Cellular adhesion, invasion and metastasis

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule

1984 • 3,580 citations

JUNCTIONAL COMPLEXES IN VARIOUS EPITHELIA

1963 • 3,559 citations

Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate

1983 • 2,596 citations

Transforming gene product of Rous sarcoma virus phosphorylates tyrosine

1980 • 2,387 citations

Laminin–a glycoprotein from basement membranes.

1979 • 2,372 citations

Carbohydrate-Specific Receptors of the Liver

1982 • 1,895 citations

CELLULAR ONCOGENES AND RETROVIRUSES

1983 • 1,671 citations

A cell-surface molecule involved in organ-specific homing of lymphocytes

1983 • 1,515 citations

Structure and Function of Intercellular Junctions

1974 • 1,339 citations

Fibronectins: multifunctional modular glycoproteins.

1982 • 1,334 citations

Cell Adhesion Molecules

1983 • 1,017 citations

Calmodulin

1980 • 982 citations

Tumor invasion and the extracellular matrix.

1983 • 960 citations

The locomotion of fibroblasts in culture

1971 • 955 citations

Immunocytological and biochemical characterization of a new neuronal cell surface component (L1 antigen) which is involved in cell adhesion.

1984 • 739 citations

Role of laminin in the attachment of PAM 212 (epithelial) cells to basement membrane collagen

1980 • 661 citations

Interaction of cytoskeletal proteins on the human erythrocyte membrane

1981 • 606 citations

Vinculin: A cytoskeletal target of the transforming protein of rous sarcoma virus

1981 • 591 citations

Biological behavior of malignant melanoma cells correlated to their survival in vivo.

1975 • 586 citations

Cancer metastasis

1982 • 567 citations

Rapid breakdown of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate in rat hepatocytes stimulated by vasopressin and other Ca2+-mobilizing hormones

1983 • 547 citations

Identity of p36K phosphorylated upon Rous sarcoma virus transformation with a protein purified from brush borders; calcium-dependent binding to non-erythroid spectrin and F-actin.

1984 • 541 citations

Loss of basement membrane components by invasive tumors but not by their benign counterparts.

1983 • 497 citations

Modulator protein as a component of the myosin light chain kinase from chicken gizzard

1978 • 488 citations

Principles of Cell Motility: The Direction of Cell Movement and Cancer Invasion

1965 • 488 citations

L1 mono- and polyclonal antibodies modify cell migration in early postnatal mouse cerebellum

1983 • 482 citations

Actin-binding proteins—regulators of cell architecture and motility

1982 • 468 citations

Chemical characterization of a neural cell adhesion molecule purified from embryonic brain membranes.

1982 • 445 citations

An interaction between vinculin and talin

1984 • 442 citations

Isolation of a cell surface receptor protein for laminin from murine fibrosarcoma cells.

1983 • 441 citations

Adhesion among neural cells of the chick embryo. II. Purification and characterization of a cell adhesion molecule from neural retina.

1977 • 439 citations

Restoration of normal morphology, adhesion and cytoskeleton in transformed cells by addition of a transformation-sensitive surface protein

1977 • 427 citations

Isolation of a tumor cell laminin receptor

1983 • 426 citations

Rapid mobilization of Ca2+ from rat insulinoma microsomes by inositol-1,4,5-trisphosphate

1984 • 410 citations

Identification and purification of a cell surface glycoprotein mediating intercellular adhesion in embryonic and adult tissue

1983 • 396 citations

Decreased Mutual Adhesiveness, a Property of Cells from Squamous Cell Carcinomas

1944 • 391 citations

DYNAMICS OF ANTIGENIC MEMBRANE SITES RELATING TO CELL AGGREGATION IN DICTYOSTELIUM DISCOIDEUM

1973 • 389 citations

Neural crest cell migration: requirements for exogenous fibronectin and high cell density.

1983 • 388 citations

Immunoelectron microscopic studies of the sites of cell-substratum and cell-cell contacts in cultured fibroblasts.

1982 • 369 citations

Adhesion among neural cells of the chick embryo. I. An immunological assay for molecules involved in cell-cell binding.

1977 • 356 citations

Adult and embryonic mouse neural cell adhesion molecules have different binding properties

1983 • 350 citations

Cell shape and membrane changes in the eight-cell mouse embryo: Prerequisites for morphogenesis of the blastocyst

1975 • 340 citations

Cell-cell interactions in early embryogenesis: A molecular approach to the role of calcium

1981 • 338 citations

Role of laminin in the attachment and metastasis of murine tumor cells.

1982 • 334 citations

Differences in the carbohydrate structures of neural cell-adhesion molecules from adult and embryonic chicken brains.

