Role of the LDL Receptor in the Regulation of Cholesterol and Lipoprotein Metabolism

Binding and Degradation of Low Density Lipoproteins by Cultured Human Fibroblasts

1974 • 1,481 citations

Familial hypercholesterolemia: Defective binding of lipoproteins to cultured fibroblasts associated with impaired regulation of 3-hydroxy-3-methylglutaryl coenzyme a reductase activity

1974 • 589 citations

Regulation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase Activity in Cultured Human Fibroblasts

1974 • 545 citations

Regulation of the activity of the low density lipoprotein receptor in human fibroblasts

1975 • 477 citations

Familial Hypercholesterolemia: Identification of a Defect in the Regulation of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Activity Associated with Overproduction of Cholesterol

1973 • 442 citations

Role of lysosomal acid lipase in the metabolism of plasma low density lipoprotein. Observations in cultured fibroblasts from a patient with cholesteryl ester storage disease.

1975 • 382 citations

Cholesterol ester formation in cultured human fibroblasts. Stimulation by oxygenated sterols.

1975 • 364 citations

Regulation of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Activity in Human Fibroblasts by Lipoproteins

1973 • 348 citations

Role of the low density lipoprotein receptor in regulating the content of free and esterified cholesterol in human fibroblasts.

1975 • 317 citations

Inhibition of proteolytic degradation of low density lipoprotein in human fibroblasts by chloroquine, concanavalin A, and Triton WR 1339.

1975 • 306 citations

Effect of cholesterol feeding and fasting on sterol synthesis in seventeen tissues of the rat

1967 • 296 citations

Esterification of Low Density Lipoprotein Cholesterol in Human Fibroblasts and Its Absence in Homozygous Familial Hypercholesterolemia

1974 • 287 citations

Expression of the Familial Hypercholesterolemia Gene in Heterozygotes: Mechanism for a Dominant Disorder in Man

1974 • 253 citations

Reduction in cholesterol and low density lipoprotein synthesis after portacaval shunt surgery in a patient with homozygous familial hypercholesterolemia.

1975 • 245 citations

Cholesterol synthesis in the squirrel monkey: relative rates of synthesis in various tissues and mechanisms of control

1968 • 220 citations

Receptor-dependent hydrolysis of cholesteryl esters contained in plasma low density lipoprotein.

1975 • 210 citations

Abnormal induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase in leukocytes from subjects with heterozygous familial hypercholesterolemia.

1975 • 148 citations

The metabolism of the apoprotein of plasma low density lipoprotein in familial hype rbetalipoproteinaemia in the homozygous form

1975 • 142 citations

The Lipids and Lipoproteins of Human Peripheral Lymph, with Observations on the Transport of Cholesterol from Plasma and Tissues into Lymph

1973 • 127 citations

Atherogenesis: Initiating Factors

1973 • 126 citations

Lipid Metabolism in Tissue Culture Cells1 1This investigation was supported in part by Public Health Service Research Grant 5-RO1-HE 09103 from the National Heart Institute and Public Health Service Research Fellowship 5-F3-AM-34, 974 from the National Institute of Arthritis and Metabolic Diseases.

1969 • 123 citations

Familial hypercholesterolemia

1975 • 113 citations

Advances in Experimental Medicine and Biology

1973 • 99 citations

Control of lipid metabolism in cultured cells

1972 • 70 citations

Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in cultured swine aortic smooth muscle cells by plasma lipoproteins

1975 • 58 citations

Use of mutant fibroblasts in the analysis of the regulation of cholesterol metabolism in human cells

1975 • 46 citations

Control of Lipid Metabolism in Human Leukocytes

1973 • 37 citations

The Metabolism of Low-Density Lipoprotein in a Patient with Familial Hyperbetalipoproteinaemia

1974 • 32 citations