Chinese hamster cells deficient in ornithine decarboxylase activity: Reversion by gene amplification and by azacytidine treatment

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Purification of Biologically Active Globin Messenger RNA by Chromatography on Oligothymidylic acid-Cellulose

1972 • 6,922 citations

MUTATIONS OF BACTERIA FROM VIRUS SENSITIVITY TO VIRUS RESISTANCE

1943 • 3,852 citations

RNA molecular weight determinations by gel electrophoresis under denaturing conditions, a critical reexamination

1977 • 3,548 citations

Cellular differentiation, cytidine analogs and DNA methylation

1980 • 1,803 citations

Polyamine metabolism and function

1982 • 1,649 citations

1,4-Diaminobutane (Putrescine), Spermidine, and Spermine

1976 • 1,203 citations

Catalytic irreversible inhibition of mammalian ornithine decarboxylase (E.C.4.1.1.17) by substrate and product analogs

1978 • 998 citations

Isolation and partial characterization of the Drosophila alcohol dehydrogenase gene.

1980 • 570 citations

On the nature of hereditable variation in cultured somatic cells

1976 • 497 citations

Advances in polyamine research in 2007

2007 • 324 citations

Polyamines in Biomedical Research

1981 • 311 citations

Isolation of transforming DNA: Cloning the hamster aprt gene

1980 • 226 citations

Alpha-methyl ornithine, a potent competitive inhibitor of ornithine decarboxylase, blocks proliferation of rat hepatoma cells in culture.

1976 • 213 citations

Induction of thymidine kinase in enzyme-deficient chinese hamster cells

1982 • 205 citations

Androgen induction of ornithine decarboxylase mRNA in mouse kidney as studied by complementary DNA.

1984 • 176 citations

Specificity of different classes of ethylating agents toward various sites of HeLa cell DNA in vitro and in vivo

1975 • 159 citations

Mutants of Escherichia coli that do not contain 1,4-diaminobutane (putrescine) or spermidine.

1979 • 158 citations

Changes in mouse kidney ornithine decarboxylase activity are brought about by changes in the amount of enzyme protein as measured by radioimmunoassay.

1983 • 144 citations

Polyamine starvation causes disappearance of actin filaments and microtubules in polyamine-auxotrophic CHO cells

1981 • 142 citations

Cloned cDNA sequences of the hypoxanthine/guanine phosphoribosyltransferase gene from a mouse neuroblastoma cell line found to have amplified genomic sequences.

1982 • 136 citations

An ornithine decarboxylase-deficient mutant of Chinese hamster ovary cells.

1982 • 136 citations

CURRENT TOPICS IN CELLULAR REGULATION

1996 • 107 citations

Effects of Polyamines on the Structure and Reactivity of tRNA

1976 • 107 citations

Construction of an Escherichia coli strain unable to synthesize putrescine, spermidine, or cadaverine: characterization of two genes controlling lysine decarboxylase

1980 • 101 citations

Role of polyamines in macromolecular synthesis

1981 • 93 citations

Isolation and characterization of Saccharomyces cerevisiae mutants deficient in S-adenosylmethionine decarboxylase, spermidine, and spermine

1978 • 93 citations

Polyamine auxotrophs of Saccharomyces cerevisiae

1978 • 87 citations

Analogs of ornithine as inhibitors of ornithine decarboxylase. New deductions concerning the topography of the enzyme's active site

1978 • 83 citations

Polyamines in Mammalian Tumors Part I

1981 • 80 citations

Binding of radioactive α-difluoromethylorithine to rat liver ornithine decarboxylase

1981 • 79 citations

The Relation between Reaction Kinetics and Mutagenic Action of Monofunctional Alkylating Agents in Higher Eukaryotic Systems: Interspecies Comparisons

1982 • 72 citations

Inhibitors of polyamine biosynthesis. 1. .alpha.-Methyl-(+-)-ornithine, an inhibitor of ornithine decarboxylase

1974 • 71 citations

Induction of prolactin-deficient variants of GH3 rat pituitary tumor cells by ethyl methanesulfonate: reversion by 5-azacytidine, a DNA methylation inhibitor.

1982 • 63 citations

Regulatory mutations affecting ornithine decarboxylase activity in Saccharomyces cerevisiae

1980 • 61 citations

Polyamine-deficient Neurospora crassa mutants and synthesis of cadaverine

1982 • 59 citations

Polyamine dependence of Chinese hamster ovary cells in serum-free culture is due to deficient arginase activity

1982 • 55 citations

Antibodies to Ornithine Decarboxylase. Immunochemical Cross-reactivity.

1982 • 52 citations

Streptomycin Resistance ( rpsL ) Produces an Absolute Requirement for Polyamines for Growth of an Escherichia coli Strain Unable to Synthesize Putrescine and Spermidine [Δ( speA-speB ) Δ specC ]

1981 • 49 citations

Polyamine deprivation causes major chromosome aberrations in a polyamine-dependent Chinese hamster ovary cell line

1982 • 42 citations

Purification by affinity chromatography and preliminary characterization of ornithine decarboxylase from simian virus 40-transformed 3T3 mouse fibroblasts

1977 • 42 citations

Regulation of polyamine synthesis in relation to putrescine and spermidine pools in Neurospora crassa.

1981 • 41 citations

Chinese hamster ovary cells resistant to alpha-difluoromethylornithine are overproducers of ornithine decarboxylase.

1983 • 40 citations

Induction of ornithine decarboxylase activity in a temperature-sensitive cell cycle mutant of Chinese hamster cells.

1978 • 27 citations

Effects of Detergent on Ornithine Decarboxylase from Rat Liver

1981 • 25 citations

Amplification versus mutation as a mechanism for reversion of anHGPRT mutation

1984 • 25 citations

A mutant of Chinese hamster ovary cells resistant toα-methyl- andα-difluoromethylornithine

1982 • 20 citations

Initiation, elongation and termination of polypeptide synthesis in cell-free systems from polyamine-deficient bacteria

1981 • 12 citations

ON THE ORIGIN OF MUTANTS OF SOMATIC CELLS

1979 • 8 citations