1982 • 311 citations

A monoclonal antibody detaches embryonic skeletal muscle from extracellular matrices.

1982 • 310 citations

Formation of cell-to-substrate contacts during fibroblast motility: An interference-reflexion study

1980 • 307 citations

Interactions of actin, myosin, and a new actin-binding protein of rabbit pulmonary macrophages. II. Role in cytoplasmic movement and phagocytosis.

1976 • 289 citations

Surface Components and Cell Recognition

1979 • 280 citations

Basement membrane changes in breast cancer detected by immunohistochemical staining for laminin.

1981 • 271 citations

Cell surface molecules and tumor metastasis

1984 • 262 citations

N,N-dimethylformamide-induced alteration of cell culture characteristics and loss of tumorigenicity in cultured human colon carcinoma cells.

1979 • 261 citations

The terminal web. A reevaluation of its structure and function.

1979 • 243 citations

The calcium-dependent cell-cell adhesion system regulates inner cell mass formation and cell surface polarization in early mouse development

1983 • 242 citations

Increased sialic acid density in surface glycoprotein of transformed and malignant cells--a general phenomenon?

1973 • 233 citations

Temporal and spatial regulation of fibronectin in early Xenopus development

1984 • 232 citations

Isolation and properties of beta-galactoside binding lectins of calf heart and lung.

1976 • 228 citations

LFA‐1 and Lyt‐2,3, Molecules Associated with T Lymphocyte‐Mediated Killing; and Mac‐1, an LFA‐1 Homologue Associated with Complement Receptor Function¹

1982 • 223 citations

Substrate adhesion of rat hepatocytes: Mechanism of attachment to collagen substrates

1981 • 221 citations

Surface sialic acid reduces attachment of metastatic tumour cells to collagen type IV and fibronectin

1982 • 215 citations

Metastatic tumor cells adhere preferentially to the extracellular matrix underlying vascular endothelial cells

1980 • 212 citations

Organ specificity of blood-borne tumour metastasis determined by cell adhesion?

1975 • 207 citations

Adhesion, growth, and matrix production by fibroblasts on laminin substrates.

1983 • 199 citations

Neural cell adhesion molecule is on embryonic muscle cells and mediates adhesion to nerve cells in vitro

1982 • 194 citations

Fodrin is the general spectrin-like protein found in most cells whereas spectrin and the TW protein have a restricted distribution

1983 • 191 citations

The removal of extracellular fibronectin from areas of cell-substrate contact

1981 • 191 citations

Neural cell adhesion molecule mediates initial interactions between spinal cord neurons and muscle cells in culture.

1983 • 191 citations

Early changes in the distribution and organization of microfilament proteins during cell transformation

1981 • 188 citations

Metastatic tumor cell attachment and invasion assay utilizing vascular endothelial cell monolayers.

1982 • 187 citations

Non-metastasising variants selected from metastasising melanoma cells

1977 • 174 citations

Proteins associated with cytoplasmic actin

1981 • 169 citations

Fibroblast surface antigen produced but not retained by virus-transformed human cells.

1975 • 167 citations

Intercellular adhesion of rat hepatocytes. Identification of a cell surface glycoprotein involved in the initial adhesion process.

1982 • 167 citations

Concomitant loss of cell surface fibronectin and laminin from transformed rat kidney cells

1981 • 162 citations

Characterization of protease-resistant fragments of laminin mediating attachment and spreading of rat hepatocytes.

1983 • 161 citations

Antibodies to a neural cell adhesion molecule disrupt histogenesis in cultured chick retinae

1980 • 160 citations

Cell-cell interaction and polarity of epithelial cells: Specific perturbation using a monoclonal antibody

1983 • 153 citations

Oncogenes of Spontaneous and Chemically Induced Tumors

1982 • 152 citations

Adhesion among neural cells of the chick embryo. III. Relationship of the surface molecule CAM to cell adhesion and the development of histotypic patterns.

1978 • 151 citations

Modulating Influence of Chemotactic Factor-Induced Cell Adhesiveness on Granulocyte Function

1979 • 151 citations

Motility and adhesive properties of high- and low-metastatic murine neoplastic cells.

1984 • 148 citations

Isolation and characterization of a collagen-binding glycoprotein from chondrocyte membranes.

1983 • 145 citations

Electron microscopic evidence for an asialoglycoprotein receptor on kupffer cells: Localization of lectin-mediated endocytosis

1982 • 144 citations

Biochemical investigations of retinotectal adhesive specificity

1977 • 138 citations

Production of fibronectin by human epithelial cells in culture.

