Antisense inhibition of Engrailed genes in mouse embryos reveals roles for these genes in craniofacial and neural tube development

A formaldehyde - glutaraldehyde fixative of high osmolarity for use in electron microscopy

1965 • 5,954 citations

Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity

1993 • 2,146 citations

The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain

1990 • 1,531 citations

Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development

1990 • 896 citations

Mouse Wnt genes exhibit discrete domains of expression in the early embryonic CNS and limb buds

1993 • 800 citations

Wnt-3a regulates somite and tailbud formation in the mouse embryo.

1994 • 784 citations

Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo

1993 • 680 citations

The midbrain-hindbrain phenotype of Wnt-1−Wnt-1− mice results from stepwise deletion of engrailed-expressing cells by 9.5 days postcoitum

1992 • 579 citations

Expression of the proto-oncogene int-1 is restricted to specific neural cells in the developing mouse embryo

1987 • 578 citations

Multiple developmental defects in Engrailed-1 mutant mice: an early mid-hindbrain deletion and patterning defects in forelimbs and sternum

1994 • 509 citations

The engrailed locus of drosophila: In situ localization of transcripts reveals compartment-specific expression

1985 • 456 citations

Subtle Cerebellar Phenotype in Mice Homozygous for a Targeted Deletion of the En-2 Homeobox

1991 • 416 citations

Expression patterns of the homeo box-containing genes En-1 and En-2 and the proto-oncogene int-1 diverge during mouse development.

1988 • 393 citations

Two-tiered regulation of spatially patterned engrailed gene expression during Drosophila embryogenesis

1988 • 383 citations

Role of segment polarity genes in the definition and maintenance of cell states in the Drosophila embryo

1988 • 381 citations

En-1 and En-2, two mouse genes with sequence homology to the Drosophila engrailed gene: expression during embryogenesis.

1987 • 330 citations

Neurotrophic protein S100 beta stimulates glial cell proliferation.

1991 • 326 citations

Examining pattern formation in mouse, chicken and frog embryos with an En-specific antiserum

1991 • 325 citations

Abnormal embryonic cerebellar development and patterning of postnatal foliation in two mouse Engrailed-2 mutants

1994 • 310 citations

Induction of floor plate differentiation by contact-dependent, homeogenetic signals

1993 • 271 citations

Expression of the homeo box-containing gene En-2 delineates a specific region of the developing mouse brain.

1988 • 225 citations

Culture of early somite mouse embryos during organogenesis

1979 • 151 citations

A gene with sequence similarity to Drosophila engrailed is expressed during the development of the neural tube and vertebrae in the mouse

1988 • 144 citations

Induction and axial patterning of the neural plate: Planar and vertical signals

1993 • 104 citations

Antisense attenuation of Wnt‐1 and Wnt‐3a expression in whole embryo culture reveals roles for these genes in craniofacial, spinal cord, and cardiac morphogenesis

1993 • 90 citations

Expression of engrailed in the parasegment of Drosophila

1985 • 78 citations

Ultrastructure of neural crest formation in the midbrain/rostral hindbrain and preotic hindbrain regions of the mouse embryo

1987 • 47 citations

Improved growth and development of presomite mouse embryos in whole embryo culture

1988 • 31 citations

Regulations in the induction of the organized neural system in amphibian embryos

1990 • 26 citations

Antisense targeting of Engrailed‐1 causes abnormal axis formation in mouse embryos

1995 • 18 citations

Leaked report on Star Wars

1988 • 5 citations