Mechanistic Distinctions between Excitotoxic and Acidotic Hippocampal Damage in an in vitro Model of Ischemia

Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral Microdialysis

1984 • 2,884 citations

Intracellular pH.

1981 • 2,440 citations

NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones

1986 • 1,842 citations

Memory and Brain

1987 • 1,821 citations

Brain Lesions, Obesity, and Other Disturbances in Mice Treated with Monosodium Glutamate

1969 • 1,802 citations

Blockade of N -Methyl-D-Aspartate Receptors May Protect Against Ischemic Damage in the Brain

1984 • 1,689 citations

Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assay

1987 • 1,280 citations

Rat hippocampal neurons in dispersed cell culture

1977 • 1,106 citations

Neurobiology of the hippocampus

1984 • 1,096 citations

Pharmacology of glutamate neurotoxicity in cortical cell culture: attenuation by NMDA antagonists

1988 • 983 citations

Glutamate becomes neurotoxic via the N-methyl-d-aspartate receptor when intracellular energy levels are reduced

1988 • 972 citations

Synaptic release of excitatory amino acid neurotransmitter mediates anoxic neuronal death

1984 • 893 citations

Glutamate neurotoxicity in cortical cell culture is calcium dependent

1985 • 818 citations

ATP and Brain Function

1989 • 812 citations

Moderate hyperglycemia augments ischemic brain damage

1982 • 730 citations

Effect of Ischemia on the In Vivo Release of Striatal Dopamine, Glutamate, and γ‐Aminobutyric Acid Studied by Intracerebral Microdialysis

1988 • 704 citations

Progress in Brain Research

1969 • 591 citations

Selective Neuronal Vulnerability: Morphological and Molecular Characteristics

1985 • 449 citations

What causes infarction in ischemic brain?

1983 • 382 citations

Acidosis reduces NMDA receptor activation, glutamate neurotoxicity, and oxygen-glucose deprivation neuronal injury in cortical cultures

1990 • 372 citations

Sensitivity of the developing rat brain to hypobaric/ischemic damage parallels sensitivity to N-methyl-aspartate neurotoxicity

1989 • 337 citations

Delayed neurotoxicity of excitatory amino acids In vitro

1987 • 332 citations

CARBOHYDRATE AND ENERGY METABOLISM IN PERINATAL RAT BRAIN: RELATION TO SURVIVAL IN ANOXIA

1975 • 311 citations

Brain extracellular ion composition and EEG activity following 10 minutes ischemia in normo- and hyperglycemic rats.

1981 • 308 citations

Sustained Dendritic Gradients of Ca ²⁺ Induced by Excitatory Amino Acids in CA1 Hippocampal Neurons

1988 • 301 citations

The effects of excitatory amino acids on intracellular calcium in single mouse striatal neurons in vitro

1987 • 268 citations

Hydrogen Ions Kill Brain at Concentrations Reached in Ischemia

1987 • 237 citations

Glucocorticoid toxicity in the hippocampus: in vitro demonstration

1988 • 219 citations

Neuroprotective effects of MK-801 in vivo: selectivity and evidence for delayed degeneration mediated by NMDA receptor activation

1988 • 216 citations

Mild acidosis protects hippocampal neurons from injury induced by oxygen and glucose deprivation

1990 • 202 citations

Neuronal death in vitro: parallelism between survivability of hippocampal neurones and sustained elevation of cytosolic Ca2+ after exposure to glutamate receptor agonist

1988 • 178 citations

Adhesion of chicken hepatocytes to polyacrylamide gels derivatized with N-acetylglucosamine

1978 • 171 citations

Transient focal ischemia in hyperglycemic rats is associated with increased cerebral infarction

1987 • 157 citations

Hypoxia-Induced Dysfunctions and Injury of Astrocytes in Primary Cell Cultures

1989 • 153 citations

Identification and properties of N-methyl-D-aspartate receptors in rat brain synaptic plasma membranes.

1986 • 146 citations

Intracellular pH in the Brain following Transient Ischemia

1983 • 136 citations

Focal ischemia of the rat brain, with special reference to the influence of plasma glucose concentration

1987 • 134 citations

Astrocytes protect cultured neurons from degeneration induced by anoxia

1987 • 122 citations

Hydrogen ion buffering during complete brain ischemia

1985 • 107 citations

Calcium Uptake Evoked by Electrical Stimulation is Enhanced Postischemically and Precedes Delayed Neuronal Death in CA1 of Rat Hippocampus: Involvement of N-Methyl-D-Aspartate Receptors

1988 • 106 citations

Increased glucose improves recovery of neuronal function after cerebral hypoxia in vitro

1987 • 104 citations

In vivo Identification and Quantitative Evaluation of Carrier-Mediated Transport of Lactate at the Cellular Level in the Striatum of Conscious, Freely Moving Rats

1988 • 102 citations

Long-Term Development of Selective Neuronal Loss and the Mechanism of Protection by 2-Amino-7-Phosphonoheptanoate in a Rat Model of Incomplete Forebrain Ischaemia

1988 • 102 citations

Control of synthesis of lactic acid dehydrogenases

1966 • 98 citations

Protection of hippocampal slices from young rats against anoxic transmission damage is due to better maintenance of ATP.

1989 • 97 citations

Dextrorphan and dextromethorphan attenuate hypoxic injury in neuronal culture

1987 • 91 citations

Brain Tissue Concentrations of ATP, Phosphocreatine, Lactate, and Tissue pH in Relation to Reduced Cerebral Blood Flow following Experimental Acute Middle Cerebral Artery Occlusion

1988 • 87 citations

Intracellular calcium mobilization triggered by a glutamate receptor in rat cultured hippocampal cells.

1989 • 77 citations

Histopathological and Hemodynamic Consequences of Complete versus Incomplete Ischemia in the Rat

1987 • 67 citations

Differential dependence on Ca2+ of and quisqualate neurotoxicity in young rat hippocampal slices

1989 • 63 citations

Roles for mitotic history in the generation and degeneration of hippocampal neuroarchitecture

1989 • 63 citations

Heterogeneous Distribution of Hydrogen and Bicarbonate Ions During Complete Brain Cischemia

1985 • 51 citations

Selective vulnerability of brain: New insights from the excitatory synapse

1986 • 50 citations

Brain Metabolism and Intracellular pH During Ischaemia: Effects of Systemic Glucose and Bicarbonate Administration Studied by ³¹P and ¹H Nuclear Magnetic Resonance Spectroscopy In Vivo in the Lamb

1988 • 45 citations

The major anoxic stress response protein p34 is a distinct lactate dehydrogenase

1988 • 34 citations

Oxygen Deficiency and Brain Damage: Localization, Evolution in Time, and Mechanisms of Damage

1985 • 30 citations

Cerebrovascular Diseases

1985 • 18 citations

Correlation between intracellular pH and lactate levels in the rat brain during potassium cyanide induced metabolism blockade: A combined 31P-1H in vivo nuclear magnetic spectroscopy study

1989 • 17 citations