Pyrimidine Metabolism in Man

CONTROL BY URACIL OF FORMATION OF ENZYMES REQUIRED FOR OROTATE SYNTHESIS

1957 • 162 citations

Dependence of Bone Marrow Cells on the Liver for Purine Supply

1958 • 158 citations

Refractory Megaloblastic Anemia Associated with Excretion of Orotic Acid

1959 • 153 citations

Allopurinol: Alteration in Pyrimidine Metabolism in Man

1970 • 151 citations

Reversible Dissociation of Carbamyl Phosphate Synthetase into a Regulated Synthesis Subunit and a Subunit Required for Glutamine Utilization

1971 • 138 citations

Orotidinuria Induced by Allopurinol

1970 • 128 citations

Studies on the coordinate activity and lability of orotidylate phosphoribosyltransferase and decarboxylase in human erythrocytes, and the effects of allopurinol administration

1971 • 104 citations

Regulation of pyrimidine and arginine biosynthesis in mammals

1971 • 92 citations

Hyperammonaemia: a deficiency of liver ornithine transcarbamylase. Occurrence in mother and child.

1969 • 91 citations

Purification and Kinetic Properties of Brain Orotidine 5′-Phosphate Decarboxylase

1968 • 87 citations

PYRIMIDINE METABOLISM IN MAN. I. THE BIOSYNTHESIS OF OROTIC ACID*†

1959 • 84 citations

Copurification of carbamoyl phosphate synthetase and aspartate transcarbamoylase from mouse spleen

1971 • 80 citations

Variations in purine metabolism of cultured skin fibroblasts from patients with gout

1968 • 74 citations

Purification and Properties of Orotic Acid-decarboxylating Enzymes from Calf Thymus

1964 • 71 citations

Studies on the control of pyrimidine biosynthesis in human diploid cell strains, I. Effect of 6-azauridine on cellular phenotype.

1967 • 69 citations

Regulation of activity of carbamoyl phosphate synthetase from mouse spleen

1971 • 68 citations

THE URICOSURIA AND OROTIC ACIDURIA INDUCED BY 6-AZAURIDINE*

1961 • 68 citations

Initial steps in pyrimidine synthesis in ehrlich ascites carcinoma

1971 • 67 citations

Channeling in Neurospora Metabolism

1967 • 67 citations

Orotic aciduria

1969 • 56 citations

On the availability of intramitochondrial carbamoylphosphate for the extramitochondrial biosynthesis of pyrimidines

1969 • 54 citations

Activation by 5-phosphoribosyl 1-pyrophosphate of glutamine-dependent carbamyl phosphate synthetase from mouse spleen

1972 • 54 citations

STUDIES ON THE ORIGIN OF PYRIMIDINES FOR BIOSYNTHESIS OF NEURAL RNA IN THE RAT

1971 • 52 citations

HYPERAMMONEMIA DUE TO A MUTANT ENZYME OF ORNITHINE TRANSCARBAMYLASE

1971 • 50 citations

Mechanism of allopurinol-mediated inhibition of pyrimidine biosynthesis.

1971 • 50 citations

Mechanism of allopurinol-mediated increase in enzyme activity in man

1972 • 47 citations

PYRIMIDINE METABOLISM IN MAN. III. STUDIES ON LEUKOCYTES AND ERYTHROCYTES IN PERNICIOUS ANEMIA*†

1960 • 33 citations

Regulation of Purine and Pyrimidine Metabolism

1971 • 30 citations

THE METABOLISM OF RING-LABELED OROTIC ACID IN MAN

1962 • 25 citations

Rates of formation of blood-borne uridine and cytidine in dogs

1971 • 21 citations

Hereditary orotic aciduria—Pyrimidine auxotrophism in man

1965 • 18 citations

Deoxyribonucleotide Synthesis and the Role of Vitamin B12 in Erythropoiesis

1969 • 15 citations

Studies on congenital orotic aciduria: comparison of orotic acid metabolism in microorganisms.

1963 • 7 citations

Gene Action in Human Diploid Cell Strains

1969 • 5 citations

Human pyrimidine metabolism

1966 • 3 citations