The specificity of inhibition of debrisoquine 4-hydroxylase activity by quinidine and quinine in the rat is the inverse of that in man

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

POLYMORPHIC HYDROXYLATION OF DEBRISOQUINE IN MAN

1977 • 1,196 citations

Characterization of the common genetic defect in humans deficient in debrisoquine metabolism

1988 • 717 citations

Interethnic differences in genetic polymorphism of debrisoquin and mephenytoin hydroxylation between Japanese and Caucasian populations

1985 • 459 citations

Oxidation of quinidine by human liver cytochrome P-450.

1986 • 296 citations

Competitive inhibition of sparteine oxidation in human liver by β-adrenoceptor antagonists and other cardiovascular drugs

1984 • 185 citations

Monooxygenase activity of human liver in microsomal fractions of needle biopsy specimens.

1980 • 152 citations

Animal modelling of human polymorphic drug oxidation—the metabolism of debrisoquine and phenacetin in rat inbred strains

1981 • 141 citations

Debrisoquine 4-Hydroxylase: Characterization of a New P450 Gene Subfamily, Regulation, Chromosomal Mapping, and Molecular Analysis of the DA Rat Polymorphism

1987 • 139 citations

Quinidine and the identification of drugs whose elimination is impaired in subjects classified as poor metabolizers of debrisoquine.

1986 • 94 citations

Biphasic O-deethylation of phenacetin and 7-ethoxycoumarin by human and rat liver microsomal fractions

1981 • 85 citations

Characterization of a human liver cytochrome P-450 involved in the oxidation of debrisoquine and other drugs by using antibodies raised to the analogous rat enzyme.

1984 • 68 citations

Assay and characterisation of debrisoquine 4‐hydroxylase activity of microsomal fractions of human liver.

1982 • 64 citations

Substrate specificity of the form of cytochrome P-450 catalyzing the 4-hydroxylation of debrisoquine in man.

1983 • 62 citations

Sex and strain differences in hepatic debrisoquine 4-hydroxylase activity of the rat.

1985 • 52 citations

Bufuralol 1'-hydroxylase activity of the rat

1986 • 33 citations

Attempts to phenotype human liver samples in vitro for debrisoquine 4‐ hydroxylase activity.

1985 • 9 citations

In vitro studies of induction and inhibition of drug oxidation in man

1987 • 8 citations