1976 • 16 citations

Immunotherapy in the Management of Myelogenous Leukemia

1976 • 14 citations

Acute granulocytic leukemia: treatment of the disease

1976 • 13 citations

Clinical studies of β‐thioguanine deoxyriboside alone and in combination with arabinosyl cytosine

1976 • 3 citations