The semaphorins: versatile regulators of tumour progression and tumour angiogenesis

Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

1995 • 3,977 citations

Neuropilin-1 Is Expressed by Endothelial and Tumor Cells as an Isoform-Specific Receptor for Vascular Endothelial Growth Factor

1998 • 2,440 citations

EGF–ERBB signalling: towards the systems level

2006 • 1,911 citations

Endothelial/Pericyte Interactions

2005 • 1,909 citations

Talin Binding to Integrin ß Tails: A Final Common Step in Integrin Activation

2003 • 1,168 citations

Neuropilin Is a Semaphorin III Receptor

1997 • 1,166 citations

Collapsin: A protein in brain that induces the collapse and paralysis of neuronal growth cones

1993 • 1,146 citations

Neuropilin Is a Receptor for the Axonal Chemorepellent Semaphorin III

1997 • 1,131 citations

Plexins Are a Large Family of Receptors for Transmembrane, Secreted, and GPI-Anchored Semaphorins in Vertebrates

1999 • 1,118 citations

Plexin-Neuropilin-1 Complexes Form Functional Semaphorin-3A Receptors

1999 • 803 citations

CRMP-2 binds to tubulin heterodimers to promote microtubule assembly

2002 • 739 citations

Neuropilin-1 Conveys Semaphorin and VEGF Signaling during Neural and Cardiovascular Development

2003 • 707 citations

Neuropilin-2, a Novel Member of the Neuropilin Family, Is a High Affinity Receptor for the Semaphorins Sema E and Sema IV but Not Sema III

1997 • 650 citations

Abnormal lymphatic vessel development in neuropilin 2 mutant mice

2002 • 619 citations

A model for gene therapy of human hereditary lymphedema

2001 • 585 citations

Class 3 semaphorins control vascular morphogenesis by inhibiting integrin function

2003 • 559 citations

Blocking Neuropilin-1 Function Has an Additive Effect with Anti-VEGF to Inhibit Tumor Growth

2007 • 526 citations

Semaphorin 3E and Plexin-D1 Control Vascular Pattern Independently of Neuropilins

2004 • 518 citations

Neuropilin-1 Mediates Collapsin-1/Semaphorin III Inhibition of Endothelial Cell Motility

1999 • 469 citations

VEGF₁₆₅ mediates formation of complexes containing VEGFR‐2 and neuropilin‐1 that enhance VEGF₁₆₅‐receptor binding

2002 • 456 citations

The Semaphorin 4D receptor controls invasive growth by coupling with Met

2002 • 428 citations

Analysis of the L1-Deficient Mouse Phenotype Reveals Cross-Talk between Sema3A and L1 Signaling Pathways in Axonal Guidance

2000 • 423 citations

Neuropilin-2 and Neuropilin-1 Are Receptors for the 165-Amino Acid Form of Vascular Endothelial Growth Factor (VEGF) and of Placenta Growth Factor-2, but Only Neuropilin-2 Functions as a Receptor for the 145-Amino Acid Form of VEGF

2000 • 411 citations

Semaphorin3A signalling is mediated via sequential Cdk5 and GSK3β phosphorylation of CRMP2: implication of common phosphorylating mechanism underlying axon guidance and Alzheimer's disease

2005 • 390 citations

Semaphorin 5A Is a Bifunctional Axon Guidance Cue Regulated by Heparan and Chondroitin Sulfate Proteoglycans

2004 • 379 citations

Targeting of both mouse neuropilin-1 and neuropilin-2 genes severely impairs developmental yolk sac and embryonic angiogenesis

2002 • 371 citations

The Semaphorin 4D Receptor Plexin-B1 Is a GTPase Activating Protein for R-Ras

2004 • 371 citations

The semaphorins.

2006 • 364 citations

PlexinD1 and Semaphorin Signaling Are Required in Endothelial Cells for Cardiovascular Development

2004 • 358 citations

Plexin-B1 Directly Interacts with PDZ-RhoGEF/LARG to Regulate RhoA and Growth Cone Morphology

2002 • 357 citations

Neuropilin-2 Is a Receptor for Semaphorin IV Insight into the Structural Basis of Receptor Function and Specificity

1998 • 352 citations

MICALs, a Family of Conserved Flavoprotein Oxidoreductases, Function in Plexin-Mediated Axonal Repulsion

2002 • 351 citations

Neuropilin-1 Is a Placenta Growth Factor-2 Receptor

1998 • 344 citations

Identification of CD72 as a Lymphocyte Receptor for the Class IV Semaphorin CD100