1979 • 137 citations

Codistribution of heparan sulfate proteoglycan, laminin, and fibronectin in the extracellular matrix of normal rat kidney cells and their coordinate absence in transformed cells.

1982 • 135 citations

Specificity of Embryological Interactions

1978 • 134 citations

Adhesion characteristics of murine metastatic and nonmetastatic tumor cells in vitro.

1980 • 133 citations

Selective adhesion of embryonal carcinoma cells and differentiated cells by Ca2+-dependent sites

1981 • 131 citations

Mechanisms of metastasis

1979 • 128 citations

Role of nk cells in the antimetastatic effect of anticoagulant drugs

1984 • 126 citations

Lectin-like activities associated with human and murine neoplastic cells.

1981 • 125 citations

Molecular events in cells transformed by Rous Sarcoma virus.

1980 • 121 citations

Carbohydrate changes in glycoproteins of a poorly metastasizing wheat germ agglutinin-resistant melanoma clone.

1980 • 121 citations

Cell-substrate adhesivity

1972 • 120 citations

Mechanisms of Morphogenesis in Cell Cultures

1977 • 117 citations

Epibolin: a protein of human plasma that supports epithelial cell movement.

1981 • 116 citations

Altered organization of cell-substrate contacts and membrane-associated cytoskeleton in tumor cell variants exhibiting different metastatic capabilities.

1982 • 113 citations

Calcium-dependent cell-cell adhesion molecules common to hepatocytes and teratocarcinoma stem cells.

1983 • 110 citations

Proposed molecular basis of murine tumor cell-hepatocyte interaction.

1983 • 98 citations

Calcium movement and membrane potential changes in the early phase of neutrophil activation by phorbol myristate acetate: a study with ion-selective electrodes.

1982 • 97 citations

Metastatic potential of murine fibrosarcoma cells is influenced by cell surface laminin

1984 • 96 citations

Studies on the function of cell surface glycoproteins. I. Use of antisera to surface membranes in the identification of membrane components relevant to cell-substrate adhesion.

1979 • 96 citations

Determination of Adhesive Properties of Variant Metastatic Melanoma Cells to BALB/3T3 Cells and Their Virus-Transformed Derivatives by a Monolayer Attachment Assay 2

1976 • 95 citations

Adhesion-guided multicellular assembly: a commentary upon the postulates, real and imagined, of the differential adhesion hypothesis, with special attention to computer simulations of cell sorting

1975 • 94 citations

Two distinct adhesion mechanisms in embryonic neural retina cells

1981 • 93 citations

Multiple mechanisms of dissociated epidermal cell spreading.

1983 • 91 citations

Increase of asparagine-linked oligosaccharides with branched outer chains caused by cell transformation

1980 • 91 citations

Enzymic dissection of embryonic cell adhesive mechanisms: III. *Immunological identification of a component of the calcium-dependent adhesive system of embryonic chick neural retina cells

1982 • 90 citations

Comparison of two cell surface molecules involved in neural cell adhesion.

1984 • 90 citations

Isolation and Metastatic Properties of Detachment Variants of 816 Melanoma Cells 2

1978 • 90 citations

Immunofluorescent localization of a 39,000-dalton substrate of tyrosine protein kinases to the cytoplasmic surface of the plasma membrane.

1983 • 85 citations

Fibronectin enhancement of directed migration of B16 melanoma cells.

1984 • 84 citations

Studies on cell adhesion and recognition. II. The kinetics of cell adhesion and cell spreading on surfaces coated with carbohydrate-reactive proteins (glycosidases and lectins) and fibronectin.

1981 • 83 citations

Gangliosides as receptors for fibronectin?

1982 • 80 citations

Transformation Parameters and pp60^src Localization in Cells Infected with Partial Transformation Mutants of Rous Sarcoma Virus

1983 • 75 citations

Mammary-carcinoma cells in mouse liver: infiltration of liver tissue and interaction with Kupffer cells

1978 • 75 citations

Discrete primary locations of a tyrosine-protein kinase and of three proteins that contain phosphotyrosine in virally transformed chick fibroblasts.

1982 • 73 citations

The effect of various stimuli and calcium antagonists on the fluorescence response of chlorotetracycline-loaded human neutrophils

1982 • 71 citations

Surface membrane glycopeptides correlated with tumorigenesis

1973 • 70 citations

New surface component of fibroblast's focal contacts identified by a monoclonal antibody

1982 • 69 citations

Epithelial permeability and the transepithelial migration of human neutrophils.

1983 • 68 citations

Detection of a cell-surface antigen correlated with organ-specific metastasis

1980 • 67 citations

Organ specific metastasis with special reference to avian systems

1983 • 65 citations

Basal lamina and tissue recognition in malignant mammary tumors.

