Directed evolution of an esterase: screening of enzyme libraries based on ph-Indicators and a growth assay

Quantitative analyses of biochemical kinetic resolutions of enantiomers

1982 • 2,569 citations

Lipases: Interfacial Enzymes with Attractive Applications

1998 • 1,174 citations

ENZYMES IN SYNTHETIC ORGANIC CHEMISTRY

2010 • 753 citations

Design by Directed Evolution

1998 • 668 citations

Directed evolution of a para-nitrobenzyl esterase for aqueous-organic solvents

1996 • 419 citations

Creation of Enantioselective Biocatalysts for Organic Chemistry by In Vitro Evolution

1997 • 372 citations

Directed evolution of enzyme catalysts

1997 • 370 citations

Biotransformations in Organic Chemistry

1997 • 349 citations

Chemical Biology of Epothilones

1998 • 324 citations

Enzymes in synthetic organic chemistry

1995 • 289 citations

Directed evolution of an esterase for the stereoselective resolution of a key intermediate in the synthesis of epothilones

1998 • 145 citations

The metal-ion-free oxidoreductase from Streptomyces aureofaciens has an α/β hydrolase fold

1994 • 116 citations

Characterization and enantioselectivity of a recombinant esterase from Pseudomonas fluorescens

1998 • 82 citations

Artificial evolution by DNA shuffling

1998 • 78 citations

Factors affecting the lipase catalyzed transesterification reactions of 3-hydroxy esters in organic solvents.

1993 • 74 citations

An Efficient Random Mutagenesis Technique Using an E. coli Mutator Strain

2003 • 69 citations

Searching Sequence Space

1995 • 65 citations

A bacterial esterase is homologous with nonhaem haloperoxidases and displays brominating activity

1995 • 61 citations

Enantioselectivity of a recombinant esterase from Pseudomonas fluorescens towards alcohols and carboxylic acids

1998 • 47 citations

Directed Evolution of Enzymes

1998 • 45 citations

Directed Evolution of Enzymes

1998 • 45 citations

A chemoenzymatic synthesis of optically-active dihydropyridines

1991 • 39 citations

Acyloxymethyl as an activating group in lipase-catalyzed enantioselective hydrolysis. A versatile approach to chiral 4-aryl-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylates.

1991 • 35 citations

Epothilones: Promising Natural Products with Taxol‐Like Activity

1997 • 35 citations

Chemoenzymatic route to β-blockers via 3-hydroxy esters

1996 • 31 citations