The discriminative stimulus properties of (+)-HA-966, an antagonist at the glycine/N-methyl-D-aspartate receptor

The behavioural effects of MK-801: a comparison with antagonists acting non-competitively and competitively at the NMDA receptor

1989 • 434 citations

MK-801, a proposed noncompetitive antagonist of excitatory amino acid neurotransmission, produces phencyclidine-like behavioral effects in pigeons, rats and rhesus monkeys.

1988 • 302 citations

Glycine reverses antagonism of N-methyl-D-aspartate (NMDA) by 1-hydroxy-3-aminopyrrolidone-2 (HA-966) but not by D-2-amino-5-phophonovalerate (D-AP5) on rat cortical slices

1988 • 162 citations

Enantiomers of HA-966 (3-amino-1-hydroxypyrrolid-2-one) exhibit distinct central nervous system effects: (+)-HA-966 is a selective glycine/N-methyl-D-aspartate receptor antagonist, but (-)-HA-966 is a potent gamma-butyrolactone-like sedative.

1990 • 135 citations

Modulation of seizure susceptibility in the mouse by the strychnine‐insensitive glycine recognition site of the NMDA receptor/ion channel complex

1990 • 109 citations

Is the discriminative stimulus produced by phencyclidine due to an interaction with N-methyl-d-aspartate receptors?

1988 • 78 citations

A role for receptors of N-methyl-D-aspartic acid in the discriminative stimulus properties of phencyclidine

1987 • 71 citations

The discriminative stimulus effects of N-methyl-d-aspartate antagonists in phencyclidine-trained rats

1988 • 56 citations

Protection Against N‐methyl‐D‐aspartate Receptor‐Mediated Neuronal Degeneration In Rat Brain by 7‐chlorokynurenate and 3‐amino‐1‐hydroxypyrrolid‐2‐one, Antagonists at The Allosteric Site for Glycine

1990 • 50 citations

Resolution and synthesis of the individual enantiomers of the glycine antagonist 3-amino-1-hydroxypyrrolidin-2-one (HA-966)

1989 • 13 citations