1980 • 65 citations

The p36 substrate of tyrosine-specific protein kinases co-localizes with non-erythrocyte alpha-spectrin antigen, p230, in surface lamina of cultured fibroblasts.

1983 • 64 citations

Low colony formation in vivo and in culture as exhibited by metastatic melanoma cells selected for reduced homotypic aggregation.

1983 • 63 citations

Calcium ions protect cell-substratum adhesion receptors against proteolysis

1984 • 62 citations

The relationship of fibroblast translocations to cell morphology and stress fibre density

1982 • 57 citations

Cell surface localization and tissue distribution of a hepatocyte cell-cell adhesion glycoprotein (cell-CAM 105)

1983 • 57 citations

Behavior of cells seeded in isolated fibronectin matrices.

1983 • 56 citations

Infiltration of tumour cells into cultures of isolated hepatocytes

1981 • 54 citations

Erythroid developmental agglutinin is a protein lectin mediating specific cell–cell adhesion between differentiating rabbit erythroblasts

1980 • 53 citations

The effects of chemotactic factors on the adhesiveness of rabbit neutrophil granulocytes

1979 • 52 citations

A lectin which binds specifically to β-D-galactoside groups is present at the earliest stages of chick embryo development

1979 • 51 citations

A comparison of membrane components of normal and transformed BALB/c cells

1977 • 51 citations

Invasion of Lymphosarcoma Cells Into the Perfused Mouse Liver

1977 • 50 citations

Fibonectin is a component of the surface coat of human neutrophils

1981 • 49 citations

Behavior of Intravenously Injected Malignant Lymphoma Cells. A Morphologic Study

1973 • 48 citations

Monoclonal antibodies which prevent experimental lung metastases

1984 • 45 citations

The membrane glycoproteins of the malignant cell

1980 • 45 citations

A mouse hepatocyte carbohydrate‐specific receptor and its interaction with liver‐metastasizing tumor cells

1983 • 45 citations

Enhanced metastatic potential of cloned low-metastatic Lewis lung carcinoma cells treated in vitro with dimethyl sulfoxide.

1984 • 44 citations

Calmodulin as a mediator of hormone action and cell regulation

1982 • 43 citations

Enrichment of A 140 KD surface glycoprotein in adherent, detergent-resistant cytoskeletons of cultured human fibroblasts

1980 • 43 citations

Enzymatic dissection of embryonic cell adhesive mechanisms

1981 • 40 citations

Selection for virulence and organ‐specific metastasis of herpesvirus‐transformed lymphoma cells

1980 • 40 citations

EFFECT OF DIMETHYL SULFOXIDE AND DIMETHYLFORMAMIDE ON THE GROWTH AND MORPHOLOGY OF TUMOR CELLS*

1975 • 40 citations

Trifluoperazine inhibits spreading and migration of cells in culture

1981 • 40 citations

Extracellular lectin and its glycosaminoglycan inhibitor in chick muscle cultures

1979 • 39 citations

Oncogenic intelligence: Oncogenes and inositol lipids

1984 • 39 citations

Invasion of Liver Tissue by Tumor Cells and Leukocytes: Comparative Ultrastructure

1978 • 38 citations

140 000 Dalton surface glycoprotein

1983 • 38 citations

Adhesive Characteristics of Tumor Cell Variants of High and Low Tumorigenic Potential<xref ref-type="fn" rid="FN2">2</xref>

1980 • 36 citations

Calmodulin in the membrane transport of Ca++

1981 • 34 citations

Transformation parameters and pp60src localization in cells infected with partial transformation mutants of Rous sarcoma virus.

1983 • 34 citations

Teratocarcinoma stem cell adhesion: the role of divalent cations and a cell surface lectin.

1983 • 33 citations

Effect of tubulin-binding agents on the infiltration of tumour cells into primary hepatocyte cultures

1982 • 32 citations

Cell-cell adhesion in the embryonic chick: Partial purification of liver adhesion molecules from liver membranes

1981 • 32 citations

Transient versus permanent expression of cancer-related glycopeptides on normal versus leukemic myeloid cells coinciding with marrow egress

1984 • 32 citations

Two different cell adhesion molecules—Cell-CAM 105 and a calcium-dependent protein—Occur on the surface of rat hepatocytes

1984 • 30 citations

Altered adhesiveness of tumor cell surface variants with reduced metastasizing capacity – reduced adhesiveness to vascular wall components in culture

1982 • 30 citations

Interactions between lymphoid tumor cells and isolated liver endothelial cells.