2000 • 343 citations

Phosphorylation of cofilin by LIM-kinase is necessary for semaphorin 3A-induced growth cone collapse

2001 • 342 citations

Blocking Neuropilin-2 Function Inhibits Tumor Cell Metastasis

2008 • 333 citations

Fyn and Cdk5 Mediate Semaphorin-3A Signaling, Which Is Involved in Regulation of Dendrite Orientation in Cerebral Cortex

2002 • 331 citations

Lim kinases, regulators of actin dynamics

2006 • 320 citations

Neuropilin‐1 expression by tumor cells promotes tumor angiogenesis and progression

2000 • 310 citations

Class IV semaphorin Sema4A enhances T-cell activation and interacts with Tim-2

2002 • 306 citations

Differential Binding of Vascular Endothelial Growth Factor B Splice and Proteolytic Isoforms to Neuropilin-1

1999 • 304 citations

Functional interaction of VEGF‐C and VEGF‐D with neuropilin receptors

2006 • 284 citations

Cloning and Characterization of Neuropilin-1-Interacting Protein: A PSD-95/Dlg/ZO-1 Domain-Containing Protein That Interacts with the Cytoplasmic Domain of Neuropilin-1

1999 • 282 citations

Neuropilin-2 interacts with VEGFR-2 and VEGFR-3 and promotes human endothelial cell survival and migration

2006 • 275 citations

Dual roles of Sema6D in cardiac morphogenesis through region-specific association of its receptor, Plexin-A1, with off-track and vascular endothelial growth factor receptor type 2

2004 • 274 citations

Semaphorin 3F, a chemorepulsant for endothelial cells, induces a poorly vascularized, encapsulated, nonmetastatic tumor phenotype

2004 • 269 citations

Differential expression of neuropilin-1 and neuropilin-2 in arteries and veins

2001 • 262 citations

The organization of F-actin and microtubules in growth cones exposed to a brain-derived collapsing factor.

1993 • 262 citations

Phosphorylation by Rho Kinase Regulates CRMP-2 Activity in Growth Cones

2005 • 254 citations

Interactions between growth factor receptors and adhesion molecules: breaking the rules

2003 • 250 citations

Gating of Sema3E/PlexinD1 Signaling by Neuropilin-1 Switches Axonal Repulsion to Attraction during Brain Development

2007 • 248 citations

Sema4D induces angiogenesis through Met recruitment by Plexin B1

2005 • 248 citations

Regulation of Angiogenesis by Eph–Ephrin Interactions

2007 • 247 citations

The role of neuropilins in cancer

2006 • 247 citations

The chemorepulsive activity of secreted semaphorins is regulated by furin-dependent proteolytic processing

1997 • 238 citations

Class IV Semaphorins Promote Angiogenesis by Stimulating Rho-Initiated Pathways through Plexin-B

2004 • 236 citations

Plasticity of endothelial cells during arterial-venous differentiation in the avian embryo

2001 • 235 citations

Semaphorin-3A guides radial migration of cortical neurons during development

2007 • 234 citations

Neuropilin-1 is a receptor for transforming growth factor β-1, activates its latent form, and promotes regulatory T cell activity

2008 • 232 citations

Semaphorin 3A–Vascular Endothelial Growth Factor-165 Balance Mediates Migration and Apoptosis of Neural Progenitor Cells by the Recruitment of Shared Receptor

2001 • 227 citations

Semaphorin-3F Is an Inhibitor of Tumor Angiogenesis

2004 • 225 citations

The A5 antigen, a candidate for the neuronal recognition molecule, has homologies to complement components and coagulation factors

1991 • 224 citations

Structural basis for ligand and heparin binding to neuropilin B domains

2007 • 223 citations

Proprotein convertases: “Master switches” in the regulation of tumor growth and progression

2005 • 220 citations

A role for axon guidance receptors and ligands in blood vessel development and tumor angiogenesis

2005 • 219 citations

Characterization of Neuropilin-1 Structural Features That Confer Binding to Semaphorin 3A and Vascular Endothelial Growth Factor 165

2002 • 219 citations

Differential Requirement for Plexin-A3 and -A4 in Mediating Responses of Sensory and Sympathetic Neurons to Distinct Class 3 Semaphorins

2005 • 219 citations

Semaphorin-3A and Semaphorin-3F Work Together to Repel Endothelial Cells and to Inhibit Their Survival by Induction of Apoptosis

2007 • 217 citations

FARP2 triggers signals for Sema3A-mediated axonal repulsion

2005 • 216 citations

Dual Functional Activity of Semaphorin 3B Is Required for Positioning the Anterior Commissure

