TPA‐induced activation of MAP kinase

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

1991 • 1,901 citations

Identification of phosphotyrosine as a product of epidermal growth factor-activated protein kinase in A-431 cell membranes.

1980 • 1,184 citations

Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase

1990 • 1,087 citations

An Insulin-Stimulated Protein Kinase Similar to Yeast Kinases Involved in Cell Cycle Control

1990 • 701 citations

Rapid stimulation by insulin of a serine/threonine kinase in 3T3-L1 adipocytes that phosphorylates microtubule-associated protein 2 in vitro.

1987 • 604 citations

The phorbol ester receptor: a phospholipid-regulated protein kinase

1985 • 522 citations

Substrate specificity of protein kinase C

1986 • 521 citations

The periodic association of MAP2 with brain microtubules in vitro.

1979 • 510 citations

Multiple components in an epidermal growth factor-stimulated protein kinase cascade

1991 • 502 citations

Evidence that pp42, a major tyrosine kinase target protein, is a mitogen-activated serine/threonine protein kinase.

1989 • 442 citations

Insulin-stimulated microtubule-associated protein kinase is phosphorylated on tyrosine and threonine in vivo.

1988 • 404 citations

Identification of multiple epidermal growth factor-stimulated protein serine/threonine kinases from Swiss 3T3 cells.

1990 • 336 citations

Protein kinase C — a family affair

1989 • 289 citations

Activation of a Ca2+-inhibitable protein kinase that phosphorylates microtubule-associated protein 2 in vitro by growth factors, phorbol esters, and serum in quiescent cultured human fibroblasts.

1988 • 240 citations

Separation and characterization of microtubule proteins from calf brain

1977 • 203 citations

Okadaic acid mimics the action of insulin in stimulating protein kinase activity in isolated adipocytes. The role of protein phosphatase 2a in attenuation of the signal.

1990 • 183 citations

Purification and properties of extracellular regulated kinase 1, an insulin-stimulated microtubule-associated protein 2 kinase

1991 • 175 citations

A 42-kD tyrosine kinase substrate linked to chromaffin cell secretion exhibits an associated MAP kinase activity and is highly related to a 42-kD mitogen-stimulated protein in fibroblasts.

1990 • 142 citations

Purification and characterization of a maturation-activated myelin basic protein kinase from sea star oocytes.

1990 • 141 citations

Diverse mitogenic agents induce rapid phosphorylation of a common set of cellular proteins at tyrosine in quiescent mammalian cells.

1985 • 125 citations

Defective regulation of mitogen-activated protein kinase activity in a 3T3 cell variant mitogenically nonresponsive to tetradecanoyl phorbol acetate.

1991 • 92 citations

The interrelationship between cAMP-dependent alpha and beta subunit phosphorylation in the regulation of phosphorylase kinase activity. Studies using subunit specific phosphatases.

1987 • 81 citations

In vivo activation of a microtubule‐associated protein kinase during meiotic maturation of the Xenopus oocyte

1990 • 69 citations

Identification of a 42-kilodalton phosphotyrosyl protein as a serine(threonine) protein kinase by renaturation.

1990 • 60 citations

Mitogen‐stimulated tyrosine phosphorylation of a 42‐kD cellular protein: Evidence for a protein kinase‐C requirement

1988 • 40 citations