1984 • 30 citations

Kinetic and morphological analysis of the preferential adhesion of chick embryo neuronal cells to astroglial cells in culture

1982 • 29 citations

Cell shape and organization of cytoskeleton and surface fibronectin in non-tumorigenic and tumorigenic rat liver cultures

1982 • 29 citations

The metastatic spread of myeloma and leukemias in men

1975 • 29 citations

Fibronectin-independent adhesion of fibroblasts to the extracellular matrix: mediation by a high molecular weight membrane glycoprotein.

1981 • 29 citations

Immunocytochemical localization in normal and transformed human cells in tissue culture using a monoclonal antibody to the src protein of the Harvey strain of Murine Sarcoma Virus

1983 • 28 citations

Glycosaminoglycans and other carbohydrate groups bound to proteins of control and transformed cells.

1980 • 28 citations

Tumour cell-tumour cell emperipolesis studied by transmission electron microscopy

1973 • 27 citations

Effect of serum, fibronectin, and laminin on adhesion of rabbit intestinal epithelial cells in culture

1981 • 27 citations

Divalent cation-independent aggregation of rat-1 fibroblasts infected with a temperature-sensitive mutant of Rous sarcoma virus.

1981 • 27 citations

Calcium modulation of phorbol ester-induced alterations in murine macrophage morphology.

1983 • 26 citations

Metastasis—Clinical and Experimental Aspects

1981 • 26 citations

Phorbol myristate acetate-induced adherence of Walker 256 carcinosarcoma cells.

1982 • 26 citations

The adhesiveness of normal and SV40-transformed BALB/c 3T3 cells: Effects of culture density and shear rate

1982 • 24 citations

Infiltration of Lymphosarcoma Cells into Hepatocyte Cultures: Inhibition by Univalent Antibodies Against Liver Plasma Membranes and Lymphosarcoma Cells

1982 • 23 citations

Isolation of cloned variants of a rat hepatoma cell line with altered attachment to collagen, but normal attachment to fibronectin

1982 • 21 citations

Tumor cell-tumor cell emperipolesis

1967 • 21 citations

Adhesion of Tumor Cells to Hepatocytes: Different Mechanisms for Mammary Carcinoma Compared With Lymphosarcoma Cells

1984 • 20 citations

Organization Of Extracellular Matrix By Chick Embryonic Corneal Epithelial Cells In Culture And The Role Of Fibronectin In Adhesion

1984 • 19 citations

Laminin inhibits the adhesion of a murine tumor of macrophage origin

1982 • 19 citations

Infiltration of lymphosarcoma cells into hepatocyte cultures: inhibition by univalent antibodies against liver plasma membranes and lymphosarcoma cells

1982 • 18 citations

Malignant behaviour of three adenovirus‐2‐transformed brain cell lines and their methyl cellulose‐selected sub‐clones

1979 • 17 citations

Two chick embryonic adhesion systems: Molecular vs tissue specificity

1981 • 17 citations

Cell-to-substrate contacts in an adhesion-defective mutant of balb/c3T3 cells

1981 • 16 citations

Expression of Adhesion‐Related Membrane Components in Adherent Versus Nonadherent Hamster Melanoma Cells

1982 • 16 citations

Cell communication reduced by changes in cell surface carbohydrates

1982 • 13 citations

Is the movement of single cells within solid tissue masses induced by trypsinization?

1976 • 12 citations

Repair of a calcium-dependent adhesive mechanism of embryonic neural retina cells: kinetic and molecular analysis

1983 • 11 citations

Integral membrane antigens involved in cell-substratum adhesion of hepatocytes and hepatoma cells

1984 • 10 citations

Interactions of a mammalian β‐galactoside‐binding lectin with hamster fibroblasts

1983 • 10 citations

Adhesion of metastatic and non‐metastatic carcinoma cells to glass surfaces

1980 • 10 citations

Plasma membrane-associated filament systems in cultured cells visualized by dry-cleaving

1983 • 9 citations

Increase in homotypic aggregation of metastatic morris hepatoma cells after fusion with membranes from non‐metastatic cells

1983 • 7 citations

Possible common mechanisms of morphological and growth-related alterations accompanying neoplastic transformation.

1982 • 6 citations

Roles of calcium in aggregation of rat ascites hepatoma cells by cell surface-associated adhesive factor

1984 • 6 citations

Collagen cell attachment protein from rat hepatoma cells.

1981 • 6 citations

Characterization of the spreading process in human T lymphocytes

1983 • 6 citations

DNA repair: A laboratory manual of research procedures, 1, Part A.

1981 • 4 citations

Modification of the calcium-independent mechanism of cell adhesion in transformed BHK cells.

1983 • 2 citations