2005 • 216 citations

Plexin B Regulates Rho through the Guanine Nucleotide Exchange Factors Leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF

2002 • 213 citations

Cis and trans interactions of L1 with neuropilin-1 control axonal responses to semaphorin 3A

2002 • 212 citations

Inhibition of lung cancer cell growth and induction of apoptosis after reexpression of 3p21.3 candidate tumor suppressor gene SEMA3B

2001 • 212 citations

CD38 and CD100 lead a network of surface receptors relaying positive signals for B-CLL growth and survival

2004 • 212 citations

Galectin-1, a novel ligand of neuropilin-1, activates VEGFR-2 signaling and modulates the migration of vascular endothelial cells

2008 • 211 citations

Semaphorin 3A suppresses VEGF-mediated angiogenesis yet acts as a vascular permeability factor

2008 • 208 citations

Semaphorin 4D provides a link between axon guidance processes and tumor-induced angiogenesis

2006 • 205 citations

Domains in plexins: links to integrins and transcription factors

1999 • 204 citations

PlexinA1 Autoinhibition by the Plexin Sema Domain

2001 • 203 citations

Selective Binding of VEGF121 to One of the Three Vascular Endothelial Growth Factor Receptors of Vascular Endothelial Cells

1996 • 200 citations

Competing autocrine pathways involving alternative neuropilin-1 ligands regulate chemotaxis of carcinoma cells.

2003 • 198 citations

Neuropilin-1 Binds to VEGF121 and Regulates Endothelial Cell Migration and Sprouting

2007 • 197 citations

Distinct 3p21.3 deletions in lung cancer and identification of a new human semaphorin.

1996 • 193 citations

Regulated surface expression and shedding support a dual role for semaphorin 4D in platelet responses to vascular injury

2007 • 189 citations

Plexin-B semaphorin receptors interact directly with active Rac and regulate the actin cytoskeleton by activating Rho

2001 • 187 citations

Neuropilin-1 promotes human glioma progression through potentiating the activity of the HGF/SF autocrine pathway

2007 • 183 citations

Semaphorin 3B (SEMA3B) induces apoptosis in lung and breast cancer, whereas VEGF ₁₆₅ antagonizes this effect

2004 • 179 citations

The semaphorin 3A receptor may directly regulate the activity of small GTPases

2000 • 177 citations

Interplay between scatter factor receptors and B plexins controls invasive growth

2004 • 176 citations

Synectin, syndecan-4 cytoplasmic domain binding PDZ protein, inhibits cell migration

2000 • 172 citations

MT1-MMP Controls Tumor-induced Angiogenesis through the Release of Semaphorin 4D

2007 • 167 citations

The semaphorin receptor plexin-B1 signals through a direct interaction with the Rho-specific nucleotide exchange factor, LARG

2002 • 164 citations

Interactions of Multiple Heparin Binding Growth Factors with Neuropilin-1 and Potentiation of the Activity of Fibroblast Growth Factor-2

2005 • 164 citations

Semaphorin-4A, an activator for T-cell-mediated immunity, suppresses angiogenesis via Plexin-D1

2007 • 163 citations

Glycosaminoglycan modification of neuropilin-1 modulates VEGFR2 signaling

2006 • 161 citations

Plexin-B1/RhoGEF–mediated RhoA activation involves the receptor tyrosine kinase ErbB-2

2004 • 160 citations

Neuropilin-1 in Human Colon Cancer

2004 • 158 citations

Neuropilin-1 and neuropilin-2 act as coreceptors, potentiating proangiogenic activity

2007 • 158 citations

Antagonistic Effects of Rnd1 and RhoD GTPases Regulate Receptor Activity in Semaphorin 3A-Induced Cytoskeletal Collapse

2002 • 158 citations

Semaphorin-3A is expressed by tumor cells and alters T-cell signal transduction and function

2005 • 155 citations

CD100/Plexin-B1 interactions sustain proliferation and survival of normal and leukemic CD5+ B lymphocytes

2003 • 155 citations

Therapeutic Targeting of Neuropilin-2 on Colorectal Carcinoma Cells Implanted in the Murine Liver

2008 • 153 citations

The sema domain

2004 • 152 citations

Semaphorins as Mediators of Neuronal Apoptosis

1999 • 152 citations

Plexin‐B3 is a functional receptor for semaphorin 5A

2004 • 151 citations

Vascular Endothelial Growth Factor Receptor-1 and Neuropilin-2 Form Complexes

2001 • 148 citations

Isolation of the Human Semaphorin III/F Gene (SEMA3F) at Chromosome 3p21, a Region Deleted in Lung Cancer

1996 • 148 citations

A 70 Amino Acid Region within the Semaphorin Domain Activates Specific Cellular Response of Semaphorin Family Members

1997 • 145 citations

ErbB-2 and Met Reciprocally Regulate Cellular Signaling via Plexin-B1

2007 • 137 citations

Semaphorin 3F gene from human 3p21.3 suppresses tumor formation in nude mice.

