A critical interpretation of experiments of binding of peptide hormone to specific receptors by computer modelling

Theoretical aspects of DNA-protein interactions: Co-operative and non-co-operative binding of large ligands to a one-dimensional homogeneous lattice

1974 • 2,905 citations

Development of hormone receptors and hormonal responsiveness in vitro. Insulin receptors and insulin sensitivity in the preadipocyte and adipocyte forms of 3T3-L1 cells.

1978 • 678 citations

Properties of graphical representations of multiple classes of binding sites

1971 • 616 citations

Mathematical theory of complex ligand-binding systems at equilibrium: Some methods for parameter fitting

1972 • 615 citations

Quantitative Aspects of the Insulin-Receptor Interaction in Liver Plasma Membranes

1974 • 378 citations

Binding and degradation of 125I-labelled insulin by isolated rat fat cells

1973 • 339 citations

Theory of the measurement of weak molecular complexes. I. General considerations

1969 • 337 citations

Determination of Binding Parameters from Scatchard Plots

1974 • 149 citations

Regulation of Insulin Receptors and Insulin Responsiveness in 3T3-L1 Fatty Fibroblasts

1979 • 147 citations

Binding of 125I-labeled glucagon and glucagon-stimulated accumulation of adenosine 3‘:5‘-monophosphate in isolated intact rat hepatocytes. Evidence for receptor heterogeneity.

1978 • 127 citations

Protein affinities for small molecules: Conceptions and misconceptions

1979 • 108 citations

Effects of GTP on binding of (3H) glucagon to receptors in rat hepatic plasma membranes.

1977 • 91 citations

Short-term Regulation of Insulin Receptor Affinity in Man

1980 • 73 citations

Erythrocyte Insulin Receptors in Non-insulin-dependent Diabetes Mellitus

1980 • 60 citations

Characterization of the Insulin Receptor and Insulin-Degrading Activity from Human Lymphocytes by Quantitative Polyacrylamide Gel Electrophoresis*

1980 • 41 citations

Numerical analysis of binding studies: A direct procedure avoiding the pitfalls of a scatchard analysis of equilibrium data for unknown binding models

1979 • 32 citations

A quantitative analysis of glucagon binding to isolated intact neonatal and adult rat hepatocytes on the basis of two different binding models

1982 • 22 citations

Direct Evidence for Downregulation of Insulin Receptors by Physiologic Hyperinsulinemia in Man

1980 • 21 citations

The application of robust non-linear regression methods for fitting hyperbolic scatchard plots

1979 • 18 citations