2002 • 134 citations

Binding of Rac1, Rnd1, and RhoD to a Novel Rho GTPase Interaction Motif Destabilizes Dimerization of the Plexin-B1 Effector Domain

2007 • 134 citations

Hepatocyte Growth Factor–Mediated Cell Invasion in Pancreatic Cancer Cells Is Dependent on Neuropilin-1

2007 • 131 citations

Sema4D/plexin‐B1 activates GSK‐3β through R‐Ras GAP activity, inducing growth cone collapse

2006 • 130 citations

Selective requirements for NRP1 ligands during neurovascular patterning

2007 • 123 citations

R-Ras is a global regulator of vascular regeneration that suppresses intimal hyperplasia and tumor angiogenesis

2005 • 120 citations

Semaphorin 3C regulates endothelial cell function by increasing integrin activity

2006 • 119 citations

Plexin-B1 Utilizes RhoA and Rho Kinase to Promote the Integrin-dependent Activation of Akt and ERK and Endothelial Cell Motility

2007 • 118 citations

Identification of ATF-3, caveolin-1, DLC-1, and NM23-H2 as putative antitumorigenic, progesterone-regulated genes for ovarian cancer cells by gene profiling

2005 • 118 citations

Allelic loss on chromosome 3p21.3 and promoter hypermethylation of semaphorin 3B in non-small cell lung cancer.

2003 • 117 citations

The Plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding

2002 • 116 citations

Involvement of Fes/Fps tyrosine kinase in semaphorin3A signaling

2002 • 115 citations

The Chemorepulsive Activity of the Axonal Guidance Signal Semaphorin D Requires Dimerization

1998 • 113 citations

Proteolytic Processing Converts the Repelling Signal Sema3E into an Inducer of Invasive Growth and Lung Metastasis

2005 • 113 citations

Increased class 3 semaphorin expression modulates the invasive and adhesive properties of prostate cancer cells

2007 • 111 citations

Release of MICAL Autoinhibition by Semaphorin-Plexin Signaling Promotes Interaction with Collapsin Response Mediator Protein

2008 • 111 citations

Semaphorin SEMA3F and VEGF Have Opposing Effects on Cell Attachment and Spreading

2003 • 110 citations

Targeted delivery to PEPT1-overexpressing cells: Acidic, basic, and secondary floxuridine amino acid ester prodrugs

2005 • 107 citations

Semaphorin SEMA3F Has a Repulsing Activity on Breast Cancer Cells and Inhibits E-Cadherin-Mediated Cell Adhesion

2005 • 106 citations

Neuropilin-1 interacts with integrin β1 and modulates pancreatic cancer cell growth, survival and invasion

2007 • 103 citations

Close Homolog of L1 and Neuropilin 1 Mediate Guidance of Thalamocortical Axons at the Ventral Telencephalon

2007 • 101 citations

Human malignant glioma cells express semaphorins and their receptors, neuropilins and plexins

2003 • 100 citations

Collapsin-1 Covalently Dimerizes, and Dimerization Is Necessary for Collapsing Activity

1998 • 98 citations

p190 Rho-GTPase activating protein associates with plexins and it is required for semaphorin signalling

2005 • 96 citations

Role of neural guidance signals in blood vessel navigation

2004 • 96 citations

Neogenin: One receptor, many functions

2006 • 94 citations

Association of axon guidance factor Semaphorin 3A with poor outcome in pancreatic cancer

2007 • 94 citations

Allele loss and epigenetic inactivation of 3p21.3 in malignant liver tumors

2005 • 94 citations

Possible Role of Semaphorin 3F, a Candidate Tumor Suppressor Gene at 3p21.3, in p53-Regulated Tumor Angiogenesis Suppression

2007 • 92 citations

Plexin-B1 mutations in prostate cancer

2007 • 89 citations

Breast cancer cells secreted platelet‐derived growth factor‐induced motility of vascular smooth muscle cells is mediated through neuropilin‐1

2006 • 89 citations

Plexin-B1 plays a redundant role during mouse development and in tumour angiogenesis

2007 • 81 citations

Transmembrane Domain Interactions Control Biological Functions of Neuropilin-1

2007 • 81 citations

Cross‐talk between vascular endothelial growth factor and semaphorin‐3A pathway in the regulation of normal and malignant mesothelial cell proliferation

2003 • 80 citations

Identification of semaphorin E gene expression in metastatic human lung adenocarcinoma cells by mRNA differential display

1999 • 78 citations

Semaphorin SEMA3F Affects Multiple Signaling Pathways in Lung Cancer Cells

2007 • 78 citations

Neuropilin-1 Suppresses Tumorigenic Properties in a Human Pancreatic Adenocarcinoma Cell Line Lacking Neuropilin-1 Coreceptors

2005 • 77 citations

Functional Regulation of Semaphorin Receptors by Proprotein Convertases

2003 • 76 citations

Selective Suppression of In Vivo Tumorigenicity by Semaphorin SEMA3F in Lung Cancer Cells

2005 • 74 citations

RanBPM Contributes to Semaphorin3A Signaling through Plexin-A Receptors

2006 • 74 citations

Recombinant semaphorin 6A-1 ectodomain inhibits in vivo growth factor and tumor cell line-induced angiogenesis

2005 • 70 citations

MICAL flavoprotein monooxygenases: Expression during neural development and following spinal cord injuries in the rat

2005 • 69 citations

Neuropilin-1 Modulates p53/Caspases Axis to Promote Endothelial Cell Survival

2007 • 68 citations

Plexin D1 Expression Is Induced on Tumor Vasculature and Tumor Cells: A Novel Target for Diagnosis and Therapy?

2005 • 68 citations

Expression of semaphorins, vascular endothelial growth factor, and their common receptor neuropilins and alleic loss of semaphorin locus in epithelial ovarian neoplasms: increased ratio of vascular endothelial growth factor to semaphorin is a poor prognostic factor in ovarian carcinomas

2006 • 67 citations

Neuropilin‐1 and neuropilin‐2 enhance VEGF₁₂₁stimulated signal transduction by the VEGFR‐2 receptor

2006 • 66 citations

Poor Outcome in Estrogen Receptor–Positive Breast Cancers Predicted by Loss of Plexin B1

2007 • 66 citations

Potential role of the Slit/Robo signal pathway in angiogenesis

2006 • 61 citations

Genome-wide gene expression profiles of clear cell renal cell carcinoma: Identification of molecular targets for treatment of renal cell carcinoma

2006 • 61 citations

CHL1 promotes Sema3A‐induced growth cone collapse and neurite elaboration through a motif required for recruitment of ERM proteins to the plasma membrane

2007 • 57 citations

Collapsin Response Mediator Protein Switches RhoA and Rac1 Morphology in N1E-115 Neuroblastoma Cells and Is Regulated by Rho Kinase

2001 • 53 citations

CLCP1 interacts with semaphorin 4B and regulates motility of lung cancer cells

2007 • 52 citations

Role of netrin-1 and netrin-1 dependence receptors in colorectal cancers

2005 • 48 citations

Inhibition of vascular endothelial growth factor (VEGF)-165 and semaphorin 3A–mediated cellular invasion and tumor growth by the VEGF signaling inhibitor ZD4190 in human colon cancer cells and xenografts

2006 • 44 citations

High-resolution analysis of 3p deletion in neuroblastoma and differential methylation of the SEMA3B tumor suppressor gene

2007 • 40 citations

Null and conditionalsemaphorin 3B alleles using a flexiblepuro?tk loxP/FRT vector

2005 • 39 citations

The preserved expression of neuropilin (NRP) 1 contributes to a better prognosis in colon cancer

2006 • 38 citations

Profiling estrogen-regulated gene expression changes in normal and malignant human ovarian surface epithelial cells

2005 • 36 citations

Immune Semaphorins: Increasing Members and Their Diverse Roles

2007 • 35 citations

Characterization of Insulin Inhibition of Transactivation by a C-terminal Fragment of the Forkhead Transcription Factor Foxo1 in Rat Hepatoma Cells

2003 • 27 citations

The Fer tyrosine kinase regulates an axon retraction response to Semaphorin 3A in dorsal root ganglion neurons

2007 • 25 citations

Semaphorin Signaling in the Immune System

2007 • 25 citations

The race associated allele of Semaphorin 3B ( SEMA3B ) T415I and its role in lung cancer in African-Americans and Latino-Americans

2005 • 18 citations